123 products were found matching "K11430"!
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EPZ005687
Item number: TGM-T1905-100mg
Description: EPZ005687, a potent and selective inhibitor of EZH2. Target: Histone Methyltransferase. Smiles: Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)-c2ccc(CN3CCOCC3)cc2)c(=O)[nH]1. References: Knutson SK, et al. Nat Chem Biol, 2012, 8(11), 890-896.
| Application: | Lysine methyltranferase EZH2 inhibitor |
| CAS | 1396772-26-1 |
| MW: | 539.67 D |
From 53.00€
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GSK503
Item number: TGM-T1775-100mg
Description: GSK-503, a potent EZH2 inhibitor, has potential antitumor activity. Target: Histone Methyltransferase. Smiles: CC(C)n1cc(C)c2c(cc(cc12)-c1ccc(nc1)N1CCN(C)CC1)C(=O)NCc1c(C)cc(C)[nH]c1=O. References: Béguelin W, et al. Cancer Cell. 2013, 23(5), 677-692
| Application: | EZH2 inhibitor |
| CAS | 1346572-63-1 |
| MW: | 526.67 D |
From 34.00€
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EI1
Item number: TGM-T6484-100mg
Description: EI1 (Ezh2 inhibitor) is a potent and selective EZH2 inhibitor with IC50 of 15 nM and 13 nM for EZH2 (WT) and EZH2 (Y641F), respectively. Target: Apoptosis, Histone Methyltransferase. Smiles: CCC(CC)n1ccc2c(cc(cc12)C#N)C(=O)NCc1c(C)cc(C)[nH]c1=O. References: Qi W, et al. Proc Natl Acad Sci U S A. 2012,...
| Keywords: | KB-145943, Ezh2 inhibitor |
| Application: | EZH2 inhibitor |
| CAS | 1418308-27-6 |
| MW: | 390.48 D |
From 38.00€
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3-deazaneplanocin A HCl
Item number: TGM-T6360-100mg
Description: 3-deazaneplanocin A HCl is both an S-adenosyl-l-homocysteine hydrolase inhibitor and an enhancer of zeste homolog 2(EZH2) inhibitor. Target: Others, Histone Methyltransferase. Smiles: Cl.Nc1nccc2n(cnc12)C1C=C(CO)C(O)C1O. References: Glazer RI, et al. Biochem Pharmacol, 1986, 35(24), 4523-4527.
| Application: | Apoptosis inducer, trimethylation inhibitor |
| CAS | 120964-45-6 |
| MW: | 298.73 D |
From 89.00€
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CPI-169 racemate
Item number: TGM-T6809-100mg
Description: CPI-169 racemate (CPI 169) is a potent, and selective EZH2 inhibitor with IC50 of 0.24 nM, 0.51 nM, and 6.1 nM for EZH2 WT, EZH2 Y641N, and EZH1, respectively. Target: Epigenetic Reader Domain, Histone Methyltransferase. Smiles: CCS(=O)(=O)N1CCC(CC1)C(C)n1c(C)c(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c2ccccc12....
| Keywords: | CPI-169, CPI 169, CPI169 |
| Application: | EZH2 inhibitor |
| CAS | 1450655-76-1 |
| MW: | 528.66 D |
From 53.00€
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CPI-360
Item number: TGM-T6810-100mg
Description: CPI-360 is a small molecule EZH2 inhibitor (IC50: 0.002 µM, EC50: 0.080 µM) that shows antitumor activity in an EZH200-dependent tumor xenograft model. Target: Histone Methyltransferase, Apoptosis. Smiles: [C@H](C)(N1C=2C(C(C(NCC3=C(OC)C=C(C)NC3=O)=O)=C1C)=CC=CC2)C4CCOCC4. References: Vatolin S, et al....
| Keywords: | CPI360, Synonym 2, Synonym 2, CPI 360 |
| Application: | Selective EZH2 inhibitor |
| CAS | 1802175-06-9 |
| MW: | 437.53 D |
From 76.00€
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GSK343
Item number: TGM-T6059-100mg
Description: GSK343, a specific and effective EZH2 inhibitor (IC50=4 nM), exhibits 60 fold specificity activity against EZH1, and >1000 fold specificity activity against other histone methyltransferases. Target: Histone Methyltransferase, Autophagy. Smiles:...
| Application: | Cell-permeable EZH2 inhibitor |
| CAS | 1346704-33-3 |
| MW: | 541.69 D |
From 54.00€
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MS1943
Item number: TGM-T13780-100mg
Description: MS1943 is a orally bioavailable EZH2 selective degrader(IC50 of 120 nM). Target: Histone Methyltransferase, Apoptosis. Smiles: CC(C)n1ncc2c(cc(cc12)-c1ccc(nc1)N1CCN(CCNC(=O)CC23CC4CC(CC(C4)C2)C3)CC1)C(=O)NCc1c(C)cc(C)[nH]c1=O. References: Ma A, et al. Discovery of a first-in-class EZH2 selective...
| Application: | EZH2 degradation driving PROTAC |
| CAS | 2225938-17-8 |
| MW: | 718.93 D |
From 55.00€
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GSK126
Item number: TGM-T2079-100mg
Description: GSK126 (GSK2816126A) is a excellently specific EZH2 methyltransferase inhibitor ( IC50=9.9 nM). Target: Histone Methyltransferase. Smiles: CC[C@H](C)n1cc(C)c2c(cc(cc12)-c1ccc(nc1)N1CCNCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O. References: Ott HM, et al. A687V EZH2 is a driver of histone H3 lysine 27 (H3K27)...
| Keywords: | GSK2816126A, EZH2 inhibitor |
| Application: | Selective EZH2 methyltransferase inhibitor |
| CAS | 1346574-57-9 |
| MW: | 526.67 D |
From 39.00€
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UNC1999
Item number: TGM-T3057-100mg
Description: UNC1999 is a orally bioavailable, effective and specific inhibitor of EZH2 (IC50=2 nM) and EZH1 (IC50=45). Target: Autophagy, Histone Methyltransferase. Smiles: CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(ncc12)C(C)C)-c1ccc(nc1)N1CCN(CC1)C(C)C. References: Konze KD, et al. ACS Chem. Biol. 2013, 8 (6),...
| Application: | Cell-permeable EZH2 inhibitor |
| CAS | 1431612-23-5 |
| MW: | 569.74 D |
From 34.00€
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ZLD1039
Item number: TGM-T29231-10mg
Description: ZLD1039 is a potent, orally bioavailable EZH2 (Enhancer of Zeste Homolog 2) inhibitor with high selectivity. It demonstrates strong, concentration-dependent inhibition of both wild-type and mutant (Y641F and A677G) PRC2 (Polycomb Repressive Complex 2) enzymatic activities, exhibiting IC50 values of 5.6,...
| Keywords: | ZLD 1039, ZLD-1039 |
| Application: | EZH2 inhibitor |
| CAS | 1826865-46-6 |
| MW: | 612.8 D |
From 33.00€
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JQEZ5
Item number: TGM-T7305-100mg
Description: JQEZ5 is an inhibitor of EZH2 lysine methyltransferase (IC50 = 11.1 nM). Target: Histone Methyltransferase. Smiles: CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(nc2n(ncc12)C(C)C)-c1ccc(nc1)N1CCN(C)CC1. References: Xie H , Peng C , Huang J , et al. Chronic Myelogenous Leukemia- Initiating Cells Require Polycomb...
| Application: | EZH2 lysine methyltransferase inhibitor |
| CAS | 1913252-04-6 |
| MW: | 542.68 D |
From 36.00€
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