30 products were found matching "K12351"!
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DPTIP (hydrochloride)
Item number: Cay41681-10
DPTIP is an inhibitor of neutral sphingomyelinase 2 (nSMase2, IC50 = 30 nM). It is selective for nSMase2 over alkaline phosphatase (ALP) and acid sphingomyelinase (IC50s = >100 µM for both). DPTIP reduces viral yield in Vero and HeLa cells infected with West Nile virus (EC50s = 0.26 and 2.81 µM, respectively) or...
| Keywords: | 2,6-dimethoxy-4-[4-phenyl-5-(2-thienyl)-1H-imidazol-2-yl]-phenol, monohydrochloride |
| Application: | Neutral sphingomyelinase (Sphingomyelin phosphodiesterase 2, SMPD2) inhibitor |
| CAS | 2361799-64-4 |
| MW: | 414.9 D |
From 136.00€
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GW4869
Item number: TGM-T3640-5mg
Description: GW4869 (GW69A) is a selective and non-competitive inhibitor of neutral sphingomyelinase N-SMase (IC50=1 µM). GW4869 also inhibits exosome synthesis/release and is commonly used in exosome-related studies. Target: Phospholipase. Smiles:...
| Keywords: | GW 4869, GW554869A, GW69A |
| Application: | Neutral sphingomyelinase inhibitor |
| CAS | 6823-69-4 |
| MW: | 577.5 D |
From 54.00€
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Altenusin
Item number: TGM-T8895-10mg
Description: Altenusin is a natural nonsteroidal fungal metabolite, as a novel selective agonist of FXR with an EC50 value of 3.2 ± 0.2 µM. Target: FXR. Smiles: C(O)(=O)C1=C(C=C(OC)C=C1O)C2=C(C)C=C(O)C(O)=C2. References: Zheng Z, Zhao Z, Li S, et al. Altenusin, a Nonsteroidal Microbial Metabolite, Attenuates...
| Application: | N-SMase inhibitor |
| CAS | 31186-12-6 |
| MW: | 290.27 D |
From 387.00€
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GW 4869 (hydrochloride hydrate)
Item number: Cay13127-1
Neutral sphingomyelinases mediate the release of ceramide from sphingomyelin in cellular membranes and can be activated by certain stresses. Ceramide can act as a signaling molecule in its own right, or it can be further processed to generate sphingosine (and sphingosine-1-phosphate). GW 4869 is an inhibitor of...
| Keywords: | 3,3'-(1,4-phenylene)bis[N-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-dihydrochloride-2-propenamide |
| Application: | Neutral sphingomyelinase inhibitor |
| CAS | 6823-69-4 |
| MW: | 577.5 D |
From 45.00€
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Sphingomyelin phosphodiesterase 2 (SMPD2), human,...
Item number: CSB-CF021846HU.100
Organism: Homo sapiens (Human). Source: in vitro E.coli expression system. Expression Region: 1-423aa. Protein Length: Full Length. Tag Info: N-terminal 10xHis-tagged. Target Protein Sequence: MKPNFSLRLR IFNLNCWGIP YLSKHRADRM RRLGDFLNQE SFDLALLEEV WSEQDFQYLR QKLSPTYPAA HHFRSGIIGS GLCVFSKHPI QELTQHIYTL NGYPYMIHHG...
| Keywords: | nSMase, nSMase1, N-SMase, Lyso-PAF-PLC, Neutral sphingomyelinase, Sphingomyelin phosphodiesterase 2,... |
| Application: | Activity not tested |
| Expressed in: | E.coli in vitro |
| Origin: | human |
| MW: | 49.1 kD |
From 1,458.00€
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Altenusin
Item number: AG-CN2-0143-M001
Isolated from Penicillium sp. Antibiotic. Antifungal penicillide. Non-competitive, specific neutral sphingomyelinase (N-SMase) inhibitor. Strong pp60c-Src inhibitor. Inhibits cFMS receptor tyrosine kinase (CSF-1/m-CSF receptor tyrosine kinase) which is implicated in cancer and bone diseases. Myosin light chain...
| Keywords: | MS 341 |
| Application: | N-SMase inhibitor |
| CAS | 31186-12-6 |
| MW: | 290,3 D |
From 165.00€
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Anti-SMPD2 / nSMase
Item number: ARG59500.100
Protein function: Converts sphingomyelin to ceramide. Hydrolyze 1-acyl-2- lyso-sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso- sn-glycero-3-phosphocholine (lyso-platelet-activating factor). The physiological substrate seems to be Lyso-PAF. [The UniProt Consortium]
| Keywords: | Anti-SMPD2, Anti-nSMase, Anti-N-SMase, EC=3.1.4.12, Anti-Lyso-PAF-PLC, Anti-Neutral sphingomyelinase, Anti-Sphingomyelin... |
| Application: | WB |
| Host: | Rabbit |
| Species reactivity: | mouse, rat |
658.00€
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Anti-SMPD2 / nSMase
Item number: ARG59535.100
Protein function: Converts sphingomyelin to ceramide. Hydrolyze 1-acyl-2- lyso-sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso- sn-glycero-3-phosphocholine (lyso-platelet-activating factor). The physiological substrate seems to be Lyso-PAF. [The UniProt Consortium]
| Keywords: | Anti-SMPD2, Anti-nSMase, Anti-N-SMase, EC=3.1.4.12, Anti-Lyso-PAF-PLC, Anti-Neutral sphingomyelinase, Anti-Sphingomyelin... |
| Application: | FC, WB |
| Host: | Rabbit |
| Species reactivity: | human |
616.00€
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Anti-SMPD2
Item number: E-AB-19030.120
This gene encodes a protein which was initially identified as a sphingomyelinase based on sequence similarity between bacterial sphingomyelinases and a yeast protein. Subsequent studies showed that its biological function is less likely to be as a sphingomyelinase and instead as a lysophospholipase. Protein...
| Keywords: | Anti-SMPD2, Anti-nSMase, Anti-N-SMase, EC=3.1.4.12, Anti-Lyso-PAF-PLC, Anti-Neutral sphingomyelinase, Anti-Sphingomyelin... |
| Application: | WB, IHC, ELISA |
| Host: | Rabbit |
| Species reactivity: | human, mouse, rat |
From 89.00€
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Anti-SMPD2
Item number: E-AB-52945.120
This gene encodes a protein which was initially identified as a sphingomyelinase based on sequence similarity between bacterial sphingomyelinases and a yeast protein. Subsequent studies showed that its biological function is less likely to be as a sphingomyelinase and instead as a lysophospholipase. Protein...
| Keywords: | Anti-SMPD2, Anti-nSMase, Anti-N-SMase, EC=3.1.4.12, Anti-Lyso-PAF-PLC, Anti-Neutral sphingomyelinase, Anti-Sphingomyelin... |
| Application: | WB, IHC, ELISA |
| Host: | Rabbit |
| Species reactivity: | human, mouse, rat |
From 89.00€
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Anti-SMPD2
Item number: ATA-HPA018125.100
Protein function: Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Hydrolyze...
| Keywords: | Anti-nSMase, Anti-N-SMase, Anti-nSMase1, Anti-Lyso-PAF-PLC, Anti-Neutral sphingomyelinase, Anti-Sphingomyelin... |
| Application: | ICC, IHC, WB |
| Host: | Rabbit |
| Species reactivity: | human |
From 239.00€
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Rat NSMASE (Neutral Sphingomyelinase) ELISA Kit
Item number: ELK-ELK6191.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat NSMASE. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat NSMASE. Next,...
| Keywords: | Smpd2, nSMase, N-SMase, EC=3.1.4.12, Lyso-PAF-PLC, Neutral sphingomyelinase, Sphingomyelin phosphodiesterase 2,... |
| Application: | ELISA |
| Species reactivity: | rat |
From 374.00€
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