119 products were found matching "K17689"!
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4-hydroxy Alprazolam
Item number: Cay15878-1
Alprazolam is a benzodiazepine with anxiolytic and sedative actions. 4-Hydroxyalprazolam is a major metabolite of alprazolam, produced by the actions of cytochrome P450 (CYP) isoforms CYP3A4 and CYP3A5. It may be detected in serum or, in a glucuronidated form, in urine. Alternatively, 4-hydroxyalprazolam can be...
| Keywords: | 8-chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-ol |
| Application: | Alprazolam metabolite |
| CAS | 30896-57-2 |
| MW: | 324.8 D |
From 61.00€
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6-hydroxy Buspirone
Item number: TGM-T83909-50mg
Description: 6-Hydroxy Buspirone, an active metabolite of the anxiolytic compound buspirone, is produced via the cytochrome P450 (CYP) isoform CYP3A4. This compound exhibits affinity for the serotonin (5-HT) receptor subtype 5-HT1A, demonstrating efficacy in the rat hippocampus and dorsal raphe with half-maximal...
| Keywords: | BMY 28674, BMS-52821 |
| Application: | Active buspirone metabolite |
| CAS | 125481-61-0 |
| MW: | 401.5 D |
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6beta-hydroxy Prednisolone
Item number: TGM-T84930-10mg
Description: 6beta-Hydroxy Prednisolone, the active metabolite of prednisone and a derivative of prednisolone, is predominantly synthesized via the cytochrome P450 (CYP) isoform CYP3A4 and, to a lesser extent, CYP3A5. Target: Others. Smiles:...
| Application: | Prednisolone metabolite |
| CAS | 16355-29-6 |
| MW: | 376.44 D |
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CYP3A4 Protein, Human, Recombinant (His)
Item number: TGM-TMPY-05321-100ug
Description: CYP3A4 is an important member of the cytochrome P450 enzyme superfamily, with 33 allelic variants. Human cytochrome P450 3A4 (CYP3A4) is an important drug metabolizing enzyme involved in a number of drug-drug and food-drug interactions. Systemic inflammation has been linked to suppressed CYP3A4 activity.
| Keywords: | CP34, CYPIIIA4, P450C3, P450PCN1, cytochrome P450 family 3 subfamily A member 4, CYP3A, CYP3A3, CYPIIIA3, NF-25, HLP, CP33 |
| MW: | 59.2 kD |
From 699.00€
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ML368
Item number: TGM-T25823-1mg
Description: ML368 is a selective inhibitor of CYP3A4. Target: Others. Smiles: O=C(Nc1ccc(cc1)-c1ccc(cc1)C#N)Nc1ccc(cc1)-c1ccnc2[nH]cnc12. References: Cameron M, Kamenecka T, Madoux F, Chase P, Roush W, Hodder P, Griffin PR. ML368 Identification of Imidazopyridines as Selective Inhibitors of the Cytochrome P450...
| Keywords: | SR-9186, ML 368, SR9186, SR 9186, ML-368 |
| Application: | Selective CYP3A4 inhibitor |
| CAS | 1361414-26-7 |
| MW: | 430.46 D |
1,289.00€
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alpha-Hydroxytamoxifen
Item number: TGM-T19192-10mg
Description: alpha-Hydroxytamoxifen, a metabolite of tamoxifen, reacts with DNA and forms DNA adducts. Target: Others. Smiles: C(=C(/C(C)O)\C1=CC=CC=C1)(\C2=CC=C(OCCN(C)C)C=C2)/C3=CC=CC=C3. References: Phillips DH, et al. alpha-Hydroxytamoxifen, a metabolite of tamoxifen with exceptionally high DNA-binding activity...
| Keywords: | alpha-OHTAM, (E)-alpha-Hydroxy tamoxifen |
| Application: | Reactive tamoxifen metabolite |
| CAS | 97151-02-5 |
| MW: | 387.51 D |
From 77.00€
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Axitinib sulfoxide
Item number: TGM-T21129-1mg
Description: Axitinib sulfoxide is a major metabolite of Axitinib, which is a VEGFR tyrosine kinase inhibitor and may be useful in cancer therapy. Target: Others. Smiles: C(=C/C1=CC=CC=N1)\C=2C=3C(=CC(S(=O)C4=C(C(NC)=O)C=CC=C4)=CC3)NN2. References: Slobbe P, Poot AJ, Haumann R, Schuit RC, Windhorst AD, van Dongen...
| Keywords: | PF-03482595, AG-028458, Axitinib metabolite M12 |
| Application: | Major inactive metabolite |
| CAS | 1347304-18-0 |
| MW: | 402.47 D |
From 154.00€
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21-hydroxy Eplerenone
Item number: TGM-T36129-1mg
Description: 21-hydroxy Eplerenone is a major metabolite of the mineralocorticoid receptor antagonist eplerenone . It is formed from eplerenone by the cytochrome P450 (CYP) isoform CYP3A4. Target: Others. Smiles:...
| Application: | Major eplerenone metabolite |
| CAS | 334678-67-0 |
| MW: | 430.497 D |
839.00€
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N-Desethyl Vardenafil
Item number: TGM-T35714-1mg
Description: N-Desethyl vardenafil is a metabolite of vardenafil , a phosphodiesterase 5 inhibitor, that is formed by the action of cytochrome P450 (CYP)3A4 and CYP3A5. Target: Others. Smiles: O=C1N=C(NN2C(=NC(=C12)C)CCC)C=3C=C(C=CC3OCC)S(=O)(=O)N4CCNCC4
| Application: | Vardenafil metabolite |
| CAS | 448184-46-1 |
| MW: | 460.55 D |
From 77.00€
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N-desmethyl Eletriptan
Item number: TGM-T35715-1mg
Description: N-Desmethyl Eletriptan, a metabolite of eletriptan, is primarily formed from eletriptan by the cytochrome P450 (CYP) isoform CYP3A4 in human liver microsomes. Target: Others. Smiles: O=S(=O)(CCc1ccc2[nH]cc(C[C@H]3CCCN3)c2c1)c1ccccc1. References: Evans, D.C., O'Connor, D., Lake, B.G., et al.Eletriptan...
| Application: | Eletriptan metabolite |
| CAS | 153525-55-4 |
| MW: | 368.5 D |
266.00€
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4-hydroxy Atorvastatin (calcium salt)
Item number: TGM-T35724-1mg
Description: 4-hydroxy Atorvastatin is a metabolite of atorvastatin , an HMG-CoA reductase inhibitor present in formulations that have been used to treat hypercholesterolemia and certain dyslipidemias. Atorvastatin is metabolized by the cytochrome P450 (CYP) isoform CYP3A4 to form 4-hydroxy atorvastatin. Target:...
| Application: | Atorvastatin metabolite |
| CAS | 265989-44-4 |
| MW: | 1191.393 D |
From 198.00€
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Monocrotaline
Item number: TGM-T2803-100mg
Description: Monocrotaline (Crotaline) is a pyrrolizidine alkaloid and a toxic plant constituent that poisons livestock and humans through the ingestion of contaminated grains and other foods. The alkaloid causes pulmonary artery hypertension, right ventricular hypertrophy, and pathological changes in the pulmonary...
| Keywords: | Crotaline |
| Application: | Pulmonary hypertension inducer |
| CAS | 315-22-0 |
| MW: | 325.36 D |
From 42.00€
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