30 products were found matching "K16835"!

Description: Anacetrapib (MK-0859) (MK0859) is an effective, specific, reversible rhCETP and mutant CETP(C13S) inhibitor (IC50: 7.9 nM and 11.8 nM). Anacetrapib reduces the transfer of cholesteryl ester from HDL to LDL and/or VLDL thereby, producing an increase in serum HDL-cholesterol levels and a decrease in serum...

Description: Obicetrapib (AMG-899) is an inhibitor of cholesteryl ester transfer protein. Target: CETP. Smiles: N(CC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)([C@@H]2C=3C(N(C(OCC)=O)[C@H](CC)C2)=CC=C(C(F)(F)F)C3)C=4N=CC(OCCCC(O)=O)=CN4. References: Filippatos TD, et al. Cholesteryl ester transfer protein inhibitors: challenges...

Description: Dalcetrapib (RO4607381), a rhCETP inhibitor (IC50=0.2 µM), increases the plasma HDL cholesterol. Target: CETP. Smiles: CCC(CC)CC1(CCCCC1)C(=O)Nc1ccccc1SC(=O)C(C)C. References: Niesor EJ, et al. J Lipid Res. 2010, 51(12), 3443-3454.

Description: Evacetrapib (LY2484595) (LY2484595) is a potent and selective inhibitor of CETP with IC50 of 5.5 nM, elevates HDL cholesterol without increases in aldosterone or blood pressure. Phase 3. Target: CETP. Smiles:...

Description: Obicetrapib calcium is a cholesteryl ester transfer protein (CETP) inhibitor. CETP inhibitors substantially increase the concentration of high-density lipoprotein cholesterol (HDL-C), which may have a possible beneficial effect for cardiovascular disease risk reduction. Target: Others

Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 18-493aa. Protein Length: Full Length of Mature Protein. Tag Info: N-terminal MBP-tagged and C-terminal 6xHis-tagged. Target Protein Sequence: CSKGTSHEAG IVCRITKPAL LVLNHETAKV IQTAFQRASY PDITGEKAMM LLGQVKYGLH NIQISHLSIA SSQVELVEAK SIDVSIQNVS...

Anacetrapib is an inhibitor of cholesterol ester transfer protein (CETP) with IC50 values of 17 and 15 nM for CETP-dependent transfer of cholesterol esters and triglycerides, respectively. It decreases plasma levels of LDL and triglycerides, reduces atherosclerotic lesion sizes, and increases HDL levels in the...

Evacetrapib is a benzazepine inhibitor of cholesteryl ester transfer protein (CETP, IC50s = 5.5 and 26 nM for human recombinant and plasma-derived proteins, respectively). It is selective for CETP over a panel of cell surface and nuclear receptors with no significant inhibition at 1 µM. Evacetrapib (1-10 µM) reduces...

Torcetrapib is an inhibitor of cholesteryl ester transfer protein (CETP, IC50s = 47 and 51 nM for cholesteryl and triglyceride transfer, respectively). It is selective for CETP over phospholipid transfer protein (PLTP), lecithin:cholesterol acyltransferase (LCAT), and hepatic and lipoprotein lipases at 10 µM....

Protein function: Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride...

Protein function: Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride...