Virginiamycin S1 is a macrolide antibiotic that is a component of the virginiamycin complex (Cay-14503), which also contains virginiamycin M1 (Cay-9002172). It is a member of the streptogramin B group of antibiotics, which bind the 50S ribosomal subunit at the peptidyl transferase center to inhibit initiation and...

Virginiamycin M1 is a macrolide antibiotic. It is a member of the streptogramin A group of antibiotics, which bind the 50S ribosomal subunit at the peptidyl transferase center to inhibit initiation and translocation. They show good bactericidal activity against methicillin-resistant S. aureus (MRSA), although...

Virginiamycin complex contains two streptogramin antibiotics, virginiamycin M1 (75%, Cay-9002172) and virginiamycin S1 (25%, Cay-17455), produced by S. virginiae. As a complex, the two antibiotics act synergistically to irreversibly inhibit protein synthesis in bacteria. When given to livestock, virginiamycin...

Dalfopristin is a streptogramin antibiotic that blocks peptide bond formation and peptide extension in bacteria. Dalfopristin is usually combined with another streptogramin antibiotic, quinupristin (Cay-19764), to produce Quinupristin-Dalfopristin Complex, known commercially as Synercid. While both quinupristin and...

Quinupristin is a streptogramin antibiotic that blocks peptide bond formation and peptide extension in bacteria. Quinupristin is usually combined with another streptogramin antibiotic, dalfopristin (Cay-19762), to produce quinupristin-dalfopristin complex, known commercially as Synercid. While both quinupristin and...

Streptogramin B is a macrolide antibiotic. It inhibits the growth of Clostridium, Peptostreptococcus, and Propionibacterium bacterial species (MIC90s = 2, 0.5, and 8 µg/ml, respectively). Streptogramin B inhibits protein synthesis by interacting with the 50S ribosome. Resistance to streptogramin B is conferred by...