37 products were found matching "K18436"!

Description: PDE7 inhibitor S14 is a cell-permeable PDE7 inhibitor that acts by targeting the cyclic adenosine monophosphate (cAMP)/cAMP-response element-binding protein (CREB) pathway. Target: Others. Smiles: O=C1N(C(=S)NC2=CC=CC=C12)C1=CC=CC=C1. References: Bartolome F, de la Cueva M, Pascual C, Antequera D,...

Description: BRL-50481 is a novel and selective PDE7 inhibitor with IC50 values of 0.15 µM for PDE7A, 12.1 µM for PDE7B, 62 µM for PDE4, and 490 µM for PDE3. Target: PDE. Smiles: CN(C)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O. References: Safavi M, et al. New methods for the discovery and synthesis of PDE7 inhibitors as new...

Description: Theophylline-d6 is intended for use as an internal standard for the quantification of theophylline by GC- or LC-MS. Theophylline is an inhibitor of phosphodiesterase. It is also an adenosine A1 and A2 receptor antagonist. Theophylline induces relaxation of isolated cat bronchial smooth muscle segments...

Active human PDE7A1 GenBank Accession No. NM_002603), (a.a. 121-end) with N-terminal GST tag, MW=66 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

Theophylline is a methylxanthine alkaloid that is a competitive inhibitor of phosphodiesterase (PDE, Ki = 100 µM). It is also a non-selective antagonist of adenosine A receptors (Ki = 14 µM for A1 and A2). Theophylline induces relaxation of feline bronchiole smooth muscle precontracted with acetylcholine (EC40 = 117...

BRL 50481 is a potent, selective inhibitor of phosphodiesterase (PDE) 7, inhibiting human recombinant PDE7A1 with a Ki value of 180 nM. It is much less effective against PDE3 and PDE4 and is without effect against PDE1B, PDE1C, PDE2, and PDE5. Through its effects on PDE7A1, BRL 50481 enhances the inhibitory effects...

Active human PDE7B GenBank Accession No. NM_018945), (a.a. 107-end) with N-terminal GST tag, MW=66 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

Protein function: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction. [The UniProt Consortium]

Protein function: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain. [The UniProt Consortium]

Mouse PDE7A (GenBank Accession No. NM_001122759), a.a. 147-482(end), with N-terminal GST-tag, MW=65 kDa, expressed in a Baculovirus-infected Sf9 cell expression system. 1 unit is defined as the amount of enzyme that wi

Mouse PDE7B (GenBank Accession No. NM_013875), a.a. 108-446(end), with N-terminal GST-tag, MW=65 kDa, expressed in a Baculovirus-infected Sf9 cell expression system. Assay condition: 10 mM Tris-HCl, pH 7.4, 10 mM MgCl2,

Rat PDE7A (GenBank Accession No. NM_031080), amino acids 147-482(end), with N-terminal GST-tag, MW=65 kDa, expressed in a Baculovirus-infected Sf9 cell expression system. Specific Activity is 354 pmol/min/µg.