Products from SYNkinase
SYNkinase, headquartered in Australia, is a primary producer of research-use-only biomedical reagents, which it markets to life-science and drug-discovery researchers affiliated with universities, research institutes and industry. SYNkinase was established in 2008 by Professor Andrew Wilks and Dr. Xian Bu. The founders of the company have been involved in pharmaceutical drug discovery for three decades and have extensive scientific, company and board experience.
More information at: www.adipogen.com/synkinase
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XL-019
Item number: SYN-1191-M001
Soluble in DMSO. XL019 is a potent JAK2 inhibitor (IC(50) of 2nM) with excellent selectivity versus the other members of the JAK kinase family (JAK1, IC(50) of 130nM, JAK3, IC(50) of 250nM, TYK2, IC(50) of 340nM).
| Keywords: | XL-019 |
| Application: | JAK2 inhibitor |
| CAS | 945750-13-0 |
| MW: | 444,5 D |
From 250.00€
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KW-2449
Item number: SYN-1205-M001
Soluble in DMSO or ethanol. KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 with IC(50) of 6.6nM, modestly potent to FGFR1, Bcr-Abl and Aurora A, little effect on PDGFRbeta, IGF-1R, EGFR.
| Keywords: | KW2449 |
| Application: | FLT3 inhibitor |
| CAS | 841259-17-4 |
| MW: | 368,9 D |
From 66.00€
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BBT594
Item number: SYN-1225-M001
BBT594 (NVP-BBT594) is a potent and selective inhibitor of RET and JAK2. BBT594 impairs "glial-derived neurotrophic factor" (GDNF)-RET signaling and GDNF-dependent growth in specific in vitro models. Direct inhibition of GDNF-RET signaling by BBT594 in ER+ breast cancer cells enhances the sensitivity to aromatase...
| Keywords: | BBT-594 |
| Application: | Potent, selective RET / JAK2 inhibitor |
| CAS | 882405-89-2 |
| MW: | 569.6 D |
From 250.00€
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Alpelisib
Item number: SYN-1230-M001
Solid. Soluble in DMSO or DMF. Selective PI3Kalpha inhibitor with IC50 of 5nM. Has minimal effect on other PI3K isoforms. Exhibits favorable pharmacokinetics and excellent oral bioavailability in animal models. In xenografts using nude mice, it showed dose-dependent effects of tumour inhibition. In a phase Ib study,...
| Keywords: | (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide, BYL719,... |
| Application: | Selective PI3K alpha inhibitor |
| CAS | 1217486-61-7 |
| MW: | 441,5 D |
From 106.00€
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Selonsertib
Item number: SYN-1231-M001
Solid. Soluble in DMSO. Insoluble in water. Selonsertib, also known as GS-4997, is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. GS-4997 targets and binds to the catalytic kinase domain of ASK1 in an...
| Keywords: | GS-4997 (free base),... |
| Application: | ASK1 inhibitor |
| CAS | 1448428-04-3 |
| MW: | 445,5 D |
From 119.00€
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I-BET762
Item number: SYN-3033-M001
I-BET762 (GSK525762A) is an inhibitor for BET (bromodomain and extra terminal domain) proteins, BRD2, BRD3 and BRD4. It binds to the tandem bromodomains of BET with a Kd of 50.5-61.3nM, displaces a tetra-acetylated H4 peptide prebound to tandem bromodomains of BET with IC50 of 32.5-42.5nM in FRET analysis. I-BET762...
| Keywords: | GSK-525762A |
| Application: | BET (bromodomain and extra terminal domain) protein BRD2 / BRD3 / BRD4 inhibitor |
| CAS | 1260907-17-2 |
| MW: | 423.9 D |
From 106.00€
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MPI_5a
Item number: SYN-3040-M001
Solid. Soluble in DMSO. MPI_5a is a potent selective inhibitor of HDAC6. HDAC6 is a predominantly cytoplasmic enzyme that targets alpha-tubulin, cortactin and heat shock protein 90, and other substrates. MPI-5a has an IC50 of 36nM in tumour cell models and inhibits the acetylation of tubulin in cells with an IC50...
| Keywords: | MPI5a, N-Hydroxy-2-(1-methyl-1H-pyrrole-2-carbonyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide |
| Application: | HDAC6 inhibitor |
| CAS | 1259296-46-2 |
| MW: | 299,3 D |
From 106.00€
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EPZ015666
Item number: SYN-3044-M001
Off-white solid. Soluble in 100% ethanol (1 mg/ml) or DMSO (10 mg/ml), insoluble in water. Dynamin-1, -2 (DNM1, DNM2) and Dynamin-related protein 1 (DRP1) inhibitor, Endocytosis inhibitor, Viral infection inhibitor, Destabilizes actin filaments, Inhibits entry of Trypanosoma into macrophages, Inhibitor of mitophagy,...
| Keywords: | 3-Hydroxy-naphthalene-2-carboxylic acid (3,4-dihydroxy-benzyl-idene)-hydrazide . 0.5H2O |
| CAS | 1616391-65-1 |
From 106.00€
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AZ9482
Item number: SYN-3046-M001
AZ9482 is a potent and selective PARP inhibitor featuring an amide linkage to a 2-piperazinyl-3-cyano-pyridine. AZ9482 exhibits very potent centrosome declustering activity in HeLa cells (EC50 < 18nM). AZ9482 also showed a 3nM GI50 in the DLBCL cell line OCI-LY-19 in a 3-day AlamarBlue assay. Consistent with...
| Keywords: | 2-(4-(3-((4-Oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazin-1-yl)nicotinonitrile |
| Application: | Potent, selective PARP inhibitor |
| CAS | 1825345-33-2 |
| MW: | 450.5 D |
From 119.00€
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Akt-I-1
Item number: SYN-1005-M001
Soluble in DMSO. The compound (Akt-I-1) inhibits only Akt1 (IC(50) 4.6 µM) and does not inhibit AKT2, or AKT3. The compound is a reversible inhibitor, and exhibits a linear mixed-type inhibition against ATP and peptide substrate. In addition to inhibiting kinase activity of AKT1 isoform, AKT-I-1 blocked the...
| Keywords: | AktI1 |
| Application: | Akt1 inhibitor |
| CAS | 473382-39-7 |
| MW: | 378,5 D |
From 256.00€
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BI-D1870
Item number: SYN-1020-M001
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. BI-D1870 is a small molecule, specific inhibitor of p90 RSK (ribosomal S6 kinase) isoforms RSK1, RSK2, RSK3 and RSK4, both in vitro and in vivo, with IC(50)s are 31nM, 24nM, 18nM, 15nM, respectively. It shows a 10- to 100-fold selectivity for RSK over MST2,...
| Keywords: | BID1870 |
| Application: | RPS6KA inhibitor |
| CAS | 501437-28-1 |
| MW: | 391,4 D |
From 119.00€
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CYC116
Item number: SYN-1034-M001
Soluble in DMSO or ethanol. CYC116 is an orally active small molecule multi-kinase inhibitor with anti-neoplastic activity. CYC116 inhibits Aurora kinases A/B and vascular endothelial growth factor receptor 2 (VEGFR2), resulting in disruption of the cell cycle, rapid cell death, and the inhibition of angiogenesis....
| Keywords: | CYC-116 |
| Application: | Aurora A / B inhibitor |
| CAS | 693228-63-6 |
| MW: | 368,5 D |
From 79.00€
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