36 products were found matching "K15719"!

TP-040 is an O-GlcNAcase (OGA) inhibitor (IC50 = 46 nM). It is selective for OGA over beta-hexosaminidase (IC50 = >10 µM) and a panel of 277 kinases (IC50s = >1 µM for all). TP-040 increases the levels of O-GlcNAcylated proteins in SH-SY5Y neuroblastoma cells (EC50 = 450 nM).Formal Name:...

Description: (Z)-PUGNAc, a potent O-GlcNAcase inhibitor more active than (E)-PUGNAc, removes O-GlcNAc from proteins (peptide O-GlcNAc-beta-N-acetylaminoglucosidase) and can be used to increase levels of O-GlcNAc on nuclear and cytoplasmic proteins in vivo. Target: Others. Smiles:...

Description: NAG-thiazoline (GlcNAc-thiazoline) is an O-GlcNAcase inhibitor with Ki value of 180 nM. It is active against V. campbellii with MIC value of 0.5 µM. Target: Others. Smiles: O[C@@H]1[C@@]2([C@](O[C@H](CO)[C@H]1O)(SC(C)=N2)[H])[H]. References: NAG-thiazoline is a potent inhibitor of the Vibriocampbellii...

Description: Thiamet G is a potent, selective O-GlcNAcase inhibitor with Kiof 21 nM, while exhibiting 37, 000-fold selectivity over human lysosomal -hexosaminidase. Target: Autophagy, Others. Smiles: [H][C@]12O[C@H](CO)[C@@H](O)[C@H](O)[C@@]1([H])N=C(NCC)S2. References: Yuzwa SA, et al. Nat Chem Biol. 2008, 4(8),...

The kit is a Sandwich enzyme immunoassay for in vitro quantitative measurement of NAGase in serum, plasma and other biological fluids. Detection Range: 1.56--100ng/mL. Sensitivity: 0.94ng/mL. Protein function: Isoform 1: Cleaves GlcNAc but not GalNAc from O- glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc...

Description: MK-8719 is a highly potent and selective inhibitor of O-GlcNAcase (OGA) [hOGA], with a Ki value of 7.9 nM. Target: Others. Smiles: [H][C@]12O[C@H](C(F)F)[C@@H](O)[C@H](O)[C@@]1([H])N=C(NCC)S2. References: Selnick HG, et al. Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment...

Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: MGEA5. Antigen Species: Human

Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: MGEA5. Antigen Species: Human

MK-8719 is an inhibitor of O-GlcNAcase (OGA, Ki = 7.9 nM for the human enzyme). It is selective for OGA over beta-hexosaminidase (Ki = >10,000 nM for the human enzyme). MK-8719 increases the levels of O-GlcNAcylated proteins in rat PC12 adrenal medulla cells (EC50 = 52.7 nM). It increases brain levels of...

Hyperphosphorylation of the tau protein leads to its aggregation and formation of neurofibrillary tangles, a hallmark of Alzheimer's disease and other tauopathic, neurodegenerative disorders. Tau is also dynamically modified by the addition and cleavage of O-linked beta-N-acetylglucosamine (O-GlcNAc) moieties, which...

Proteins can be modified post-translationally by the addition of O-linked N-acetylglucosamine (O-GlcNAc). Nuclear cytoplasmic O-GlcNAcase and acetyltransferase (NCOAT) is a beta-N-acetylglucosaminidase that removes GlcNAc from O-glycosylated proteins. PUGNAc is a (phenylcarbamoyl)oxime analog of GlcNAc that...

Protein function: Isoform 1: Cleaves GlcNAc but not GalNAc from O- glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4- methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl- beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone...