55 products were found matching "K09095"!

ZG-2033 is an agonist of hypoxia-inducible factor 2alpha (HIF-2alpha). It induces HIF-2alpha transcriptional activity in a reporter assay using 786-O cells expressing HIF-2alpha (EC50 = 0.49 µM). ZG-2033 (10 or 50 µM), in combination with the inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) and...

Description: M1001 is a HIF-2alpha agonist. Target: HIF/HIF Prolyl-Hydroxylase, HIF. Smiles: O=S1(=O)N=C(Nc2ccccc2N2CCCC2)c2ccccc12. References: Bidirectional Modulation of HIF-2 Activity through Chemical Ligands[C]// 0.

Description: PT-2385 is a selective inhibitor of HIF-2alpha with a dissociation constant (Kd) of less than 50 nM (Kd<50 nM). Target: HIF, HIF/HIF Prolyl-Hydroxylase. Smiles: CS(=O)(=O)c1ccc(Oc2cc(F)cc(c2)C#N)c2CC(F)(F)[C@@H](O)c12. References: Eli Wallace, Ph.D. PT2385: HIF-2alpha Antagonist for the Treatment of...

Description: TC-S 7009 is a potent and selective HIF-2alpha inhibitor (Kd: 81 nM) with significantly higher affinity for HIF-2alpha than HIF-1alpha (Kd >> 5µM). TC-S 7009 disrupts HIF-2alpha heterodimerization, reduces HIF-2alpha target gene expression, and diminishes DNA binding activity. Target: HIF. Smiles:...

Description: Belzutifan (MK-6482) is a potential treatment for clear cell renal cell carcinoma (ccRCC). Belzutifan is an orally active and selective HIF-2alpha inhibitor (IC50: 9 nM). Belzutifan , as a second-generation HIF-2alpha inhibitor, increases potency and improves pharmacokinetic profile. Target: HIF....

PT2385 is an inhibitor of hypoxia-inducible factor-2alpha (HIF-2alpha, IC50 = 12 nM). It inhibits HIF-2alpha-induced production of Vegfa mRNA and reduces tumor volume in a 786-O renal cell carcinoma mouse xenograft model when administered at a dose of 10 mg/kg. PT2385 (20 mg/kg) also inhibits the transcription of...

Protein function: Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT, heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems...

Protein function: Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT, heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems...

Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...

Host Species: Rabbit. Isotype: IgG. Buffer: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antibodies were produced by immunizing rabbits...

Protein function: Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of...

HIF-2alpha antagonist 2 is an inhibitor of hypoxia-inducible factor-2alpha (HIF-2alpha) PAS-B domain heterodimerization. It binds to the HIF-2alpha PAS-B domain (Kd = 81 nM) to inhibit heterodimerization with the aryl hydrocarbon receptor nuclear translocator (ARNT) PAS-B domain in cell-free assays when used at...