33 products were found matching "K11204"!

L-Buthionine-(S,R)-sulfoximine is an irreversible inhibitor of gamma-glutamylcysteine synthetase (Ki = 25 µM). It inhibits the proliferation of ZAZ and M14 melanoma cells, as well as A2780 ovarian and MCF-7 breast cancer cells (IC50s = 4.9, 18, 8.5, and 26.5 µM, respectively). L-Buthionine-(S,R)-sulfoximine (100µM)...

Description: L-Buthionine-(S,R)-sulfoximine, a cell-permeable and irreversible inhibitor of gamma-glutamylcysteine synthetase (Ki <100 µM), induces oxidative stress in cells by depleting GSH. Target: Ferroptosis, Others. Smiles: CCCCS(=N)(=O)CC[C@H](N)C(O)=O. References: Marengo B, et al. Mechanisms of BSO...

Description: DL-Buthionine-(S,R)-sulfoximine (Butionine sulfoximine) is an inhibitor of gamma-glutamylcysteine synthetase used for the treatment of solid tumors. Target: Ferroptosis, Others. Smiles: CCCCS(=N)(=O)CCC(N)C(O)=O. References: Arrick, B. A . Inhibition of glutathione synthesis as a chemotherapeutic...

Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse GCLC. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse GCLC. Next,...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat GCLC. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat GCLC. Next,...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human GCLC. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human GCLC. Next,...

D,L-Buthionine-(S,R)-sulfoximine is an inhibitor of gamma-glutamylcysteine synthetase that induces 100% inhibition at a concentration of 10 µM in an enzyme assay. It is selective for gamma-glutamylcysteine synthetase, lacking activity at glutamine synthetase at concentrations up to 500 µM....

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Glutamate--cysteine ligase catalytic subunit, is an enzyme that in humans is encoded by the GCLC gene. Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of...

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Glutamate-cysteine ligase catalytic subunit is an enzyme that in humans is encoded by the GCLC gene. Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two...

In 1X PBS, pH 7.4, with 0.09% sodium azide. Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit,...