45 products were found matching "K11843"!

Description: B-AP15 (NSC-687852)(NSC-687852) is a selective inhibitor of the deubiquitinating enzymes Usp14 and UCHL5 of the 26S proteasome. It blocks the deubiquitinating activity of the 26S proteasome. Target: DUB, Apoptosis. Smiles: C(=C\1/C(=O)\C(=C\C2=CC=C(N(=O)=O)C=C2)\CN(C(C=C)=O)C1)\C3=CC=C(N(=O)=O)C=C3....

Description: IU1-47 is an effective and specific USP14 inhibitor (IC50: 0.6 µM). IU1-47 causes tau elimination in cultured neurons. IU1-47 inhibits IsoT/USP5 (IC50: 20 µM). Target: DUB. Smiles: Cc1cc(C(=O)CN2CCCCC2)c(C)n1-c1ccc(Cl)cc1. References: Boselli M, et al. An inhibitor of the proteasomal deubiquitinating...

Description: VLX1570 is a competitive inhibitor of proteasome DUB activity, with an IC50 ranging from 4.2 µM to 8.6 µM, and exhibits potent inhibition of USP14. Target: DUB. Smiles: [O-][N+](=O)c1cc(\C=C2\CCN(C\C(=C\c3ccc(F)c(c3)[N+]([O-])=O)C2=O)C(=O)C=C)ccc1F. References: Wang X et al. Synthesis and evaluation of...

Description: IU1(IC50=4.7 µ M), a reversible, specific human USP14 proteasome inhibitor, can penetrate the cell. Target: DUB, Autophagy. Smiles: Cc1c(ccn1-c1ccc(F)cc1)C(=O)CN1CCCC1. References: Byung-Hoon L, et al. Nature, 2010, 467(7312), 179-184.

Isotype: Rabbit IgG. Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Affinity-chromatography. Target Name: USP14. Antigen Species: Human

Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 1-494aa. Protein Length: Full Length. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: MPLYSVTVKW GKEKFEGVEL NTDEPPMVFK AQLFALTGVQ PARQKVMVKG GTLKDDDWGN IKIKNGMTLL MMGSADALPE EPSAKTVFVE DMTEEQLASA MELPCGLTNL GNTCYMNATV QCIRSVPELK...

Polybiquitinylation designates proteins for proteasomal degradation. USP14 is one of several deubiquitinating enzymes (DUBs) responsible for shortening proteasome-bound ubiquitin chains, which is known to antagonize the degradation of ubiquitin-protein conjugates. IU1 is a reversible, small molecule inhibitor of...

Protein function: Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell....

Protein ubiquitination is a dynamic process that can be reversed by deubiquitinating enzymes (DUBs) that remove ubiquitin from proteins, sparing them from degradation by the proteasome. The DUBs have been divided into two subgroups: ubiquitin-specific proteases (USPs) and ubiquitin-specific COOH-terminal hydrolases...

Protein function: Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell....

Human USP14 (Ubiquitin-Specific Protease 14) or TGT (tRNA-guanine transglycosylase), GenBank Accession No. NM_005151, amino-acids 2-494(end) with an N-terminal FLAG-tag, MW=57 kDa, expressed in a baculovirus-infected Sf9 cell expression system.

Proteasome-associated deubiquitinases (DUBs) release ubiquitin from proteasome-targeted ubiquitinated proteins, regenerating free ubiquitin. b-AP15 is an inhibitor of ubiquitin-specific-processing protease 14 (USP14) and ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5), two proteasome-associated DUBs. It...