86 products were found matching "maxspec"!

Many lipids have a free carboxylic acid group that typically requires a weak acid mobile phase to ensure retention by HPLC. Unfortunately, the presence of the acid in the mobile phase also suppresses anion formation and often leads to poor electrospray ionization and poor MS sensitivity. Cayman's AMP+ MaxSpec(R) Kit...

Arachidonic acid is an essential fatty acid and a precursor for all prostaglandins, thromboxanes, and leukotrienes. Virtually all cellular arachidonic acid is esterified in membrane phospholipids where its presence is tightly regulated through multiple interconnected pathways. Free arachidonic acid is a transient,...

Prostaglandin E2 (PGE2) is one of the primary COX products of arachidonic acid (Cay-90010) and one of the most widely investigated PGs. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation. The effects of PGE2 are transduced by at least four distinct...

This mixture contains several D-series resolvins (specialized pro-resolving mediators, SPMs) and their precursor, docosahexaenoic acid (DHA, Cay-90310). The mixture is supplied in an amber ampule in which the headspace has been purged with argon to prevent lipid oxidation. This product has been designed for direct...

The EPA CYP450 oxylipin MaxSpec(R) LC-MS mixture contains various regioisomers of epoxides and dihydroxy fatty acids derived from the sequentional metabolism of eicosapentaenoic acid (EPA, Cay-90110, Cay-21908) via CYP450 and soluble epoxide hydrolase. The mixture is supplied in an amber ampule in which the...

This mixture contains several lipoxins and their precursor, arachidonic acid (Cay-90010). The mixture is supplied in an amber ampule in which the headspace has been purged with argon to prevent lipid oxidation. This product has been designed for direct use in LC-MS applications. The solution may be serially diluted...

The linoleic acid oxylipins MaxSpec(R) LC-MS Mixture contains oxylipin metabolites derived from linoleic acid (Cay-90150). The mixture is supplied in an amber ampule in which the headspace has been purged with argon to prevent lipid oxidation. This product has been designed for direct use in LC-MS applications. The...

Prostaglandin E2-d4 (PGE2-d4) is intended for use as an internal standard for the quantification of PGE2 (Cay-14010) by GC- or LC-MS. PGE2 is one of the primary cyclooxygenase products of arachidonic acid (Cay-90010) and one of the most widely investigated prostaglandins. Its activity influences inflammation,...

20-HETE is a cytochrome P450 (CYP450) metabolite postulated to play an autacoid role in the renal and cerebral vasculature. In rat cerebral microvessels, 20-HETE is a vasoconstrictor that mediates pressure-induced autoregulatory vasoconstriction. 20-HETE is excreted mainly as the glucuronide conjugate. The...

Bile Acids MaxSpec(R) Discovery Mixture contains a variety of standards for the analysis of bile acids. Bile acids are formed in the liver primarily from cholesterol and then transformed by intestinal microbiota into a diverse array of secondary bile acids. Primary and secondary bile acids can be modified by...

This mixture contains selected eicosanoids produced by the metabolism of arachidonic acid via the cyclooxygenase and lipoxygenase pathways. The mixture is supplied in an amber ampule in which the headspace has been purged with argon to prevent lipid oxidation. This product has been designed for direct use in LC-MS...

Prostaglandin D2 (PGD2) is the major eicosanoid product of mast cells and is released in large quantities during allergic and asthmatic anaphylaxis. Mastocytosis patients produce excessive amounts of PGD2, which causes vasodilation, flushing, hypotension, and syncopal episodes. PGD2 is also produced in the brain via...