19 products were found matching "K22599"!

Description: Lopinavir (ABT-378) is a peptidomimetic HIV protease inhibitor effective against HIV protease with the Val 82 mutation. It is less affected by serum protein binding compared to the structurally related drug ritonavir. Target: SARS-CoV, HIV Protease. Smiles:...

Description: Ritonavir (ABT 538) is a peptidomimetic agent that inhibits both HIV-1 and HIV-2 proteases. Ritonavir is highly inhibited by serum proteins but boosts the effect of other HIV proteases by blocking their degradation by cytochrome P450. Target: SARS-CoV, Apoptosis, HIV Protease. Smiles:...

Description: Brecanavir is a tyrosyl-based arylsulfonamide, high affinity, protease inhibitor (PI) for the treatment of human immunodeficiency virus type 1. Target: Others. Smiles: O(C(N[C@@H](CC1=CC=C(OCC=2N=C(C)SC2)C=C1)[C@@H](CN(S(=O)(=O)C=3C=C4C(=CC3)OCO4)CC(C)C)O)=O)[C@@H]5[C@]6([C@@](OC5)(OCC6)[H])[H]....

Description: Palinavir is an antiviral, it inhibits HIV-1 protease. Target: Others. Smiles: C([C@H]([C@H](CC1=CC=CC=C1)NC([C@@H](NC(=O)C2=NC3=C(C=C2)C=CC=C3)[C@H](C)C)=O)O)N4[C@H](C(NC(C)(C)C)=O)C[C@H](OCC=5C=CN=CC5)CC4. References: Lamarre D, Croteau G, Wardrop E, Bourgon L, Thibeault D, Clouette C, Vaillancourt M,...

Description: Nelfinavir (AG1341) is an antiretroviral drug used in the treatment of the human immunodeficiency virus (HIV) (Ki=2 nM). Nelfinavir is a broad-spectrum, anticancer agent. Target: HIV Protease. Smiles: Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C. References:...

Ritonavir is an HIV protease inhibitor. It inhibits recombinant HIV-1 protease by 79% when used at a concentration of 0.5 nM. It inhibits HIV-13B-induced cell death in MT-4 human T cell leukemia cells (EC50 = 25 nM) as well as cell death induced by HIV-1LAI, HIV-2ROD, and HIV-2EHO in human MT-2 cells (IC50s = 0.045,...

Saquinavir is an HIV protease inhibitor (Kis = 0.12 and 50 = 2 nM). It also inhibits the activity of the severe acute respiratory coronavirus 2 (SARS-CoV-2) main protease (Mpro), also known as 3C-like protease (3CLpro), with an IC50 value of 9.92 µM.Formal Name:...

Tipranavir is a potent, orally bioavailable nonpeptidic HIV aspartyl protease inhibitor (Ki = 95%. Formulation: (Request formulation change), A crystalline solid. Solubility: Chloroform: slightly soluble, Methanol: slightly soluble. lambdamax: 254 nm. SMILES:...

Soluble in DMSO (15mg/ml), DMF (20mg/ml) or ethanol (20mg/ml). Nelfinavir is an orally bioavailable competitive inhibitor of the human immunodeficiency virus. It potently inhibits HIV-1 (Ki=2nM) and HIV-2 protease in vitro. HIV-1 protease is important for the replication of the virus within the cell and the release...

Soluble in DMSO (10mg/ml). Saquinavir is an antiretroviral inhibitor of the human immunodeficiency virus. It potently inhibits HIV-1 (Ki=0.12nM) and HIV-2 (Ki<0.1nM) protease in vitro. HIV-1 protease is important for the replication of the virus within the cell and the release of mature viral particles from the...

Fosamprenavir is a prodrug form of the HIV-1 protease inhibitor amprenavir (Cay-15369). It is converted to amprenavir by alkaline phosphatase in the intestinal epithelium. Formulations containing fosamprenavir have been used in the treatment of HIV infections.Formal Name:...

Saquinavir-d9 is intended for use as an internal standard for the quantification of saquinavir (Cay-9001893) by GC- or LC-MS. Saquinavir is an HIV protease inhibitor (Kis = 0.12 and 50 = 2 nM). It also inhibits the activity of the severe acute respiratory coronavirus 2 (SARS-CoV-2) main protease (Mpro), also known...