148 products were found matching "K12654"!
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STING Y240A variant (Y240A mutant, human, recombinant)
Item number: Cay40240-100
Stimulator of interferon genes (STING) is a component of the innate immune response that recognizes and binds to cyclic dinucleotides (CDNs), which either originate from bacteria or are signals of intracellular stress, leading to activation of NF-kappaB and transcription of immunomodulatory genes, including type I...
| Keywords: | ERIS, ERIS, hMITA, hMITA, hSTING, hSTING, Transmembrane protein 173, Transmembrane protein 173, Mediator of IRF3... |
| Expressed in: | E.coli |
| Origin: | human |
806.00€
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ZINC03129319
Item number: TGM-T13397-2mg
Description: ZINC03129319 is an inhibitor of dengue virus (DENV) NS2B-NS3 protease. Target: Virus Protease. Smiles: O=C1C2(N3[C@](CS2)(C(=O)N4[C@@](C3=O)(CSC45C(=O)C=6C(C5=O)=CC=CC6)[H])[H])C(=O)C=7C1=CC=CC7. References: Watowich, Stanley J, et al. SMALL-MOLECULE INHIBITORS OFDENGUE VIRUS PROTEASES. US20150141521A1.
| Application: | STING activator |
| CAS | 1777807-64-3 |
| MW: | 490.51 D |
From 31.00€
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STING agonist-3
Item number: TGM-T13014-10mg
Description: STING agonist-3 is a selective and non-nucleotide small-molecule STING agonist(pEC50 and pIC50 of 7.5 and 9.5, respectively), has durable anti-tumor effect and tremendous potential to improve treatment of cancer. Target: Others. Smiles:...
| Application: | STING agonist |
| CAS | 2138299-29-1 |
| MW: | 750.81 D |
From 151.00€
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STING agonist-4
Item number: TGM-T13015-1mg
Description: STING agonist-4 is an agonist of stimulator of Interferon Genes (STING) receptor (IC50: 20 nM). Target: STING. Smiles: CCn1nc(C)cc1C(=O)Nc1nc2cc(ccc2n1CCCCn1c(NC(=O)c2cc(C)nn2CC)nc2cc(ccc12)C(N)=O)C(N)=O. References: Ramanjulu JM et al. Design of amidobenzimidazole STING receptor agonists with systemic...
| Application: | STING agonist |
| CAS | 2138300-40-8 |
| MW: | 678.74 D |
From 159.00€
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cGAMP
Item number: TGM-T13606-25mg
Description: cGAMP is an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. It also is a STING ligand. Target: Others. Smiles:...
| Keywords: | 3',3'-cGAMP, Cyclic GMP-AMP |
| Application: | Potent STING ligand, Second messenger |
| CAS | 849214-04-6 |
| MW: | 674.41 D |
1,491.00€
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CAY10748
Item number: TGM-T36461-10mg
Description: CAY10748 is an agonist of stimulator of interferon genes (STING, IC50= 0.3794 µM in a competition binding assay).1It activates STING in STING-expressing, but not STING knockout, THP-1 cells (EC50s = 0.287 and >100 µM, respectively, in a reporter assay). It induces phosphorylation of STING at the serine...
| Keywords: | CAY10748 |
| Application: | STING stimulator |
| CAS | 2412902-55-5 |
| MW: | 591.66 D |
From 120.00€
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Cyclic-di-GMP disodium
Item number: TGM-T36983-10mg
Description: Cyclic-di-GMP disodium (5GP-5GP disodium) is a bacterial second messenger and a STING agonist involved in a variety of prokaryotic processes including biofilm formation, motility, and cell cycle progression.Cyclic-di-GMP disodium displays antiproliferative activity against cancer cells, inducing...
| Keywords: | 5GP-5GP disodium, 3',5'-Cyclic diguanylic acid, Cyclic diguanylate, c-di-GMP, Cyclic di-GMP (sodium salt), cyclic... |
| Application: | Second messenger in bacteria |
| CAS | 2222132-40-1 |
| MW: | 734.38 D |
From 136.00€
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STING Agonist 12b
Item number: TGM-T38159-10mg
Description: STING agonist 12b is an agonist of stimulator of interferon genes (STING).1It binds to STING (Kd= 26.4 µM) and induces interferon reporter gene expression in cells expressing human or mouse STING (EC50s = 7.45 and 10.23 µM, respectively). STING agonist 12b (40 µM) induces expression of TNF-a, IL-6,...
| Application: | Stimulator of interferon genes protein activator |
| CAS | 2411100-70-2 |
| MW: | 253.3 D |
From 120.00€
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STING Agonist 1a
Item number: TGM-T38160-10mg
Description: STING agonist 1a is an agonist of stimulator of interferon genes (STING).1It induces expression of an IRF-inducible SEAP reporter gene in a cell-based assay (EC50= 16.77 µM). STING agonist 1a (12.5-100 µM) induces expression of IFN-beta, IL-6, and chemokine (C-X-C motif) ligand 10 (CXCL10) in THP-1...
| Application: | Stimulator of interferon genes protein activator |
| CAS | 652142-94-4 |
| MW: | 396.23 D |
From 120.00€
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C-176
Item number: TGM-T5154-100mg
Description: C-176 (STING inhibitor 1) is a STING inhibitor with selectivity and blood-brain barrier permeability. C-176 inhibits STING-mediated IFNbeta production and possesses anti-inflammatory activity. Target: STING. Smiles: [O-][N+](=O)c1ccc(o1)C(=O)Nc1ccc(I)cc1. References: Haag SM, et al. Targeting STING with...
| Keywords: | STING inhibitor 1, C176 |
| Application: | Covalent STING inhibitor |
| CAS | 314054-00-7 |
| MW: | 358.09 D |
From 31.00€
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diABZI STING agonist-1 trihydrochloride
Item number: TGM-T5516-100mg
Description: diABZI STING agonist-1 (trihydrochloride) is a stimulator of interferon genes (STING) receptor agonist. Target: STING. Smiles: Cl.Cl.Cl.CCn1nc(C)cc1C(=O)Nc1nc2cc(cc(OC)c2n1C\C=C\Cn1c(NC(=O)c2cc(C)nn2CC)nc2cc(cc(OCCCN3CCOCC3)c12)C(N)=O)C(N)=O. References: Ramanjulu JM, et al. Design of amidobenzimidazole...
| Application: | Stimulator of interferon genes pathway agonist |
| CAS | 2138299-34-8 |
| MW: | 959.32 D |
From 171.00€
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H-151
Item number: TGM-T5674-100mg
Description: H-151 is a highly potent and selective STING antagonist. H-151 covalently binds to Cys91 of STING and inhibits palmitoylation of Cys91, thereby inhibiting STING activity. H-151 can be used in the study of autoinflammatory diseases in vivo and ex vivo. Target: STING. Smiles:...
| Application: | STING inhibitor |
| CAS | 941987-60-6 |
| MW: | 279.34 D |
From 31.00€
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