56 products were found matching "K12318"!
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Vericiguat
Item number: TGM-T17226-100mg
Description: Vericiguat (BAY1021189) is a potent and orally available guanylate cyclase stimulator. Target: Guanylate cyclase. Smiles: COC(=O)Nc1c(N)nc(nc1N)-c1nn(Cc2ccccc2F)c2ncc(F)cc12. References: Follmann M, et al. Discovery of the Soluble Guanylate Cyclase Stimulator Vericiguat (BAY 1021189) for the Treatment...
| Keywords: | BAY1021189 |
| Application: | Targets guanylate cyclase soluble subunit alpha [EC:4.6.1.2] (GUCY1A) |
| CAS | 1350653-20-1 |
| MW: | 426.38 D |
From 42.00€
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NS-2028
Item number: TGM-T16344-100mg
Description: NS-2028 is a highly selective soluble Guanylyl Cyclase (sGC) inhibitor (IC50: 30 nM and 200 nM for basal and NO-stimulated enzyme activity) commonly used in nitric oxide signaling pathway research. It inhibits sGC activity in mouse cerebellum homogenates and neuronal NO synthase (IC50: 17 nM and 20 nM),...
| Application: | Guanylyl cyclase inhibitor |
| CAS | 204326-43-2 |
| MW: | 269.05 D |
From 34.00€
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Olinciguat
Item number: TGM-T16383-100mg
Description: Olinciguat (IW-1701) is an oral guanylate cyclase (sGC) stimulator. It also has concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole-cell assay. Target: Guanylate cyclase. Smiles: NC(=O)[C@](O)(CNc1nc(ncc1F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1)C(F)(F)F. References:...
| Keywords: | IW-1701 |
| Application: | Targets guanylate cyclase soluble subunit alpha [EC:4.6.1.2] (GUCY1A) |
| CAS | 1628732-62-6 |
| MW: | 509.39 D |
From 187.00€
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Praliciguat
Item number: TGM-T16569-100mg
Description: Praliciguat (IW-1973) stimulates sGC in HEK-293 cells (EC50: 197 nM). Praliciguat is an effective and orally active soluble guanylate cyclase stimulator. It also enhances NO signaling and acts as a vasodilator. Target: Guanylate cyclase, Others. Smiles:...
| Keywords: | IW-1973 |
| Application: | Targets guanylate cyclase soluble subunit alpha [EC:4.6.1.2] (GUCY1A) |
| CAS | 1628730-49-3 |
| MW: | 534.36 D |
From 152.00€
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Ataciguat
Item number: TGM-T21607-100mg
Description: Ataciguat (HMR-1766) (HMR-1766) is a potent and specific soluble guanylate cyclase (sGC) activator. Target: Others, Guanylate cyclase. Smiles: N(S(=O)(=O)C1=CC=C(Cl)S1)C2=C(C(NC3=CC=C(S(=O)(=O)N4CCOCC4)C=C3)=O)C=C(Cl)C=C2. References: Martinelli AM, et, al. In Endothelial Cells, the Activation or...
| Keywords: | HMR-1766 |
| Application: | sGC, oxidized, heme-free, form, activator |
| CAS | 254877-67-3 |
| MW: | 576.49 D |
From 45.00€
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Lificiguat
Item number: TGM-T4381-100mg
Description: Lificiguat (YC-1) is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha). Target: HIF, Guanylate cyclase, Others. Smiles: OCc1ccc(o1)-c1nn(Cc2ccccc2)c2ccccc12. References: Martin E,etal.YC-1 activation of human...
| Keywords: | YC-1 |
| Application: | Soluble guanylyl cyclase (sGC) activator |
| CAS | 170632-47-0 |
| MW: | 304.34 D |
From 43.00€
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Nelociguat
Item number: TGM-T7201-100mg
Description: Nelociguat (BAY60-4552)(BAY60-4552) is a soluble guanylate cyclase stimulator (sGC stimulator). Soluble guanylate cyclase (sGC) is a key enzyme in the nitric oxide (NO) signalling pathway. Target: Guanylate cyclase. Smiles: COC(=O)Nc1c(N)nc(nc1N)-c1nn(Cc2ccccc2F)c2ncccc12. References: Oudot A ,...
| Keywords: | BAY60-4552 |
| Application: | Soluble guanylate cyclase and an active metabolite riociguat stimulator |
| CAS | 625115-52-8 |
| MW: | 408.39 D |
From 31.00€
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Riociguat
Item number: TGM-T6968-100mg
Description: Riociguat (BAY 632521) is a stimulator of guanylate cyclase which causes relaxation of vascular smooth muscle and is used to treat severe pulmonary arterial hypertension. Target: Guanylate cyclase. Smiles: COC(=O)N(C)c1c(N)nc(nc1N)-c1nn(Cc2ccccc2F)c2ncccc12. References: Schermuly RT, et al. Eur Respir...
| Keywords: | BAY 632521 |
| Application: | Targets guanylate cyclase soluble subunit alpha [EC:4.6.1.2] (GUCY1A) |
| CAS | 625115-55-1 |
| MW: | 422.42 D |
From 37.00€
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GUCY1A2 Protein, Human, Recombinant (His)
Item number: TGM-TMPH-01425-100ug
Description: GUCY1A2 Protein, Human, Recombinant (His) is expressed in E. coli.
| Keywords: | GUCY1A2, Guanylate cyclase soluble subunit alpha-2 |
| MW: | 27.8 kD |
From 281.00€
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Cinaciguat
Item number: TGM-T1984-100mg
Description: Cinaciguat (BAY 58-2667) (BAY 58-2667) is the first of a new class of soluble guanylate cyclase (sGC) activators in Clinicalal development for acute decompensated heart failure. Target: Guanylate cyclase. Smiles: O(CC1=CC=C(CCC2=CC=CC=C2)C=C1)C3=C(CCN(CC4=CC=C(C(O)=O)C=C4)CCCCC(O)=O)C=CC=C3. References:...
| Keywords: | BAY 58-2667 |
| Application: | Targets guanylate cyclase soluble subunit alpha [EC:4.6.1.2] (GUCY1A) |
| CAS | 329773-35-5 |
| MW: | 565.7 D |
From 42.00€
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Cinaciguat hydrochloride
Item number: TGM-T1984L-100mg
Description: Cinaciguat( BAY582667, BAY58-2667) is a soluble guanosine cyclase activator that can prevent cardiac dysfunction in rat models of type 1 diabetes. Target: Others. Smiles: Cl.OC(=O)CCCCN(CCc1ccccc1OCc1ccc(CCc2ccccc2)cc1)Cc1ccc(cc1)C(O)=O. References: Mátyás C, Németh BT, Oláh A, Hidi L, Birtalan E,...
| Keywords: | BAY 58-2667, BAY-58-2667, Cinaciguat HCl, BAY58-2667, BAY-582667, BAY 582667, BAY582667 |
| Application: | Soluble guanylate cyclase activator |
| CAS | 646995-35-9 |
| MW: | 602.17 D |
From 112.00€
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ODQ
Item number: TGM-T19777-100mg
Description: ODQ is an effective and selective soluble guanylyl cyclase (sGC) inhibitor. Target: Apoptosis, Guanylate cyclase, Others. Smiles: O=c1onc2cnc3ccccc3n12. References: Garthwaite J, Southam E, Boulton CL, Nielsen EB, Schmidt K, Mayer B. Potent and selective inhibition of nitric oxide-sensitive guanylyl...
| Application: | Soluble guanylyl cyclase inhibitor |
| CAS | 41443-28-1 |
| MW: | 187.15 D |
From 42.00€
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