163 products were found matching "K10798"!
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Olaparib
Item number: Cay10621-5
Many of the products generated by alkylating agents on DNA can be efficiently repaired by normal base excision repair (BER). Some poly(ADP-ribose) polymerases (PARPs) assist in the repair of single-strand DNA nicks, an important step in BER. Olaparib is a potent inhibitor of PARP1 and PARP2 (IC50 = 5 and 1 nM,...
| Keywords: | AZD 2281, Ku-0059436, 4-[[3-[[4-(cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2H)-phthalazinone |
| Application: | PARP1 / PARP2 inhibitor |
| CAS | 763113-22-0 |
| MW: | 434.5 D |
From 66.00€
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BGP-15
Item number: TGM-T3649-100mg
Description: BGP-15 (BGP-15 2HCl) is a PARP inhibitor with protecting effect after ischemia-reperfusion injury. Target: PARP. Smiles: Cl.Cl.N\C(=N/OCC(O)CN1CCCCC1)c1cccnc1. References: Racz I, et al. Biochem Pharmacol. 2002, 63(6):1099-111.
| Keywords: | BGP-15 2HCl, BGP15 |
| Application: | PARP inhibitor, insulin sensitizer |
| CAS | 66611-37-8 |
| MW: | 351.27 D |
From 31.00€
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Olaparib
Item number: TGM-T3015-100mg
Description: Olaparib (KU0059436) is a small molecule inhibitor of PARP1/PARP2 (IC50=5/1 nM), with weak inhibitory activity against PARP tankyrase-1 (IC50=1.5 µM), and is selective and orally active. Olaparib exhibits autophagy and mitochondrial autophagy activation activity. Target: PARP, Mitophagy, Autophagy....
| Keywords: | KU0059436, AZD2281 |
| Application: | Targets poly [ADP-ribose] polymerase 1 [EC:2.4.2.30] (PARP1) |
| CAS | 763113-22-0 |
| MW: | 434.46 D |
From 32.00€
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TIQ-A
Item number: TGM-T50098-100mg
Description: TIQ-A is a PARP1 inhibitor which involved in DNA single-strand break repair via the base excision repair pathway. PARP1 is triggered by DNA damage and its excessive activation has been proposed as a causative factor in many pathological conditions including ischemia and reperfusion injury,...
| Application: | PARP1 inhibitor |
| CAS | 420849-22-5 |
| MW: | 201.24 D |
From 75.00€
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Rucaparib
Item number: TGM-T4463-100mg
Description: Rucaparib (PF-01367338) is a PARP protein inhibitor (PARP-1 Ki=1.4 nM) and hexose hexose-6-phosphate dehydrogenase (H6PD) inhibitor with oral activity. Rucaparib exhibits antitumor activity, with activity against desmoplasia-resistant prostate cancer (CRPC). Target: PARP. Smiles:...
| Keywords: | AG014699, AG-14447, PF-01367338 |
| Application: | Targets poly [ADP-ribose] polymerase 1 [EC:2.4.2.30] (PARP1) |
| CAS | 283173-50-2 |
| MW: | 323.36 D |
From 41.00€
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E7449
Item number: TGM-T4471-100mg
Description: E7449 (UNII-9X5A2QIA7C) is a potent PARP1 and PARP2 inhibitor and also inhibits TNKS1 and TNKS2, with IC50s of 2.0, 1.0, ~50 and ~50 nM for PARP1, PARP2, TNKS1 and TNKS2, respectively, using 32P-NAD+ as substrate. Target: PARP, Others. Smiles: O=c1[nH][nH]c2nc(CN3Cc4ccccc4C3)nc3cccc1c23. References:...
| Keywords: | UNII-9X5A2QIA7C, Stenoparib |
| Application: | PARP1 / PARP2 inhibitor |
| CAS | 1140964-99-3 |
| MW: | 317.34 D |
From 38.00€
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NMS-P118
Item number: TGM-T4472-100mg
Description: NMS-P118 is a potent, selective and orally available Inhibitor of PARP-1 for cancer therapy. Target: PARP. Smiles: NC(=O)c1cc(F)cc2CN(C3CCN(CC3)C3CCC(F)(F)CC3)C(=O)c12. References: Papeo G, et al. Discovery of...
| Application: | PARP-1 inhibitor |
| CAS | 1262417-51-5 |
| MW: | 395.42 D |
From 37.00€
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UPF 1069
Item number: TGM-T6181-100mg
Description: UPF 1069 is a specific PARP2 inhibitor ( IC50: 0.3 µM). It is ~27-fold selective against PARP1. Target: PARP. Smiles: O=C(COc1cccc2c1cc[nH]c2=O)c1ccccc1. References: Moroni F, et al. Br J Pharmacol, 2009, 157(5), 854-862.
| Application: | PARP inhibitor |
| CAS | 1048371-03-4 |
| MW: | 279.29 D |
From 32.00€
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Niraparib tosylate
Item number: TGM-T6892-100mg
Description: Niraparib tosylate (MK-4827 (tosylate))(with IC50 of 3.8 nM/2.1 nM) is a selective PARP1/PARP2 inhibitor. Target: Apoptosis, PARP. Smiles: Cc1ccc(cc1)S(O)(=O)=O.NC(=O)c1cccc2cn(nc12)-c1ccc(cc1)[C@@H]1CCCNC1. References: Wang L, et al. Invest New Drugs. 2012, 30(6):2113-20.
| Keywords: | MK 4827 tosylate, MK-4827 (tosylate), Niraparib (MK-4827) tosylate |
| Application: | Antineoplastic |
| CAS | 1038915-73-9 |
| MW: | 492.59 D |
From 38.00€
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1,5-Isoquinolinediol
Item number: TGM-T7042-100mg
Description: 1, 5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1, IC50: 0.39 µM). The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis. 1, 5-Isoquinolinediol has been used to study the role of PARP1 in both DNA repair and oxidant...
| Application: | PARP-1 inhibitor |
| CAS | 5154-02-9 |
| MW: | 161.16 D |
From 32.00€
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6(5H)-Phenanthridinone
Item number: TGM-T72017-10mg
Description: 6(5H)-Phenanthridinone is an inhibitor of poly(ADP-ribose) polymerase 1 (PARP1) and PARP2. It decreases radiation-induced PARP activity and proliferation of RDM4 murine lymphoma cells. 6(5H)-Phenanthridinone reduces NF-kappaB-induced transcription of the genes encoding TNF-alpha, IL-2, and IFN-gamma in...
| Application: | PARP1/2 inhibitor |
| CAS | 1015-89-0 |
| MW: | 195.22 D |
From 86.00€
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3-Methoxybenzamide
Item number: TGM-T7439-100mg
Description: 3-Methoxybenzamide (3-MBA) is a competitive inhibitor of poly(ADP-ribose) synthetase. Target: PARP, Antibacterial, Transferase. Smiles: COC1=CC=CC(=C1)C(N)=O. References: Ohashi Y , Chijiiwa Y , Suzuki K , et al. The Lethal Effect of a Benzamide Derivative, 3-Methoxybenzamide, Can Be Suppressed by...
| Keywords: | 3-MBA |
| Application: | PARP inhibitor |
| CAS | 5813-86-5 |
| MW: | 151.16 D |
From 31.00€
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