346 products were found matching "K11987"!

Cyclooxygenase (COX, also called Prostaglandin H Synthase or PGHS) is a bifunctional enzyme exhibiting both COX and peroxidase activities. The COX component converts arachidonic acid to a hydroperoxy endoperoxide (PGG2), and the peroxidase component reduces the endoperoxide to the corresponding alcohol (PGH2), the...

The COX-2 (human) Inhibitor Screening Assay directly measures PGF2alpha by stannous chloride (SnCl2) reduction of COX-derived PGH2 produced in the COX reaction. The prostanoid product is quantified via ELISA using an antiserum specific to PGF2alpha. This assay includes recombinant human COX-2 and is an excellent...

Cyclooxygenase 2 (COX-2) is a bifunctional enzyme that exhibits both COX and peroxidase activities and catalyzes the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins. The COX component converts arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607) to the hydroperoxy endoperoxide...

Fenclofenac is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 7 and 4 µM for COX-1 and COX-2, respectively). It reduces paw volume in a rat model of adjuvant-induced polyarthritis when administered at doses of 3, 15, and 75 mg/kg and reverses yeast-induced motor impairments, a measure of...

Description: Inotilone is a major component of Inonotus linteus, a traditional Chinese medical herb and can be used for research of metastatic lung cancer cells. Target: Others. Smiles: C(=C/1\OC(C)=CC1=O)\C2=CC(O)=C(O)C=C2. References: Chao W, et al. Inotilone from Inonotus linteus suppresses lung cancer metastasis...

Description: Cimicoxib (UR8880) is a potent and selective inhibitor of COX-2 with anti-inflammatory and analgesic activity. Target: COX. Smiles: ClC1=C(N(C=N1)C2=CC=C(S(N)(=O)=O)C=C2)C3=CC(F)=C(OC)C=C3. References: Kim TW, et al. Pharmacokinetic profiles of the novel COX-2 selective inhibitor cimicoxib in dogs. Vet...

Description: NS-398 (N-(2-cyclohexyloxy-4-nitrophenyl)methane sulfonamide) is a COX-2 inhibitor wih anti-inflammatory activity. Target: COX. Smiles: CS(=O)(=O)Nc1cc(ccc1OC1CCCCC1)[N+]([O-])=O. References: Futaki N, et al. Prostaglandins. 1994, 47(1):55-9.

Description: Dual cyclooxygenase-2 (COX-2)/5-lipoxygenase (5-LO) inhibitors are potential therapeutic agents for inflammatory diseases and for prostate cancer. CAY10416 is a dual COX-2/5-LO inhibitor with IC50 values of 50 and 3 nM, respectively. The selectivity of CAY10416 for COX is greater than 200-fold for COX-2...

Description: Chrysin (5,7-Dihydroxyflavone) exhibits many biological activities and pharmacological effects, including antioxidant, anti-inflammatory, anticancer, and antiviral activities. Target: Antioxidant, Estrogen Receptor/ERR. Smiles: OC1=CC(O)=C2C(=O)C=C(OC2=C1)C1=CC=CC=C1. References: Mani R , Natesan V ....

Description: 5'-hydroxy Meloxicam is one of the metabolites of meloxicam (MEL). Target: Others. Smiles: CN1C(C(=O)Nc2ncc(CO)s2)=C(O)c2ccccc2S1(=O)=O , t:13,

Description: Diclofenac methyl ester is a hydrophobic prodrug form of diclofenac which is a non-steroidal anti-inflammatory drug (NSAID). Diclofenac methyl ester is more soluble than diclofenac acid in isopropylmyristate but with higher toxicity. Target: Others. Smiles: COC(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl. References:...

Description: [10]-Shogaol (10-Shogaol) is an extract from ginger displaying antioxidant activity. It also may contain hypolipidemic and insulin-sensitizing effects. Target: COX, Antioxidant. Smiles: CCCCCCCCC\C=C\C(=O)CCc1ccc(O)c(OC)c1. References: Min BR, et al. Effects of Tissue Culture and Mycorrhiza...