42 products were found matching "K18438"!

Description: Balipodect (TAK063) is a highly effective and selective PDE10A inhibitor (IC50: 0.30 nM), Its selectivity is >15000-fold over other PDEs. Target: PDE. Smiles: COc1cn(nc(-c2ccnn2-c2ccccc2)c1=O)-c1ccc(cc1F)-n1cccn1. References: Kunitomo J, et al. J Med Chem. 2014, 57(22):9627-43.

Description: PQ-10 (A-844337) is a PDE-10 inhibitor. PQ-10 induces brain glucose metabolism patterns, which may be a potential translational biomarker. Target: PDE. Smiles: COc1cc2ncnc(N3CCC(C3)Oc3cnc4ccccc4n3)c2cc1OC. References: Attia HN, Maklad YA. Neuroprotective effects of coenzyme Q10 on paraquat-induced...

Description: Ligustrazine (Tetramethylpyrazine), a natural compound isolated from Chinese herbal medicine Ligusticum wallichii (Chuan Xiong) shows anti-inflammation, antioxidant, antiplatelet, and antiapoptosis activities. Target: Antioxidant, Apoptosis. Smiles: CC1=NC(C)=C(C)N=C1C. References: Guan D, et al. J...

Description: Ligustrazine hydrochloride (Chuanxiongzine hydrochloride) is a chemical compound found in natto and in fermented cocoa beans with anti-inflammation, antioxidant, antiplatelet, and antiapoptosis activities. Target: Others. Smiles: C.Cc1nc(C)c(C)nc1C. References: Gao HJ, et al. Neural Regen Res. 2015...

Description: THPP-1 is a potent and orally bioavailable inhibitor of PDE10A(Ki of 1 nM and 1.3 nM for human and rat PDE10A, respectively). Target: PDE. Smiles: COCCOc1nc(nc2CCN(Cc12)C(=O)c1ncn2ccccc12)-c1ccc(Cl)nc1. References: Vardigan JD, et al. Behavioral and qEEG effects of the PDE10A inhibitor THPP-1 in a novel...

Description: SEP-0372814 is a potent inhibitor of PDE10. Target: PDE. Smiles: Cc1c(nc2c3cccnc3ccn12)[C@@H]1C[C@H]1c1nc2c(C)ncc(C)n2n1

Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...

Human PDE10A1 (GenBank Accession No. NM_001130690), a.a. 2-789(end) with N-terminal GST-tag, MW=116 kDa, expressed in Sf9 cells via a Baculovirus expression system. One unit is defined as the amount of enzyme that will convert 1 pmole of 3',5'-cAMP to 5'- AMP per min at 37°C. Assay condition: 10 mM Tris-HCl, pH 7.4,...

The PDE10A Assay Kit is designed for identification of PDE10A inhibitors using fluorescence polarization. The assay is based on the binding of a fluorescent nucleotide monophosphate generated by PDE10A to the binding agent. PDE10A is a dual substrate PDE highly expressed in striatal medium spiny neurons. PDE10A...

Active human PDE10A2 (GenBank Accession No. NM_006661), full length with N-terminal GST tag, MW= 116 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

Papaverine (Cay-10011133) is an analytical reference standard categorized as a muscle relaxant. Papaverine has been found as an impurity in seized heroin. This product is intended for research and forensic applications.Formal Name: 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy isoquinoline. CAS Number: 58-74-2....

TAK-063 is a potent inhibitor of phosphodiesterase 10A (PDE10A, IC50 = 0.3 nM). It is >15,000-fold selective for PDE10A over other PDEs and exhibits 14276, Cay-ISO60194) with a minimum effective dose (MED) of 0.3 mg/kg, p.o., in wild-type mice but has no effect in PDE10A knockout mice at doses up to 1 mg/kg. TAK-063...