32 products were found matching "K19021"!

Protein function: Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. [The UniProt Consortium]

Description: 3,4-Dehydro Cilostazol (OPC-13015), an active metabolite of Cilostazol, is used for pharmacokinetic studies[1]. Target: Others. Smiles: O=c1ccc2cc(OCCCCc3nnnn3C3CCCCC3)ccc2[nH]1. References: T R S Satheeshmanikandan, et al. Liquid Chromatography - Tandem Mass Spectrometry for the Simultaneous...

Protein function: Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. [The UniProt Consortium]

Active human PDE3B (GenBank Accession No. NM_000922), (amino acids 592-end), with N-terminal GST tag, MW = 86 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

Human PDE3A (GenBank Accession No. NM_000921), amino acids 669-1141(end), with N-terminal His-GST tag, MW = 82 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

Vesnarinone is an inhibitor of phosphodiesterase 3 (PDE3, IC50s = 10.7 and 13.2 µM for PDE3A and PDE3B, respectively). It also inhibits ether-a-go-go-related gene 1 (ERG1) channels (IC50 = 1.1 µM in HEK293T cells expressing human ERG1). Vesnarinone (3-300 µM) increases contractile tension in isolated ventricular...

Carbazeran is an inhibitor of phosphodiesterase 2 (PDE2) and PDE3. It inhibits cAMP hydrolysis (IC50 = 4.1 µM in rabbit heart ventricles) selectively over cGMP hydrolysis (IC50 = 171 µM). It induces positive inotropic (EC50 = 100 µM) and negative chronotropic effects in isolated rabbit papillary muscle and right...

Protein function: Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. [The UniProt Consortium]

Mouse PDE3A (GenBank Accession No. NM_018779), amino acids 484-1141 end), with N-terminal GST tag, MW = 100 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

The PDE3B Assay Kit is designed for identification of PDE3B inhibitors using fluorescence polarization. The assay is based on the binding of a fluorescent nucleotide monophosphate generated by PDE3B to the binding agent. The key to the PDE3B Assay Kit is the specific binding agent. Using this kit, only two simple...

Amrinone is an inhibitor of phosphodiesterase 3 (PDE3, IC50 = 19.5 µM). It increases developed tension and contractile force in isolated cat papillary muscle. Amrinone (1-10 mg/kg) has positive inotropic effects, increasing the rate and force of heart contraction in anesthetized and unanesthetized dogs.Formal Name:...

Phosphodiesterases (PDEs) play an important role in the dynamic regulation of cAMP and cAMP signaling. Mouse PDE3A, also known as cAMP-inhibited phosphodiesterase, has been implicated in cardiovascular function and fertility. The Mouse PDE3A1 Assay Kit is designed for identification of inhibitors of Mouse PDE3A1...