115 products were found matching "K12654"!

NVS-STG2 is an agonist of stimulator of interferon genes (STING). It binds to STING and induces STING activation in a reporter assay (IC50 = 5.2 µM). Intratumoral injection of NVS-STG2 (400 or 800 µg/animal) reduces tumor volume and increases intratumoral IFN-gamma levels in a B16.SIY murine melanoma model.Formal...

Stimulator of interferon genes (STING) is a component of the innate immune response that recognizes and binds to cyclic dinucleotides (CDNs), which either originate from bacteria or are signals of intracellular stress, leading to activation of NF-kappaB and transcription of immunomodulatory genes, including type I...

PDIC-NC is an activator of stimulator of interferon genes (STING) and an anticancer agent. It increases the levels of phosphorylated STING in Lewis lung carcinoma cells when used at a concentration of 2 µM. PDIC-NC decreases the viability of A549 and NCI H446 lung cancer cells (IC50s = 0.48 and 0.79 µg/ml,...

PDIC-NS is an activator of stimulator of interferon genes (STING). It increases the levels of reactive oxygen species (ROS) and induces apoptosis in LL/2 lung carcinoma cells when used at a concentration of 2.5 µM. PDIC-NS (2.5 µM) induces cell cycle arrest at the S phase, increases cytosolic levels of mitochondrial...

STING PROTAC SP23 is a proteolysis-targeting chimera (PROTAC) containing the stimulator of interferon genes (STING) inhibitor C-170 (Cay-30157) conjugated to the cereblon (CRBN) inhibitor pomalidomide (Cay-19877) via an alpha,beta-unsaturated carbonyl linker. It degrades STING in THP-1 cells with a half-maximal...

BDW568 is an agonist of stimulator of interferon genes (STING) and a prodrug form of BDW-OH. It induces STING transcriptional activity in a reporter assay using THP-1 cells (EC50 = 7.6 µM). BDW568 (50 µM) induces phosphorylation of TANK-binding kinase 1 (TBK1) and IFN regulatory factor 3 (IRF3) in THP-1 cells.Formal...

LB244 is an irreversible STING antagonist. It binds to STING in a cell-free assay and inhibits STING activation induced by the STING agonist diABZI in cells (EC50 = 0.8 nM). LB244 (1 µM) inhibits diABZI-induced STING oligomerization and phosphorylation of IFN regulatory factor 3 (IRF3) and TANK-binding kinase 1...

STING agonist D61 (D61) is an agonist of stimulator of interferon genes (STING). It induces expression of an IFN3-inducible secreted alkaline phosphatase (SEAP) reporter gene and an IFN-beta-inducible reporter gene in cell-based assays (EC50s = 52.9 and 116 nM, respectively). D61 (4, 6, and 8 µM) increases the...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human TMEM173. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human TMEM173....

STING agonist 12L is an agonist of stimulator of interferon genes (STING). It binds to wild-type STING (IC50 = 1.15 µM), as well as the STING R232, AQ, and Q variants (IC50s = 1.06, 0.61, and 1.12 µM, respectively) and induces reporter gene expression in THP-1 and RAW 264.7 cells (EC50s = 0.38 and 12.94 µM,...

SN-001 is an inhibitor of stimulator of interferon genes (STING). It inhibits herring testis DNA-induced Ifnb mRNA expression in L-929 cells (IC50 = 3.82 µM).Formal Name: N-[3-[[(4-fluorophenyl)sulfonyl]amino]-4-methoxyphenyl]-[1,1'-biphenyl]-4-carboxamide. CAS Number: 727699-84-5. Synonyms: DUN99845, Stimulator of...

STING H232 variant, SUMO-tagged contains amino acids 155-341 of the H232 variant and a removable N-terminal SUMOpro tag. Stimulator of interferon genes (STING) is a component of the innate immune response that binds to cyclic dinucleotides, which are bacterial second messengers, leading to activation of NF-kappaB...