Description: Associates with IFNAR1 to form the plasma membrane receptor in the type I interferon signaling pathway. Directly involved in signal transduction through its association with the TYR kinase JAK1. Involved in interferon-mediated STAT1, STAT2 and STAT3 activation., May be potent inhibitors of type I IFN...

Organism: Mus musculus (Mouse). Source: Yeast. Expression Region: 22-242aa. Protein Length: Extracellular Domain. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: SLETITPSAF DGYPDEPCTI NITIRNSRLI LSWELENKSG PPANYTLWYT VMSKDENLTK VKNCSDTTKS SCDVTDKWLE GMESYVVAIV IVHRGDLTVC RCSDYIVPAN APLEPPEFEI VGFTDHINVT...

Recombinant Biotinylated Mouse IFN alpha/beta R2 Protein is expressed from HEK293 with His tag and Avi tag at the C-terminus.It contains Ser22-Ala242. Although interferon (IFN)-alpha is known to exert immunomodulatory and antiproliferative effects on dendritic cells (DCs) through induction of protein-coding...

Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....

Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 2 and 3 may be potent...