24 products were found matching "K11839"!

DUB-IN-3 is an inhibitor of ubiquitin-specific protease 8 (USP8, IC50 = 0.56 µM). It is selective for USP8 over USP7 (IC50 = >100 µM). DUB-IN-3 is also an inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) papain-like protease (PLpro) when Z-LRGG-AMC is used as a substrate (IC50 = 12.5 µM) but...

USP8-IN-1 is an inhibitor of ubiquitin-specific protease 8 (USP8, IC50 = 2.6 µM). It is selective for USP8 over USP7 (IC50 = >20 µM). USP8-IN-1 inhibits colony formation by H1975 non-small cell lung cancer (NSCLC) cells (IC50 = 30.8 µM).Formal Name:...

USP8-IN-2 is an inhibitor of ubiquitin-specific protease 8 (USP8, IC50 = 6 µM).Formal Name: N-(5-chloro-2-methoxyphenyl)-N'-[1-[6-(trifluoromethyl)-2-pyridinyl]-4-piperidinyl]-thiourea. CAS Number: 2477651-11-7. Synonyms: Ubiquitin-specific Protease 8-IN-2, Ubiquitin-specific Protease 8 Inhibitor 2, USP Inhibitor 2....

USP8-IN-3 is an inhibitor of ubiquitin-specific protease 8 (USP8, IC50 = 4 µM). It inhibits the growth of H1975 non-small cell lung cancer (NSCLC) and GH3 rat pituitary cells (GI50s = 6.01 and 37.03 µM).Formal Name: N-(4-nitrophenyl)-N'-[1-[6-(trifluoromethyl)-2-pyridinyl]-4-piperidinyl]-thiourea. CAS Number:...

DUB-IN-1 is an inhibitor of ubiquitin-specific protease 8 (USP8, IC50 = 0.85 µM). It is selective for USP8 over USP7 (IC50 = >100 µM). It inhibits the proliferation of LN-229, U87MG, and T98G glioblastoma cells when used at concentrations ranging from 200 to 800 nM. DUB-IN-1 (500 and 800 nM) reduces the migration...

Description: Ubiquitin Isopeptidase Inhibitor I, G5 is a caspase-independent inducer of cell necrosis that induces cell death via the death receptor pathway (IC50 of 1.76 and 1.6 µM in E1A and E1A/C9DN cells, respectively). Target: Apoptosis. Smiles:...

Protein function: Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell...

Protein function: Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell...

Human USP8 (Ubiquitin-Specific Protease 8) or UBPY, GenBank Accession No. NM_005154, amino-acids 2-1118(end) with an N-terminal FLAG-tag, MW=128 kDa, expressed in a baculovirus-infected Sf9 cell expression system.

This gene encodes a protein that belongs to the ubiquitin-specific processing protease family of proteins. The encoded protein is thought to regulate the morphology of the endosome by ubiquitination of proteins on this organelle and is involved in cargo sorting and membrane trafficking at the early endosome stage....

Protein function: Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell...

Protein function: Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell...