103 products were found matching "K11217"!
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AZD 4604
Item number: Cay39890-10
AZD 4604 is a JAK1 inhibitor (IC50 = 0.54 nM). It is selective for JAK1 over JAK2 and JAK3 (IC50s = 686 and >10,000 nM, respectively), as well as tyrosine kinase 2 (TYK2, IC50 = 657 nM). AZD 4604 inhibits IL-4- or IL-13-induced phosphorylation of STAT6 in U937 cells (IC50s = 24 and 34 nM, respectively). In vivo, AZD...
| Keywords: | Londamocitinib,... |
| Application: | JAK1 inhibitor |
| CAS | 2241039-81-4 |
| MW: | 599.7 D |
From 35.00€
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Anti-JAK1
Item number: ABS-KC-4322.100
Protein function: Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:7615558). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529) as well as interleukin (IL)-10 receptor (PubMed:12133952). [The UniProt Consortium]
| Keywords: | Anti-Tyrosine-protein kinase JAK1, Anti-Janus kinase 1, Anti-JAK-1, JAK1 Antibody |
| Application: | IHC |
| Host: | Mouse |
| Species reactivity: | human, rat, mouse |
From 206.00€
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Anti-JAK1
Item number: ABS-KC-6293.100
Protein function: Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:7615558). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529) as well as interleukin (IL)-10 receptor (PubMed:12133952). [The UniProt Consortium]
| Keywords: | Anti-Tyrosine-protein kinase JAK1, Anti-Janus kinase 1, Anti-JAK-1, JAK1 Antibody |
| Host: | Mouse |
| Species reactivity: | human, rat |
From 232.00€
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Anti-JAK1
Item number: ABS-KC-6294.100
Protein function: Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:7615558). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529) as well as interleukin (IL)-10 receptor (PubMed:12133952). [The UniProt Consortium]
| Keywords: | Anti-Tyrosine-protein kinase JAK1, Anti-Janus kinase 1, Anti-JAK-1, JAK1 Antibody |
| Host: | Mouse |
| Species reactivity: | human, rat |
From 232.00€
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Anti-JAK1
Item number: E-AN006070L.100
This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription)...
| Keywords: | Anti-JAK1, Anti-JAK1A, Anti-JAK-1, Anti-Janus kinase 1, Anti-Tyrosine-protein kinase JAK1, JAK1 Polyclonal Antibody |
| Application: | IHC |
| Host: | Rabbit |
| Species reactivity: | human |
From 109.00€
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JAK1 JH2 Domain (human, recombinant, aa 561-852)
Item number: Cay42271-1
JAK1 is a non-receptor tyrosine kinase that has roles in immune signaling. It is composed of N-terminal FERM and SH2 domains, a regulatory pseudokinase domain (JH2), and a C-terminal kinase domain. It is widely expressed and associates with class I and class II cytokine receptors at the plasma membrane. Activation...
| Keywords: | JAK1, JAK1A, JAK-1, JAK-1, Janus kinase 1, Janus kinase 1, Tyrosine-protein kinase JAK1, Tyrosine-protein kinase JAK1 |
| Application: | Active enzyme |
| Expressed in: | Insect cells |
| Origin: | human |
From 505.00€
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Brepocitinib P-Tosylate
Item number: TGM-T12427-100mg
Description: Brepocitinib P-Tosylate (PF-06700841 P-Tosylate) is a potent dual inhibitor of Janus kinase 1 (JAK1) and TYK2 (IC50s of 17 nM and 23 nM, respectively). Target: JAK. Smiles: Cc1ccc(cc1)S(O)(=O)=O.Cn1cc(Nc2nccc(n2)N2CC3CCC(C2)N3C(=O)[C@@H]2CC2(F)F)cn1. References: Fensome A, et al. Dual Inhibition of TYK2...
| Keywords: | PF-06700841 P-Tosylate |
| Application: | Targets Janus kinase 1 [EC:2.7.10.2] (JAK1) |
| CAS | 2140301-96-6 |
| MW: | 561.6 D |
From 31.00€
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Povorcitinib phosphate
Item number: TGM-T39113L-100mg
Description: Povorcitinib phosphate is a selective JAK1 inhibitor and can be used in studies about the treatment of cutaneous lupus erythematosus and Lichen planus. Target: JAK. Smiles: O=P(O)(O)O.N#CCC1(N2C=C(C(C(C)=NN3)=C3C)C=N2)CN(C(C=C(F)C(C(N[C@@H](C)C(F)(F)F)=O)=C4)=C4F)C1. References: Paul Smith, et al. Use...
| Application: | Targets Janus kinase 1 [EC:2.7.10.2] (JAK1) |
| CAS | 1637677-33-8 |
| MW: | 605.45 D |
From 60.00€
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Itacitinib
Item number: TGM-T3998-100mg
Description: Itacitinib (INCB039110) is an orally bioavailable Janus-associated kinase 1 (JAK1) inhibitor with potential antineoplastic activity. Target: JAK. Smiles: Fc1c(ccnc1C(F)(F)F)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12. References: Bissonnette R, et al. A randomized, double-blind,...
| Keywords: | INCB039110, INCB39110 |
| Application: | Targets Janus kinase 1 [EC:2.7.10.2] (JAK1) |
| CAS | 1334298-90-6 |
| MW: | 553.51 D |
From 45.00€
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Filgotinib HCl hydrate
Item number: TGM-T70472-100mg
Description: Filgotinib hydrochloride hydrate is a potent and selective JAK1 inhibitor under investigation for the treatment of rheumatoid arthritis (RA) and Crohn's disease. Target: Others
| Application: | Targets Janus kinase 1 [EC:2.7.10.2] (JAK1) |
| CAS | 1540859-07-1 |
| MW: | 516.01 D |
From 1,520.00€
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JAK1/2/3 Inhibitor 1
Item number: TGM-T77504-100mg
Description: JAK1/2/3 Inhibitor 1 is a potent protein kinase inhibitor.JAK1/2/3 Inhibitor 1 has antitumor activity that inhibits the growth of a variety of cancer cell lines. It inhibits the growth of cancer cells by binding to the cancer cell backbone and inhibiting the production of new proteins. Target: PKA....
| Application: | JAK1/2/3 inhibitor |
| CAS | 16234-14-3 |
| MW: | 205.06 D |
From 49.00€
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Upadacitinib
Item number: TGM-T7503-100mg
Description: Upadacitinib (ABT-494) (ABT-494) is a selective Janus kinase (JAK) 1 inhibitor, which is being studied for the treatment of several autoimmune disorders in the IC50 of 43 nM. Target: JAK. Smiles: CC[C@@H]1CN(C[C@@H]1c1cnc2cnc3[nH]ccc3n12)C(=O)NCC(F)(F)F. References: Nakayamada S, et al. Recent Progress...
| Keywords: | ABT-494 |
| Application: | Targets Janus kinase 1 [EC:2.7.10.2] (JAK1) |
| CAS | 1310726-60-3 |
| MW: | 380.37 D |
From 40.00€
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