41 products were found matching "K18438"!

Description: Balipodect (TAK063) is a highly effective and selective PDE10A inhibitor (IC50: 0.30 nM), Its selectivity is >15000-fold over other PDEs. Target: PDE. Smiles: COc1cn(nc(-c2ccnn2-c2ccccc2)c1=O)-c1ccc(cc1F)-n1cccn1. References: Kunitomo J, et al. J Med Chem. 2014, 57(22):9627-43.

Description: Mardepodect (PF-2545920) is a phosphodiesterase inhibitor selective for the PDE10A subtype with an IC50 of 0.37 nM and over 1000-fold selectivity over PDE. It is potentially useful for the treatment of schizophrenia. Phosphodiesterase 10A (PDE10A) is highly expressed in striatal medium spiny neurons of...

Description: Ligustrazine (Tetramethylpyrazine), a natural compound isolated from Chinese herbal medicine Ligusticum wallichii (Chuan Xiong) shows anti-inflammation, antioxidant, antiplatelet, and antiapoptosis activities. Target: Antioxidant, Apoptosis. Smiles: CC1=NC(C)=C(C)N=C1C. References: Guan D, et al. J...

Description: Ligustrazine hydrochloride (Chuanxiongzine hydrochloride) is a chemical compound found in natto and in fermented cocoa beans with anti-inflammation, antioxidant, antiplatelet, and antiapoptosis activities. Target: Others. Smiles: C.Cc1nc(C)c(C)nc1C. References: Gao HJ, et al. Neural Regen Res. 2015...

Description: SEP-0372814 is a potent inhibitor of PDE10. Target: PDE. Smiles: Cc1c(nc2c3cccnc3ccn12)[C@@H]1C[C@H]1c1nc2c(C)ncc(C)n2n1

Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...

Human PDE10A1 (GenBank Accession No. NM_001130690), a.a. 2-789(end) with N-terminal GST-tag, MW=116 kDa, expressed in Sf9 cells via a Baculovirus expression system. One unit is defined as the amount of enzyme that will convert 1 pmole of 3',5'-cAMP to 5'- AMP per min at 37°C. Assay condition: 10 mM Tris-HCl, pH 7.4,...

The PDE10A Assay Kit is designed for identification of PDE10A inhibitors using fluorescence polarization. The assay is based on the binding of a fluorescent nucleotide monophosphate generated by PDE10A to the binding agent. PDE10A is a dual substrate PDE highly expressed in striatal medium spiny neurons. PDE10A...

Active human PDE10A2 (GenBank Accession No. NM_006661), full length with N-terminal GST tag, MW= 116 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

Papaverine (Cay-10011133) is an analytical reference standard categorized as a muscle relaxant. Papaverine has been found as an impurity in seized heroin. This product is intended for research and forensic applications.Formal Name: 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy isoquinoline. CAS Number: 58-74-2....

TAK-063 is a potent inhibitor of phosphodiesterase 10A (PDE10A, IC50 = 0.3 nM). It is >15,000-fold selective for PDE10A over other PDEs and exhibits 14276, Cay-ISO60194) with a minimum effective dose (MED) of 0.3 mg/kg, p.o., in wild-type mice but has no effect in PDE10A knockout mice at doses up to 1 mg/kg. TAK-063...

White powder. Soluble in DMSO, ethanol or dimethylformamide. Alkaloid antispasmodic drug that most usually treats visceral spasm or vasospasm. It has also been used in the treatment of erectile dysfunction. Smooth muscle relaxant and vasodilator. Phosphodiesterase PDE10A inhibitor. Show to have antiviral and...