Protein function: Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli. [The UniProt Consortium]

Anti-HCN1 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with HCN1 from Human, Rat, and Mouse based on 100% homology with the immunizing sequence. No cross-reactivity against HCN2. Cross-reactivity with HCN1 from other sources has not been determined....

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is...