179 products were found matching "K13293"!
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Tofimilast
Item number: TGM-T28991-100mg
Description: Tofimilast (CP-325366), a PDE4 inhibitor, is used potentially for the treatment of asthma and chronic obstructive pulmonary disease. Target: PDE. Smiles: C(C)C=1C2=C(C=3N(C(=NN3)C4=CC=CS4)CC2)N(N1)C5CCCC5. References: Jaffari S, et al. Rapid characterisation of the inherent dispersibility of respirable...
| Keywords: | CP 325,366, CP 325366, CP325366, CP-325,366, CP-325366 |
| Application: | Targets cAMP-specific phosphodiesterase 4 [EC:3.1.4.53] (PDE4) |
| CAS | 185954-27-2 |
| MW: | 339.46 D |
From 143.00€
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Apremilast
Item number: TGM-T2923-100mg
Description: Apremilast (CC-10004) (CC-10004) is a potent and orally active PDE4 (IC50=74 nM) with anti-inflammation activities. Target: PDE, TNF, Apoptosis. Smiles: [C@H](CS(C)(=O)=O)(N1C(=O)C=2C(C1=O)=CC=CC2NC(C)=O)C3=CC(OCC)=C(OC)C=C3. References: Perez-Aso M, et al. Apremilast, a novel phosphodiesterase 4...
| Keywords: | CC-10004 |
| Application: | Targets cAMP-specific phosphodiesterase 4 [EC:3.1.4.53] (PDE4) |
| CAS | 608141-41-9 |
| MW: | 460.5 D |
From 43.00€
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Difamilast
Item number: TGM-T27172-100mg
Description: Difamilast is a selective inhibitor of phosphodiesterase-4 (PDE4) with particularly efficient inhibition of subtype B (IC50=11.2 nM). Target: PDE. Smiles: CCOc1ccccc1C(=O)NCc1coc(n1)-c1ccc(OC(F)F)c(OC(C)C)c1. References: Ahluwalia J, et, al. Phosphodiesterase 4 Inhibitor Therapies for Atopic Dermatitis:...
| Application: | Targets cAMP-specific phosphodiesterase 4 [EC:3.1.4.53] (PDE4) |
| CAS | 937782-05-3 |
| MW: | 446.44 D |
From 129.00€
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GSK356278
Item number: TGM-T27475-100mg
Description: GSK356278 is an effective and selective inhibitor of phosphodiesterase 4 (PDE4), with pIC50s of 8.6, 8.8, and 8.7 for human PDE4A, PDE4B, and PDE4D, respectively. GSK356278 has anti-inflammatory, anxiolytic, and cognition-enhancing effects. Target: PDE. Smiles:...
| Keywords: | GSK-356278, GSK 356278 |
| Application: | Potent, selective PDE4 inhibitor |
| CAS | 720704-34-7 |
| MW: | 439.53 D |
From 34.00€
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O-Demethyl Apremilast
Item number: TGM-T35929-10mg
Description: O-Demethyl apremilast is an active metabolite of the phosphodiesterase 4 (PDE4) inhibitor apremilast .1It inhibits the activity of PDE4 isolated from U937 cells and LPS-induced TNF-alpha production in isolated human peripheral blood mononuclear cells (PBMCs, IC50s = 8.3 and 5.6 µM, respectively)....
| Application: | Apremilast active metabolite, PDE4 inhibitor |
| CAS | 1384441-38-6 |
| MW: | 446.47 D |
From 151.00€
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Phosphodiesterase 4 Inhibitor
Item number: TGM-T36018-10mg
Description: Phosphodiesterase 4 (PDE4) inhibitor is an inhibitor of PDE4 with an IC50 value of 0.10 µM for the human recombinant enzyme. Target: Others. Smiles: CC=1N(N=C(C)C1C(OCC)=O)C2=CC(N(=O)=O)=CC=C2
| Application: | PDE4 inhibitor |
| CAS | 346440-86-6 |
| MW: | 289.29 D |
From 321.00€
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Tanimilast
Item number: TGM-T38625-100mg
Description: Tanimilast (CHF-6001) is a novel, potent, and selective phosphodiesterase 4 inhibitor with an IC50 value of 0.026 ± 0.006 nM. It exhibits potent anti-inflammatory activity and is indicated for topical use in the lungs. Tanimilast was studied for its effects on obstructive lung disease. Target: PDE....
| Keywords: | CHF-6001 |
| Application: | Targets cAMP-specific phosphodiesterase 4 [EC:3.1.4.53] (PDE4) |
| CAS | 1239278-59-1 |
| MW: | 687.54 D |
From 274.00€
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CP671305
Item number: TGM-T4695-100mg
Description: CP671305 is an orally active, potent and selective inhibitor of phosphodiesterase-4-D. Target: PDE. Smiles: C[C@@H](Oc1ccc(CNC(=O)c2cccnc2Oc2ccc3OCOc3c2)c(F)c1)C(O)=O. References: Kalgutkar AS, et al. Role of transporters in the disposition of the selective phosphodiesterase-4 inhibitor...
| Application: | PDE4D inhibitor |
| CAS | 445295-04-5 |
| MW: | 454.4 D |
From 32.00€
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Crisaborole
Item number: TGM-T4285-100mg
Description: Crisaborole (AN-2728) is a phosphodiesterase 4 inhibitor. Target: PDE. Smiles: OB1OCc2cc(Oc3ccc(cc3)C#N)ccc12. References: Akama T, et al. Discovery and structure-activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic...
| Keywords: | PF-06930164, AN-2728 |
| Application: | Targets cAMP-specific phosphodiesterase 4 [EC:3.1.4.53] (PDE4) |
| CAS | 906673-24-3 |
| MW: | 251.05 D |
From 38.00€
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Roflumilast N-oxide
Item number: TGM-T4462-100mg
Description: Roflumilast N-oxide is an inhibitor of PDE type 4. Target: PDE. Smiles: [O-][n+]1cc(Cl)c(NC(=O)c2ccc(OC(F)F)c(OCC3CC3)c2)c(Cl)c1. References: Victoni T,etal.Roflumilast n-oxide associated with PGE2 prevents the neutrophil elastase-induced production of chemokines by epithelial cells.Int Immunopharmacol....
| Application: | PDE4 inhibitor |
| CAS | 292135-78-5 |
| MW: | 419.21 D |
From 31.00€
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D159687
Item number: TGM-T5474-100mg
Description: D159687 is a selective PDE4D inhibitor,had a procognitive profile as it improved memory in the novel object recognition test but had no antidepressant or anxiolytic benefit. Target: PDE. Smiles: COc1ccc(Cc2ccc(NC(N)=O)cc2)cc1-c1cccc(Cl)c1. References: Zhang C, et al. Comparison of the Pharmacological...
| Keywords: | D 159687 |
| Application: | Negative allosteric PDE4D modulator |
| CAS | 1155877-97-6 |
| MW: | 366.84 D |
From 47.00€
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Cipamfylline
Item number: TGM-T70974-100mg
Description: Cipamfylline is a xanthine, a theophylline analogue, and is a potent and selective inhibitor of phosphodiesterase type 4 (PDE-4). Cipamfylline was tested in patients with a diagnosis of atopic dermatitis and in two human models of acute and chronic irritant contact dermatitis. The outcome of the study...
| Application: | Targets cAMP-specific phosphodiesterase 4 [EC:3.1.4.53] (PDE4) |
| CAS | 132210-43-6 |
| MW: | 275.31 D |
From 1,491.00€
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