54 products were found matching "K11437"!

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Anti-PRMT6
Anti-PRMT6

Item number: ABS-KC-6070.100

Protein function: Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA (PubMed:17898714, PubMed:18077460, PubMed:18079182, PubMed:19405910, PubMed:30420520). Preferentially...
Keywords: Anti-Protein arginine N-methyltransferase 6, Anti-Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein...
Host: Mouse
Species reactivity: human
From 232.00€ *
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EPZ020411
EPZ020411

Item number: TGM-T4314-10mg

Description: EPZ020411 is a specific and effective inhibitor of PRMT6 (IC50=10 nM). Target: Histone Methyltransferase. Smiles: CNCCN(C)Cc1c[nH]nc1-c1ccc(O[C@H]2C[C@@H](C2)OCCC2CCOCC2)cc1. References: Mitchell LH, et al. Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First...
Keywords: EPZ020411 2HCl
Application: Potent, selective PRMT6 inhibitor
CAS 1700663-41-7
MW: 442.6 D
From 136.00€ *
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MS023
MS023

Item number: TGM-T6900-100mg

Description: MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 values of 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively. Target: Histone Methyltransferase. Smiles: CC(C)Oc1ccc(cc1)-c1c[nH]cc1CN(C)CCN. References: Eram MS, et al. ACS Chem Biol....
Application: Type I PRMT inhibitor
CAS 1831110-54-3
MW: 287.4 D
From 34.00€ *
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SGC6870
SGC6870

Item number: TGM-T69580-25mg

Description: SGC6870 is a novel potent, selective, and cell-active inhibitor of PRMT6 with IC50 of 77 ± 6 nM, being selective over all other PRMTs and 23 methyltransferases. Target: Others. Smiles: C(=O)(N1[C@@H](C=2C(NC(=O)C1)=CC=C(C)C2)C3=CC(C)=CC(C)=C3)C=4SC(Br)=CC4
Application: PRMT6 inhibitor
CAS 2561471-27-8
MW: 469.39 D
From 547.00€ *
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GSK3368715 hydrochloride
GSK3368715 hydrochloride

Item number: TGM-T84982-10mg

Description: GSK3368715, a first-in-class, orally active, potent, and selective SAM-noncompetitive inhibitor of Type I Protein Arginine Methyltransferases (PRMTs), exhibits anti-tumor efficacy across multiple cancer models and alters exon usage with IC50 values in the lower nM range. It synergizes with GSK3326595...
Keywords: GSK715 hydrochloride
Application: Type I PRMT inhibitor
CAS 2227587-25-7
MW: 403 D
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PRMT6 Protein, Human, Recombinant (His & Flag)
PRMT6 Protein, Human, Recombinant (His & Flag)

Item number: TGM-TMPY-01383-50ug

Description: Protein arginine N-methyltransferase 6, also known as Histone-arginine N-methyltransferase PRMT6, PRMT6, and HRMT1L6, is a member of the protein arginine N-methyltransferase family and PRMT6 subfamily. PRMT6 is highly expressed in kidney and testes. PRMT6 is known to catalyze the generation of...
Keywords: protein arginine methyltransferase 6, HRMT1L6
MW: 44.4 kD
599.00€ *
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PRMT6, active human recombinant protein, N-terminal His-tag
PRMT6, active human recombinant protein, N-terminal His-tag

Item number: BPS-51049

Human PRMT6 (GenBank Accession No. NM_018137), amino-acids 2-375(end), with N-terminal His-tag, MW=43 kDa, expressed in E. coli. Assay conditions: 50 µl reaction mix (20 mM phosphate buffer pH 7.4, 20 µM S-adenosylmethionine, and 1-5 ng methyl-transferase PRMT6) is added to microwells coated with histone substrate....
Keywords: PRMT6, HRMT1L6, Protein arginine N-methyltransferase 6, Histone-arginine N-methyltransferase PRMT6, Heterogeneous nuclear...
Application: Enzyme kinetics, inhibitor screening, selectivity profiling
Expressed in: E.coli
Origin: human
MW: 43 kD
498.00€ *
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Anti-PRMT6
Anti-PRMT6

Item number: A300-928A

Protein function: Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays...
Keywords: Anti-PRMT6, Anti-HRMT1L6, Anti-Protein arginine N-methyltransferase 6, Anti-Histone-arginine N-methyltransferase PRMT6,...
Application: WB, IP
Host: Rabbit
Species reactivity: human
From 178.00€ *
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Anti-PRMT6
Anti-PRMT6

Item number: A300-929A

Protein function: Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays...
Keywords: Anti-PRMT6, Anti-HRMT1L6, Anti-Protein arginine N-methyltransferase 6, Anti-Histone-arginine N-methyltransferase PRMT6,...
Application: WB, IP, IHC
Host: Rabbit
Species reactivity: human
From 178.00€ *
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GSK3368715 (hydrochloride)
GSK3368715 (hydrochloride)

Item number: Cay34886-1

GSK3368715 is an inhibitor of type I protein arginine methyltransferases (PRMTs, IC50s = 3.1, 162, 38, 4.7, and 39 nM for PRMT1, 3, 4, 6, and 8, respectively). It is selective for type I PRMTs over PRMT5, 7, and 9 (IC50s = >20,408, >40,000, and >15,000 nM, respectively), as well as 20 additional methyltransferases...
Keywords: N1-[[3-[4,4-bis(ethoxymethyl)cyclohexyl]-1H-pyrazol-4-yl]methyl]-N1,N2-dimethyl-1,2-ethanediamine, monohydrochloride
Application: Type I PRMT inhibitor
CAS 2227587-25-7
MW: 403 D
From 106.00€ *
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EPZ020411
EPZ020411

Item number: Cay19160-1

EPZ020411 is an inhibitor of protein arginine methyltranferase 6 (PRMT6, IC50 = 10 nM) that less potently targets PRMT1 and PRMT8 (IC50s = 119 and 223 nM, respectively). It dose-dependently decreases methylation of the PRMT6 substrate H3R2 in A375 cells transiently expressing PRMT6 (IC50 = 0.637 µM). EPZ020411 shows...
Keywords: N1,N2-dimethyl-N1-[[3-[4-[[trans-3-[2-(tetrahydro-2H-pyran-4-yl)ethoxy]cyclobutyl]oxy]phenyl]-1H-pyrazol-4-yl]methyl]-1,2-...
Application: Potent, selective PRMT6 inhibitor
CAS 1700663-41-7
MW: 442.6 D
From 65.00€ *
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MS049 (hydrochloride)
MS049 (hydrochloride)

Item number: Cay18348-1

MS049 is a potent and selective inhibitor of PRMT4 (IC50 = 34 nM) and PRMT6 (IC50 = 43 nM). It is less active against additional type I PRMTs (IC50s = >130, >220, and 1.6 µM for PRMT1, PRMT3, and PRMT8, respectively) and displays no inhibition against type II or type III PRMTs nor any additional methyltransferases...
Keywords: N-methyl-4-(phenylmethoxy)-1-piperidineethanamine, dihydrochloride
Application: PRMT4 inhibitor, PRMT6 inhibitor
CAS 2095432-59-8
MW: 321.3 D
From 61.00€ *
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