103 products were found matching "K11217"!
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AZD 4604
Item number: Cay39890-10
AZD 4604 is a JAK1 inhibitor (IC50 = 0.54 nM). It is selective for JAK1 over JAK2 and JAK3 (IC50s = 686 and >10,000 nM, respectively), as well as tyrosine kinase 2 (TYK2, IC50 = 657 nM). AZD 4604 inhibits IL-4- or IL-13-induced phosphorylation of STAT6 in U937 cells (IC50s = 24 and 34 nM, respectively). In vivo, AZD...
| Keywords: | Londamocitinib,... |
| Application: | JAK1 inhibitor |
| CAS | 2241039-81-4 |
| MW: | 599.7 D |
From 35.00€
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Anti-JAK1
Item number: ABS-KC-4322.100
Protein function: Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:7615558). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529) as well as interleukin (IL)-10 receptor (PubMed:12133952). [The UniProt Consortium]
| Keywords: | Anti-Tyrosine-protein kinase JAK1, Anti-Janus kinase 1, Anti-JAK-1, JAK1 Antibody |
| Application: | IHC |
| Host: | Mouse |
| Species reactivity: | human, rat, mouse |
From 206.00€
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Anti-JAK1
Item number: ABS-KC-6293.100
Protein function: Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:7615558). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529) as well as interleukin (IL)-10 receptor (PubMed:12133952). [The UniProt Consortium]
| Keywords: | Anti-Tyrosine-protein kinase JAK1, Anti-Janus kinase 1, Anti-JAK-1, JAK1 Antibody |
| Host: | Mouse |
| Species reactivity: | human, rat |
From 232.00€
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Anti-JAK1
Item number: ABS-KC-6294.100
Protein function: Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:7615558). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529) as well as interleukin (IL)-10 receptor (PubMed:12133952). [The UniProt Consortium]
| Keywords: | Anti-Tyrosine-protein kinase JAK1, Anti-Janus kinase 1, Anti-JAK-1, JAK1 Antibody |
| Host: | Mouse |
| Species reactivity: | human, rat |
From 232.00€
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Anti-JAK1
Item number: E-AN006070L.100
This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription)...
| Keywords: | Anti-JAK1, Anti-JAK1A, Anti-JAK-1, Anti-Janus kinase 1, Anti-Tyrosine-protein kinase JAK1, JAK1 Polyclonal Antibody |
| Application: | IHC |
| Host: | Rabbit |
| Species reactivity: | human |
From 109.00€
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JAK1 JH2 Domain (human, recombinant, aa 561-852)
Item number: Cay42271-1
JAK1 is a non-receptor tyrosine kinase that has roles in immune signaling. It is composed of N-terminal FERM and SH2 domains, a regulatory pseudokinase domain (JH2), and a C-terminal kinase domain. It is widely expressed and associates with class I and class II cytokine receptors at the plasma membrane. Activation...
| Keywords: | JAK1, JAK1A, JAK-1, JAK-1, Janus kinase 1, Janus kinase 1, Tyrosine-protein kinase JAK1, Tyrosine-protein kinase JAK1 |
| Application: | Active enzyme |
| Expressed in: | Insect cells |
| Origin: | human |
From 505.00€
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Povorcitinib phosphate
Item number: TGM-T39113L-100mg
Description: Povorcitinib phosphate is a selective JAK1 inhibitor and can be used in studies about the treatment of cutaneous lupus erythematosus and Lichen planus. Target: JAK. Smiles: O=P(O)(O)O.N#CCC1(N2C=C(C(C(C)=NN3)=C3C)C=N2)CN(C(C=C(F)C(C(N[C@@H](C)C(F)(F)F)=O)=C4)=C4F)C1. References: Paul Smith, et al. Use...
| Application: | Targets Janus kinase 1 [EC:2.7.10.2] (JAK1) |
| CAS | 1637677-33-8 |
| MW: | 605.45 D |
From 60.00€
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Itacitinib
Item number: TGM-T3998-100mg
Description: Itacitinib (INCB039110) is an orally bioavailable Janus-associated kinase 1 (JAK1) inhibitor with potential antineoplastic activity. Target: JAK. Smiles: Fc1c(ccnc1C(F)(F)F)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12. References: Bissonnette R, et al. A randomized, double-blind,...
| Keywords: | INCB039110, INCB39110 |
| Application: | Targets Janus kinase 1 [EC:2.7.10.2] (JAK1) |
| CAS | 1334298-90-6 |
| MW: | 553.51 D |
From 45.00€
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Filgotinib HCl hydrate
Item number: TGM-T70472-100mg
Description: Filgotinib hydrochloride hydrate is a potent and selective JAK1 inhibitor under investigation for the treatment of rheumatoid arthritis (RA) and Crohn's disease. Target: Others
| Application: | Targets Janus kinase 1 [EC:2.7.10.2] (JAK1) |
| CAS | 1540859-07-1 |
| MW: | 516.01 D |
From 1,520.00€
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JAK1/2/3 Inhibitor 1
Item number: TGM-T77504-100mg
Description: JAK1/2/3 Inhibitor 1 is a potent protein kinase inhibitor.JAK1/2/3 Inhibitor 1 has antitumor activity that inhibits the growth of a variety of cancer cell lines. It inhibits the growth of cancer cells by binding to the cancer cell backbone and inhibiting the production of new proteins. Target: PKA....
| Application: | JAK1/2/3 inhibitor |
| CAS | 16234-14-3 |
| MW: | 205.06 D |
From 49.00€
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Upadacitinib
Item number: TGM-T7503-100mg
Description: Upadacitinib (ABT-494) (ABT-494) is a selective Janus kinase (JAK) 1 inhibitor, which is being studied for the treatment of several autoimmune disorders in the IC50 of 43 nM. Target: JAK. Smiles: CC[C@@H]1CN(C[C@@H]1c1cnc2cnc3[nH]ccc3n12)C(=O)NCC(F)(F)F. References: Nakayamada S, et al. Recent Progress...
| Keywords: | ABT-494 |
| Application: | Targets Janus kinase 1 [EC:2.7.10.2] (JAK1) |
| CAS | 1310726-60-3 |
| MW: | 380.37 D |
From 40.00€
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Upadacitinib tartrate
Item number: TGM-T7503L-100mg
Description: Upadacitinib is a potent and selective JAK inhibitor. Upadacitinib is approximately 74 fold selective for Jak1 over Jak2 in cellular assays dependent on specific, relevant cytokines. Upadacitinib demonstrates efficacy in rat arthritis models. Target: Others. Smiles:...
| Keywords: | ABT-494, ABT494, ABT 494 |
| Application: | Targets Janus kinase 1 [EC:2.7.10.2] (JAK1) |
| CAS | 1607431-21-9 |
| MW: | 602.521 D |
From 1,971.00€
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