28 products were found matching "K22038"!
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Endovion
Item number: TGM-T15233-100mg
Description: Endovion (NS3728) is a pharmacological anion channel and an Anoctamin-1 (ANO 1) channel inhibitor. Endovion is also the specific VRAC/VSOAC blocker. Target: Chloride channel. Smiles: FC(F)(F)c1cc(NC(=O)Nc2ccc(Br)cc2-c2nn[nH]n2)cc(c1)C(F)(F)F. References: Sørensen BH, et al. Downregulation of LRRC8A...
| Keywords: | NS3728 |
| Application: | Chloride channel inhibitor |
| CAS | 265646-85-3 |
| MW: | 495.18 D |
From 31.00€
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NS3623
Item number: TGM-T16347-100mg
Description: NS3623 is an activator of human ether-a-go-go-related gene (hERG) potassium channels with a dual mode of action, also acting as an inhibitor of hERG1 channels. It activates the IKr and Ito currents and exhibits an antiarrhythmic effect. Target: Potassium Channel. Smiles:...
| Application: | Ion channel modulator, VRAC inhibitor |
| CAS | 343630-41-1 |
| MW: | 427.18 D |
From 34.00€
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NS 3728
Item number: Cay39988-10
NS 3728 is a chloride channel inhibitor. It inhibits the volume-regulated anion channel (VRAC) in HEK293 cells and chloride conductance in washed isolated human erythrocytes (IC50s = 0.4 and 0.6 µM, respectively). NS 3728 also inhibits calcium-activated chloride currents in Ehrlich-Lettre ascites carcinoma cells...
| Keywords: | Endovion, SCO 101, N-[3,5-bis(trifluoromethyl)phenyl]-N'-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]-urea |
| Application: | Chloride channel inhibitor |
| CAS | 265646-85-3 |
| MW: | 495.2 D |
From 133.00€
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Anti-LRRC8A
Item number: A304-175A
Protein function: Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic...
| Keywords: | Anti-LRRC8A, Anti-KIAA1437, Anti-Swelling protein 1, Anti-Leucine-rich repeat-containing protein 8A, Anti-Volume-regulated... |
| Application: | WB, IP |
| Host: | Rabbit |
| Species reactivity: | human, mouse |
From 164.00€
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DCPIB
Item number: Cay34064-5
DCPIB is an inhibitor of volume-regulated anion channels (VRAC). It inhibits the swelling-induced chloride current (ICl,swell) in bovine pulmonary artery endothelial cells (IC50 = 4.1 µM). DCPIB inhibits the VRAC subunit leucine-rich containing 8A (LRRC8A, IC50 = 20.9 µM) and inhibits sphingosine-1-phosphate-induced...
| Keywords: | 4-[(2-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]-butanoic acid |
| Application: | VRAC inhibitor |
| CAS | 82749-70-0 |
| MW: | 427.4 D |
From 98.00€
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Anti-LRRC8E
Item number: G-PACO36750.50
LRRC8E Antibody is a IgG polyclonal antibody from Assay Genie with reactivity against Human and for use in ELISA, IHC, IF applications. LRRC8E Antibody is a high quality polyclonal antibody for research use only.. Protein function: Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC...
| Keywords: | Anti-LRRC8E, Anti-Leucine-rich repeat-containing protein 8E, Anti-Volume-regulated anion channel subunit LRRC8E |
| Application: | ELISA, IHC, IF |
| Host: | Rabbit |
| Species reactivity: | human |
363.00€
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Anti-LRRC8E
Item number: ATA-HPA020466.100
Protein function: Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26824658, PubMed:28193731). The VRAC channel conducts...
| Keywords: | Anti-LRRC8E, Anti-Leucine-rich repeat-containing protein 8E, Anti-Volume-regulated anion channel subunit LRRC8E |
| Application: | IHC |
| Host: | Rabbit |
| Species reactivity: | human |
From 335.00€
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Anti-LRRC8B
Item number: ATA-HPA017950.100
Protein function: Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26824658, PubMed:28193731). The VRAC channel conducts...
| Keywords: | Anti-LRRC8B, Anti-TA-LRRP, Anti-KIAA0231, Anti-Leucine-rich repeat-containing protein 8B, Anti-T-cell activation leucine... |
| Application: | ICC, IHC |
| Host: | Rabbit |
| Species reactivity: | human |
From 335.00€
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NS 3623
Item number: Cay34992-10
NS 3623 is an ion channel modulator. It inhibits the volume-regulated anion channel (VRAC) in HEK293 cells and chloride conductance in isolated human red blood cells (IC50s = 1.8 and 0.21 µM, respectively). NS 3623 also activates human-ether-a-go-go (hERG), also known as Kv11.1 (EC50 = 79.4 µM) but does not activate...
| Keywords: | N-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]-N'-[3-(trifluoromethyl)phenyl]-urea |
| Application: | Ion channel modulator, VRAC inhibitor |
| CAS | 343630-41-1 |
| MW: | 427.2 D |
From 150.00€
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LRRC8B (Vector Vector will be determined during the...
Item number: CSB-CL740748HU.10
Length: 2412 Sequence: atgattacac taactgagct aaaatgctta gcagatgctc agtcatctta tcacatctta aaaccatggt gggacgtctt ctggtattac atcacactga tcatgctgct ggtggccgtg ctggccggag ctctccagct gacgcagagc agggttctgt gctgtcttcc atgcaaagtg gaatttgaca atcactgtgc cgtgccttgg gacatcctga aagccagcat gaacacatcc tctaatcctg ggacaccgct...
| Keywords: | LRRC8B, TA-LRRP, KIAA0231, Leucine-rich repeat-containing protein 8B, Volume-regulated anion channel subunit LRRC8B,... |
| Application: | Molecular biology, clone |
| Species reactivity: | human |
467.00€
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LRRC8E (Vector Vector will be determined during the...
Item number: CSB-CL743982HU.10
Length: 1335 Sequence: atgggggaca ttcctgacgt caagaatgac ttcgccttca tgctgcacct catcgatcag tacgactccc tctactccaa gcgcttcgcc gtcttcctgt ccgaggtcag cgaaagccgt ctaaagcagc tcaatctcaa ccacgagtgg acgcccgaga agcttcgaca gaagctgcag cgcaatgccg cgggccggct ggagctggcc ctctgcatgc tgccgggtct gcccgacacc gtctttgagc tcagtgaggt...
| Keywords: | LRRC8E, Leucine-rich repeat-containing protein 8E, Volume-regulated anion channel subunit LRRC8E |
| Application: | Molecular biology, clone |
| Species reactivity: | human |
171.00€
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LRRC8D (Vector pUC, Accession No. BC024159)
Item number: CSB-CL748719HU2.10
Length: 2577 Sequence: atgtttaccc ttgcggaagt tgcatcactt aatgacattc agccaactta ccgaatcctg aaaccatggt gggatgtgtt tatggattac ctagctgttg ttatgttaat ggtagccatc tttgcaggaa ccatgcaact taccaaagat caggtggtct gtttgccagt attgccatct cctgtaaatt caaaggcaca tacaccacca ggaaatgccg aggtcaccac caacatccca aagatggaag cagccaccaa...
| Keywords: | LRRC5, LRRC8D, Leucine-rich repeat-containing protein 5, Leucine-rich repeat-containing protein 8D, Volume-regulated anion... |
| Application: | Molecular biology, clone |
| Species reactivity: | human |
906.00€
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