56 products were found matching "K11219"!

Organism: Homo sapiens (Human). Source: Baculovirus. Expression Region: 589-875aa. Protein Length: Partial. Tag Info: N-terminal 10xHis-tagged. Target Protein Sequence: ITQLSHLGQG TRTNVYEGRL RVEGSGDPEE GKMDDEDPLV PGRDRGQELR VVLKVLDPSH HDIALAFYET ASLMSQVSHT HLAFVHGVCV RGPENIMVTE YVEHGPLDVW LRRERGHVPM AWKMVVAQQL...

Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 556-871aa. Protein Length: Partial. Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged. Target Protein Sequence: GETSNLIIMR GARASPRTLN LSQLSFHRVD QKEITQLSHL GQGTRTNVYE GRLRVEGSGD PEEGKMDDED PLVPGRDRGQ ELRVVLKVLD PSHHDIALAF YETASLMSQV...

Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 556-871aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: GETSNLIIMR GARASPRTLN LSQLSFHRVD QKEITQLSHL GQGTRTNVYE GRLRVEGSGD PEEGKMDDED PLVPGRDRGQ ELRVVLKVLD PSHHDIALAF YETASLMSQV SHTHLAFVHG VCVRGPENIM VTEYVEHGPL...

Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 589-875aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: ITQLSHLGQG TRTNVYEGRL RVEGSGDPEE GKMDDEDPLV PGRDRGQELR VVLKVLDPSH HDIALAFYET ASLMSQVSHT HLAFVHGVCV RGPENIMVTE YVEHGPLDVW LRRERGHVPM AWKMVVAQQL ASALSYLENK...

Zasocitinib is an inhibitor of tyrosine kinase 2 (TYK2). It selectively binds to the TYK2 Janus homology (JH2) domain (Kd = 0.0038 nM) over the JAK1 and JAK2 JH2 domains (Kds = 4,975 and 23,000 nM, respectively). Zasocitinib inhibits the production of chemokine (C-X-C motif) ligand 10 (CXCL10) induced by IFN-alpha...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human Tyk2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human Tyk2. Next,...

Janus kinase (JAK) is a family of intracellular, nonreceptor tyrosine kinases that play an important role in cytokine-mediated signaling. This family includes four protein kinases, Jak1, Jak2, Jak3 and Tyk2. Various studies have suggested that regulation of Jak activity should be a promising approach to combat...

Human Tyrosine Kinase 2 (TYK2), also known as JTK1, IMD35, and Non-Receptor Tyrosine-Protein Kinase TYK2, Genbank Accession No. NM_003331, a.a. 575-869 with N-terminal FLAG-tag, expressed in Sf9 cells via a baculovirus expression system. MW = 34 kDa.

BMS 986165 is an allosteric inhibitor of tyrosine kinase 2 (TYK2, IC50 = 0.2 nM for the recombinant TYK2 pseudokinase domain). It is selective for TYK2 over a panel of 249 protein and lipid kinases at 1 µM but does inhibit the JAK1 pseudokinase domain and bone morphogenetic protein receptor type II (BMPR2, IC50s = 1...

Cerdulatinib is a dual inhibitor of spleen tyrosine kinase (Syk) and Janus kinases (JAK, IC50s = 32, 12, 6, 8, and 0.5 nM for Syk, JAK1, JAK2, JAK3, and TYK2, respectively) and also exhibits nanomolar inhibition of other kinases. Syk is involved in the B cell receptor (BCR) pathway, and cerdulatinib inhibits...

Peficitinib is an inhibitor of JAK (IC50s = 3.9, 5, and 0.71 nM for JAK1-3, respectively). It is 14-fold selective for JAK1 and JAK3 over JAK2 in erythropoietin-induced leukemia cell proliferation assays. Peficitinib inhibits IL-2-induced proliferation of rat splenocytes (IC50 = 10 nM) and phosphorylation of STAT5...

Active recombinant human Tyk2 (Tyrosine Kinase 2, alsoknown as JTK1), GenBank Accession No. NM_003331, a.a. 871-1187(end), with N-terminal His-tag, MW=38 kDa, expressed in a Baculovirus-infected Sf9 cell expression system.