45 products were found matching "K14963"!

Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 2-334aa. Protein Length: Full Length of Mature Protein. Tag Info: N-terminal 6xHis-SUMO-tagged. Target Protein Sequence: ATEEKKPETE AARAQPTPSS SATQSKPTPV KPNYALKFTL AGHTKAVSSV KFSPNGEWLA SSSADKLIKI WGAYDGKFEK TISGHKLGIS DVAWSSDSNL LVSASDDKTL...

WDR5-MYC probe 12 is an inhibitor of the protein-protein interaction between the master transcription factor Myc and WD repeat domain 5 (WDR5, IC50 = 0.39 µM). It reduces mRNA expression of the Myc and WDR5 co-binding target genes ribosomal protein L17 (RPL17), RPL23, RPL35, and RPL37A in HL-60 cells. WDR5-MYC probe...

Protein function: Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic...

WD-repeat protein 5 (WDR5) is a scaffold protein commonly involved in the formation of nucleosome-modifying protein complexes with histones. It serves as a component of a mixed-lineage leukemia (MLL) methyltransferase complex that targets histone 3 at lysine 4 to upregulate transcription. MM-102 is a potent WDR5/MLL...

Protein function: Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic...

WD-repeat protein 5 (WDR5) is a scaffold protein commonly involved in the formation of nucleosome-modifying protein complexes with histones. For example, WDR5 is a component of a mixed-lineage leukemia (MLL) methyltransferase complex that targets histone 3. WDR5 can also be a component of histone acetyltransferase...

Human WDR5 (WD Repeat Domain 5), also known as SWD3 or BIG-3, GenBank Accession No. NM_017588, amino acids 2-334(end), with N-terminal His-tag, MW=37.5 kDa, expressed in Sf9 insect cells via a baculovirus expression system.

WD repeats are motifs of approximately 40 amino acids typically terminating in conserved tryptophan and aspartate residues. Several WD40 repeats combine to form the structural WD domain. Such an arrangement facilitates protein-protein interactions allowing the formation of multiprotein complexes. Human WDR5 contains...

WD-repeat protein 5 (WDR5) is a scaffold protein commonly involved in the formation of nucleosome-modifying protein complexes with histones. For example, WDR5 is a component of a mixed-lineage leukemia (MLL) methyltransferase complex that targets histone 3. WDR5 can also be a component of histone acetyltransferase...

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Human WDR5 (WD Repeat Domain 5), also known as SWD3 or BIG-3, GenBank Accession No. NM_017588, a.a. 2-334(end), with N-terminal FLAG-tag, MW=37 kDa, expressed in a baculovirus-infected Sf9 insect expression system.

Human WDR5 (WD Repeat Domain 5), also known as SWD3 or BIG-3, GenBank Accession No. NM_017588, a.a. 2-334(end), with N-terminal Avi-His-tag, MW=39 kDa, expressed in Sf9 insect cells via a baculovirus expression system. This protein is enzymatically biotinylated using Avi-Tag(TM) technology. Biotinylation is...