23 products were found matching "K20735"!
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Veliflapon
Item number: TGM-T13295-100mg
Description: Veliflapon is an orally active and selective inhibitor of 5-lipoxygenase activating protein (FLAP). Veliflapon inhibits the synthesis of the leukotrienes B4 and C4. Target: LTR. Smiles: [C@H](C(O)=O)(C1=CC=C(OCC2=NC3=C(C=C2)C=CC=C3)C=C1)[C@H]4CCCC4. References: Hatzelmann A, et al. Mode of action of the...
| Keywords: | BAY X 1005, DG-031 |
| Application: | Targets arachidonate 5-lipoxygenase-activating protein (ALOX5AP, FLAP) |
| CAS | 128253-31-6 |
| MW: | 361.43 D |
From 750.00€
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Quiflapon
Item number: TGM-T16087-100mg
Description: Quiflapon (MK-591) causes cell apoptosis. Quiflapon is a selective and specific 5-lipoxygenase-activating protein (FLAP) inhibitor (IC50: 1.6 nM in a FLAP binding assay) and is also an effective and orally active Leukotriene biosynthesis (LT) inhibitor (IC50: 3.1 and 6.1 nM in intact human and elicited...
| Keywords: | MK-591 |
| Application: | FLAP inhibitor |
| CAS | 136668-42-3 |
| MW: | 587.17 D |
From 40.00€
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MK-886
Item number: TGM-T6893-100mg
Description: MK-886 (L 663536) is an inhibitor of leukotriene biosynthesis, acting by inhibiting the 5-lipoxygenase-activating protein (FLAP), and serves as a moderately potent PPARalpha antagonist. Target: Apoptosis, COX, Leukotriene Receptor, FLAP, PPAR. Smiles:...
| Keywords: | L 663536, MK886 |
| Application: | FLAP inhibitor |
| CAS | 118414-82-7 |
| MW: | 472.08 D |
From 31.00€
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Diflapolin
Item number: TGM-T8844-100mg
Description: Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP) and soluble epoxide hydrolase (sEH) inhibitor, exhibiting marked anti-inflammatory efficacy and high target selectivity. Target: Others, Epoxide Hydrolase, FLAP. Smiles: Cc1cc(OCc2nc3ccccc3s2)ccc1NC(=O)Nc1ccc(Cl)c(Cl)c1....
| Application: | 5-lipoxygenase-activating protein (FLAP) inhibitor, soluble epoxide hydrolase (sEH) inhibitor |
| CAS | 724453-98-9 |
| MW: | 458.36 D |
From 38.00€
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Quiflapon sodium
Item number: TGM-TQ0098-100mg
Description: Quiflapon sodium (MK591) is a selective inhibitor of 5-Lipoxygenase-activating protein (FLAP). Target: FLAP. Smiles: [Na].CC(C)(C)Sc1c(CC(C)(C)C(O)=O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3ccc4ccccc4n3)cc12. References: Mendis C, et al. Effect of 5-lipoxygenase inhibitor MK591 on early molecular and signaling events...
| Keywords: | MK591 |
| Application: | Targets arachidonate 5-lipoxygenase-activating protein (ALOX5AP, FLAP) |
| CAS | 147030-01-1 |
| MW: | 610.16 D |
From 83.00€
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Arachidonate 5-lipoxygenase-activating protein (ALOX5AP),...
Item number: CSB-CF001625HU.100
Organism: Homo sapiens (Human). Source: in vitro E.coli expression system. Expression Region: 1-161aa. Protein Length: Full Length. Tag Info: N-terminal 6xHis-SUMO-tagged. Target Protein Sequence: MDQETVGNVV LLAIVTLISV VQNGFFAHKV EHESRTQNGR SFQRTGTLAF ERVYTANQNC VDAYPTFLAV LWSAGLLCSQ VPAAFAGLMY LFVRQKYFVG YLGERTQSTP...
| Keywords: | FLAP, ALOX5AP, MK-886-binding protein, Arachidonate 5-lipoxygenase-activating protein, Recombinant Human Arachidonate... |
| Application: | Activity not tested |
| Expressed in: | E.coli in vitro |
| Origin: | human |
| MW: | 34.2 kD |
From 1,413.00€
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MK-886
Item number: Cay21753-10
MK-886 is a potent, selective inhibitor of 5-lipoxygenase-activating protein (FLAP) that prevents 5-lipoxygenase activation in vivo and inhibits leukotriene biosynthesis in leukocytes with an IC50 of 2.5 nM. In human whole blood, leukotriene biosynthesis is inhibited by MK-886 with an IC50 of 1.1 µM.Formal Name:...
| Keywords: | L-663,536,... |
| Application: | FLAP inhibitor |
| CAS | 118414-82-7 |
| MW: | 472.1 D |
From 46.00€
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Diflapolin
Item number: Cay28103-5
Diflapolin is a dual inhibitor of 5-lipoxygenase-activating protein (FLAP) and soluble epoxide hydrolase (sEH). It inhibits formation of the 5-lipoxygenase (5-LO) products leukotriene B4 (LTB4, Cay-20110) and 5-HpETE (Cay-44230) in isolated human monocytes and neutrophils (IC50s = 30 and 170 nM, respectively) and...
| Keywords: | N-[4-(2-benzothiazolylmethoxy)-2-methylphenyl]-N'-(3,4-dichlorophenyl)-urea |
| Application: | 5-lipoxygenase-activating protein (FLAP) inhibitor, Soluble epoxide hydrolase (sEH) inhibitor |
| CAS | 724453-98-9 |
| MW: | 458.4 D |
From 64.00€
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-30 %
Discount Promotion
Anti-FLAP / ALOX5AP, C-terminal
Item number: ARG63583.100
Protein function: Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes. [The UniProt Consortium]
| Keywords: | Anti-FLAP, Anti-ALOX5AP, Anti-MK-886-binding protein, Anti-Arachidonate 5-lipoxygenase-activating protein |
| Application: | ELISA, WB |
| Host: | Goat |
| Species reactivity: | human |
784.00€
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548.80€
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-30 %
Discount Promotion
Anti-FLAP / ALOX5AP, Internal
Item number: ARG64056.100
Protein function: Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes. [The UniProt Consortium]
| Keywords: | Anti-FLAP, Anti-ALOX5AP, Anti-MK-886-binding protein, Anti-Arachidonate 5-lipoxygenase-activating protein |
| Application: | ELISA, IHC (paraffin), WB |
| Host: | Goat |
| Species reactivity: | human |
784.00€
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548.80€
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Anti-FLAP
Item number: NSJ-R34221-100UG
0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Five-lipoxygenase activating protein, ALOX5AP Protein function: Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could...
| Keywords: | Anti-FLAP, Anti-ALOX5AP, Anti-MK-886-binding protein, Anti-Arachidonate 5-lipoxygenase-activating protein, FLAP Antibody |
| Application: | WB, IHC, ELISA (peptide) |
| Host: | Goat |
| Species reactivity: | human |
755.00€
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GSK2190915
Item number: Cay28600-1
GSK2190915 is a selective inhibitor of human 5-lipoxygenase-activating protein (FLAP, IC50 = 2.9 nM). It is selective for FLAP over 5-, 12-, and 15-lipoxygenase, leukotriene A4 (LTA4) hydrolase, LTC4 synthase, COX-1, and COX-2 (IC50s = >10 µm for all). GSK2190915 inhibits production of LTB4 induced by the calcium...
| Keywords: | AM803,... |
| Application: | FLAP (Arachidonate 5-lipoxygenase-activating protein) inhibitor |
| CAS | 936350-00-4 |
| MW: | 637.8 D |
147.00€
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