163 products were found matching "K10798"!
No results were found for the filter!
PARP/PI3K-IN-1
Item number: TGM-T12365-100mg
Description: PARP/PI3K-IN-1 is a novel dual poly (ADP-ribose) polymerase (PARP) and phosphatidylinositol 3-kinase (PI3K) dual inhibitor with anticancer, antitumour and antiproliferative activities for the study of breast, pancreatic and lung cancers. Target: PI3K, PARP. Smiles:...
| Application: | PARP / PI3K dual inhibitor |
| CAS | 2337386-47-5 |
| MW: | 660.62 D |
From 96.00€
*
Rucaparib monocamsylate
Item number: TGM-T16807-100mg
Description: Rucaparib monocamsylate (Rucaparib Camsylate) is a PARP inhibitor (PARP1,Ki of 1.4 nM). Rucaparib Camsylate also displays binding affinity to eight other PARP domains. Target: PARP. Smiles: [H][C@@]12CC[C@@](CS(O)(=O)=O)(C(=O)C1)C2(C)C.CNCc1ccc(cc1)-c1[nH]c2cc(F)cc3C(=O)NCCc1c23. References: Thomas HD,...
| Keywords: | Rucaparib Camsylate |
| Application: | Targets poly [ADP-ribose] polymerase 1 [EC:2.4.2.30] (PARP1) |
| CAS | 1859053-21-6 |
| MW: | 555.66 D |
From 54.00€
*
Talazoparib tosylate
Item number: TGM-T16979-2mg
Description: Talazoparib tosylate is a novel and potent PARP1/2 (n IC50: 0.57 nM for PARP1). Target: PARP. Smiles: Cc1ccc(cc1)S(O)(=O)=O.Cn1ncnc1[C@@H]1[C@H](Nc2cc(F)cc3c2c1n[nH]c3=O)c1ccc(F)cc1. References: Shen Y, et al. BMN 673, a novel and highly potent PARP1/2 inhibitor for the treatment of human cancers with...
| Keywords: | BMN 673ts |
| Application: | Targets poly [ADP-ribose] polymerase 1 [EC:2.4.2.30] (PARP1) |
| CAS | 1373431-65-2 |
| MW: | 552.55 D |
44.00€
*
BGP-15
Item number: TGM-T3649-100mg
Description: BGP-15 (BGP-15 2HCl) is a PARP inhibitor with protecting effect after ischemia-reperfusion injury. Target: PARP. Smiles: Cl.Cl.N\C(=N/OCC(O)CN1CCCCC1)c1cccnc1. References: Racz I, et al. Biochem Pharmacol. 2002, 63(6):1099-111.
| Keywords: | BGP-15 2HCl, BGP15 |
| Application: | PARP inhibitor, insulin sensitizer |
| CAS | 66611-37-8 |
| MW: | 351.27 D |
From 31.00€
*
Olaparib
Item number: TGM-T3015-100mg
Description: Olaparib (KU0059436) is a small molecule inhibitor of PARP1/PARP2 (IC50=5/1 nM), with weak inhibitory activity against PARP tankyrase-1 (IC50=1.5 µM), and is selective and orally active. Olaparib exhibits autophagy and mitochondrial autophagy activation activity. Target: PARP, Mitophagy, Autophagy....
| Keywords: | KU0059436, AZD2281 |
| Application: | Targets poly [ADP-ribose] polymerase 1 [EC:2.4.2.30] (PARP1) |
| CAS | 763113-22-0 |
| MW: | 434.46 D |
From 32.00€
*
TIQ-A
Item number: TGM-T50098-100mg
Description: TIQ-A is a PARP1 inhibitor which involved in DNA single-strand break repair via the base excision repair pathway. PARP1 is triggered by DNA damage and its excessive activation has been proposed as a causative factor in many pathological conditions including ischemia and reperfusion injury,...
| Application: | PARP1 inhibitor |
| CAS | 420849-22-5 |
| MW: | 201.24 D |
From 75.00€
*
Rucaparib
Item number: TGM-T4463-100mg
Description: Rucaparib (PF-01367338) is a PARP protein inhibitor (PARP-1 Ki=1.4 nM) and hexose hexose-6-phosphate dehydrogenase (H6PD) inhibitor with oral activity. Rucaparib exhibits antitumor activity, with activity against desmoplasia-resistant prostate cancer (CRPC). Target: PARP. Smiles:...
| Keywords: | AG014699, AG-14447, PF-01367338 |
| Application: | Targets poly [ADP-ribose] polymerase 1 [EC:2.4.2.30] (PARP1) |
| CAS | 283173-50-2 |
| MW: | 323.36 D |
From 41.00€
*
E7449
Item number: TGM-T4471-100mg
Description: E7449 (UNII-9X5A2QIA7C) is a potent PARP1 and PARP2 inhibitor and also inhibits TNKS1 and TNKS2, with IC50s of 2.0, 1.0, ~50 and ~50 nM for PARP1, PARP2, TNKS1 and TNKS2, respectively, using 32P-NAD+ as substrate. Target: PARP, Others. Smiles: O=c1[nH][nH]c2nc(CN3Cc4ccccc4C3)nc3cccc1c23. References:...
| Keywords: | UNII-9X5A2QIA7C, Stenoparib |
| Application: | PARP1 / PARP2 inhibitor |
| CAS | 1140964-99-3 |
| MW: | 317.34 D |
From 38.00€
*
NMS-P118
Item number: TGM-T4472-100mg
Description: NMS-P118 is a potent, selective and orally available Inhibitor of PARP-1 for cancer therapy. Target: PARP. Smiles: NC(=O)c1cc(F)cc2CN(C3CCN(CC3)C3CCC(F)(F)CC3)C(=O)c12. References: Papeo G, et al. Discovery of...
| Application: | PARP-1 inhibitor |
| CAS | 1262417-51-5 |
| MW: | 395.42 D |
From 37.00€
*
UPF 1069
Item number: TGM-T6181-100mg
Description: UPF 1069 is a specific PARP2 inhibitor ( IC50: 0.3 µM). It is ~27-fold selective against PARP1. Target: PARP. Smiles: O=C(COc1cccc2c1cc[nH]c2=O)c1ccccc1. References: Moroni F, et al. Br J Pharmacol, 2009, 157(5), 854-862.
| Application: | PARP inhibitor |
| CAS | 1048371-03-4 |
| MW: | 279.29 D |
From 32.00€
*
Niraparib tosylate
Item number: TGM-T6892-100mg
Description: Niraparib tosylate (MK-4827 (tosylate))(with IC50 of 3.8 nM/2.1 nM) is a selective PARP1/PARP2 inhibitor. Target: Apoptosis, PARP. Smiles: Cc1ccc(cc1)S(O)(=O)=O.NC(=O)c1cccc2cn(nc12)-c1ccc(cc1)[C@@H]1CCCNC1. References: Wang L, et al. Invest New Drugs. 2012, 30(6):2113-20.
| Keywords: | MK 4827 tosylate, MK-4827 (tosylate), Niraparib (MK-4827) tosylate |
| Application: | Antineoplastic |
| CAS | 1038915-73-9 |
| MW: | 492.59 D |
From 38.00€
*
1,5-Isoquinolinediol
Item number: TGM-T7042-100mg
Description: 1, 5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1, IC50: 0.39 µM). The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis. 1, 5-Isoquinolinediol has been used to study the role of PARP1 in both DNA repair and oxidant...
| Application: | PARP-1 inhibitor |
| CAS | 5154-02-9 |
| MW: | 161.16 D |
From 32.00€
*