27 products were found matching "K18283"!

Description: cGMP-dependent 3',5'-cyclic phosphodiesterase, also known as cyclic GMP-stimulated phosphodiesterase and PDE2A, is a peripheral membrane protein that belongs to the cyclic nucleotide phosphodiesterase family and PDE2 subfamily. Phosphodiesterases (PDEs) comprise a family of enzymes that regulate the...

Description: PF-05180999 is an inhibitor of phosphodiesterase 2A (IC50: 1.6 nM). Target: PDE. Smiles: Cc1nc(-c2cnn(C)c2-c2ccc(cn2)C(F)(F)F)c2c(ncnn12)N1CCC1. References: Helal CJ, et al. Identification of a Potent, Highly Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor Clinical Candidate. J Med Chem....

Active human PDE2A1 (GenBank Accession No. NM_002599), full length, with N-terminal GST tag, MW=132 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

Human PDE2A (GenBank Accession No. NM_002599), amino-acids 2-941, with N-terminal FLAG tag, MW=106 kDa, expressed in a Baculovirus infected Sf9 cell expression system. Assay conditions: 10 mM Tris-HCl, pH 7.4, 10 mM Mg

Protein function: Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. [The UniProt Consortium]

Murine PDE2A, variant 1 (GenBank Accession No. NM_001143848), a.a 2-939 (end), with N-terminal GST tag, MW=132 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

Murine PDE2A, variant 2 (GenBank Accession No. NM_001008548), a.a 2-935, with N-terminal GST tag, MW=132 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

Murine PDE2A, variant 4 (GenBank Accession No. NM_001243757), a.a. 2-939 (end), with N-terminal GST tag, MW=132 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

Rat PDE2A (GenBank Accession No. NM_00143847), full length, with N-terminal His-GST tag, MW=133 kDa, expressed in a Baculovirus infected Sf9 cell expression system

The PDE2A Assay Kit is designed for identification of PDE2A inhibitors using fluorescence polarization. The assay is based on the binding of a fluorescent nucleotide monophosphate generated by PDE2A to the binding agent. PDE2A plays an important role in dynamic regulation of cAMP signaling in the cardiovascular...

The PDE2A Assay Kit is designed for identification of PDE2A inhibitors using fluorescence polarization.The assay is based on the binding of a fluorescent nucleotide monophosphate generated by PDE2A to the binding agent. PDE2A catalyzes the hydrolysis of the phosphodiester bond in dye-labeled cyclic adenosine...

Carbazeran is an inhibitor of phosphodiesterase 2 (PDE2) and PDE3. It inhibits cAMP hydrolysis (IC50 = 4.1 µM in rabbit heart ventricles) selectively over cGMP hydrolysis (IC50 = 171 µM). It induces positive inotropic (EC50 = 100 µM) and negative chronotropic effects in isolated rabbit papillary muscle and right...