46 products were found matching "K11409"!

Protein function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses...

Description: TMP195 (TFMO 2) is a selective class IIa histone deacetylase (HDAC) inhibitor. Target: HDAC. Smiles: CC(C)(CNC(=O)c1cccc(c1)-c1noc(n1)C(F)(F)F)c1coc(n1)-c1ccccc1. References: Lobera M., et al. Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group. Nat Chem Biol. 2013...

Description: HDAC9 Protein, Human, Recombinant (His) is expressed in E. coli.

Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...

Host Species: Rabbit. Isotype: IgG. Buffer: Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: >95%, Protein G purified. Target Name: HDAC9. Antigen Species: Human

Host Species: Rabbit. Isotype: IgG. Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by...

Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 814-1011aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: ILIVDLDVHH GNGTQQAFYA DPSILYISLH RYDEGNFFPG SGAPNEVGTG LGEGYNINIA WTGGLDPPMG DVEYLEAFRT IVKPVAKEFD PDMVLVSAGF DALEGHTPPL GGYKVTAKCF GHLTKQLMTL ADGRVVLALE...

Active human HDAC9 , GenBank Accession No. NM_178423, amino acids 604- 1066 with C-terminal His tag, MW= 50.7 kDa, expressed in baculovirus expression system.

TMP-195 is an inhibitor of class IIa histone deacetylases (HDACs, Kis = 59, 60, 26, and 15 nM for HDAC4, 5, 7, and 9, respectively). It is selective for class IIa HDACs over class I and class IIb HDACs (Kis = 10-43 µM for HDAC1-3, 6, 9, and 10-11). TMP-195 blocks accumulation of chemoattractant chemokine ligand 2...

The Fluorogenic HDAC9 Assay Kit is a complete assay system designed to measure histone deacetylases 9 (HDAC9) activity for screening and profiling applications. It comes in a convenient 96-well format, with all the reagents necessary for fluorescent HDAC activity measurements. In addition, the kit includes purified...

While class I HDACs are localized predominantly within the nucleus, class II HDACs shuttle into and out of the nucleus in response to intracellular signaling. Class IIa HDACs, which includes HDAC4, 5, 7, and 9, commonly act as corepressors and play diverse roles in cell biology. MC 1568 is a selective inhibitor of...

Protein function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses...