351 products were found matching "K11987"!
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COX Fluorescent Inhibitor Screening Assay Kit
Item number: Cay700100-192
Cyclooxygenase (COX, also called Prostaglandin H Synthase or PGHS) is a bifunctional enzyme exhibiting both COX and peroxidase activities. The COX component converts arachidonic acid to a hydroperoxy endoperoxide (PGG2), and the peroxidase component reduces the endoperoxide to the corresponding alcohol (PGH2), the...
| Keywords: | Cyclooxygenase Fluorescent Inhibitor Screening Assay Kit |
| Application: | COX inhibitor screening |
895.00€
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COX-2 (human) Inhibitor Screening Assay Kit
Item number: Cay701080-96
The COX-2 (human) Inhibitor Screening Assay directly measures PGF2alpha by stannous chloride (SnCl2) reduction of COX-derived PGH2 produced in the COX reaction. The prostanoid product is quantified via ELISA using an antiserum specific to PGF2alpha. This assay includes recombinant human COX-2 and is an excellent...
| Keywords: | Cyclooxygenase 2 |
| Application: | Inhibitor screening |
584.00€
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Anti-COX-2 (Clone CX229)
Item number: Cay160112-1
Cyclooxygenase 2 (COX-2) is a bifunctional enzyme that exhibits both COX and peroxidase activities and catalyzes the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins. The COX component converts arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607) to the hydroperoxy endoperoxide...
| Keywords: | Cyclooxygenase 2, PGHS-2, Prostaglandin H Synthase 2 |
| Application: | IHC, WB |
| Host: | Mouse |
| Species reactivity: | human, ovine, monkey |
422.00€
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Meloxicam-d3
Item number: TGM-T11998-10mg
Description: Meloxicam D4 is deuterium labeled Meloxicam. Meloxicam is a non-steroidal antiinflammatory agent, inhibits COX activity,(Target:COX-1, IC50: 36.6 µM ,(Target:COX-2, IC50: 0.49 µM). Smiles: [2H]C([2H])([2H])N1C(C(=O)Nc2ncc(C)s2)=C(O)c2ccccc2S1(=O)=O. References: Lazer ES, et al. Effect of structural...
| Keywords: | Meloxicam D4 |
| Application: | COX-2 inhibitor, GC-MS, LC-MS, internal standard |
| CAS | 942047-63-4 |
| MW: | 354.42 D |
From 584.00€
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Rofecoxib
Item number: TGM-T1185-100mg
Description: Rofecoxib (MK 966) binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in an inhibition of the conversion of arachidonic acid to prostaglandins. Rofecoxib is a synthetic, nonsteroidal derivative of phenyl-furanone with anti-inflammatory, antipyretic and analgesic properties and...
| Keywords: | MK 966, MK-0966 |
| Application: | Targets prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1] (PTGS2, COX2) |
| CAS | 162011-90-7 |
| MW: | 314.36 D |
From 38.00€
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Nimesulide D5
Item number: TGM-T12227-1mg
Description: Nimesulide D5 is a deuterium labeled Nimesulide. Nimesulide is a selective inhibitor OF COX-2(IC50s of 70 nM-70 µM). Smiles: O(C1=C(NS(C)(=O)=O)C=CC(N(=O)=O)=C1)C2=C(C(=C(C(=C2[2H])[2H])[2H])[2H])[2H]. References: Vago T, et al. Effect of nimesulide action time dependence on selectivity towards...
| Application: | GC-MS, LC-MS internal standard, quantification, COX-2 inhibitor |
| CAS | 1330180-22-7 |
| MW: | 313.34 D |
162.00€
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DuP-697
Item number: TGM-T15181-100mg
Description: DuP-697 is an irreversible and specific inhibitor of COX-2 with IC50 values of 10 nM and 800 nM for human COX-2 and COX-1. DuP-697 shows antiproliferative activity with an IC50 of 42.8 nM. DuP-697 exhibits antiangiogenic, anti-inflammatory, antipyretic and apoptotic effects. Target: COX. Smiles:...
| Application: | COX-2 inhibitor |
| CAS | 88149-94-4 |
| MW: | 411.31 D |
From 72.00€
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GW-406381
Item number: TGM-T15449-100mg
Description: GW406381 is a highly selective inhibitor of cyclooxygenase-2 (COX-2). GW406381 also attenuates spontaneous ectopic discharge in the sural nerves of rats following chronic constriction injury. Target: COX. Smiles: CCOc1ccc(cc1)-c1nn2ncccc2c1-c1ccc(cc1)S(C)(=O)=O. References: Zhao FY, et al. GW406381, a...
| Application: | NSAID, COX-2 inhibitor |
| CAS | 221148-46-5 |
| MW: | 393.46 D |
From 739.00€
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Inotilone
Item number: TGM-T21808-1mg
Description: Inotilone is a major component of Inonotus linteus, a traditional Chinese medical herb and can be used for research of metastatic lung cancer cells. Target: Others. Smiles: C(=C/1\OC(C)=CC1=O)\C2=CC(O)=C(O)C=C2. References: Chao W, et al. Inotilone from Inonotus linteus suppresses lung cancer metastasis...
| Application: | COX-2 inhibitor |
| CAS | 906366-79-8 |
| MW: | 218.21 D |
From 48.00€
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Cimicoxib
Item number: TGM-T30937-100mg
Description: Cimicoxib (UR8880) is a potent and selective inhibitor of COX-2 with anti-inflammatory and analgesic activity. Target: COX. Smiles: ClC1=C(N(C=N1)C2=CC=C(S(N)(=O)=O)C=C2)C3=CC(F)=C(OC)C=C3. References: Kim TW, et al. Pharmacokinetic profiles of the novel COX-2 selective inhibitor cimicoxib in dogs. Vet...
| Keywords: | trade name: Cimalgex, UR8880, UR-8880 |
| Application: | COX-2 inhibitor |
| CAS | 265114-23-6 |
| MW: | 381.81 D |
From 39.00€
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NS-398
Item number: TGM-T3214-100mg
Description: NS-398 (N-(2-cyclohexyloxy-4-nitrophenyl)methane sulfonamide) is a COX-2 inhibitor wih anti-inflammatory activity. Target: COX. Smiles: CS(=O)(=O)Nc1cc(ccc1OC1CCCCC1)[N+]([O-])=O. References: Futaki N, et al. Prostaglandins. 1994, 47(1):55-9.
| Keywords: | N-(2-cyclohexyloxy-4-nitrophenyl)methane sulfonamide, NS398 |
| Application: | COX-2 inhibitor |
| CAS | 123653-11-2 |
| MW: | 314.36 D |
From 31.00€
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CAY10416
Item number: TGM-T36457-10mg
Description: Dual cyclooxygenase-2 (COX-2)/5-lipoxygenase (5-LO) inhibitors are potential therapeutic agents for inflammatory diseases and for prostate cancer. CAY10416 is a dual COX-2/5-LO inhibitor with IC50 values of 50 and 3 nM, respectively. The selectivity of CAY10416 for COX is greater than 200-fold for COX-2...
| Application: | COX-2 inhibitor, 5-LO inhibitor |
| CAS | 443919-96-8 |
| MW: | 536.61 D |
From 140.00€
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