53 products were found matching "K08849"!
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Necrosulfonamide
Item number: TGM-T6904-100mg
Description: (E)-Necrosulfonamide ((E)-Necrosulfonamide) is an inhibitor of necroptosis. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during necrosis. Prevents MLKL-RIP1-RIP3 necrosome complex from interacting with downstream...
| Keywords: | (E)-Necrosulfonamide |
| Application: | Necroptosis inhibitor, MLKL inhibitor |
| CAS | 1360614-48-7 |
| MW: | 461.47 D |
From 52.00€
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MLKL Protein, Human, Recombinant (E. coli, His)
Item number: TGM-TMPH-01694-100ug
Description: Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Does not have protein kinase activity. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by...
| Keywords: | MLKL, Mixed lineage kinase domain-like protein |
| MW: | 58.5 kD |
From 278.00€
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MLKL Protein (Sumo Tag) (recombinant human)
Item number: E-PDEH100508.100
Sequence: Met1-leu180. Fusion tag: N-Sumo Endotoxin: < 1.0 EU per µg of the protein as determined by the LAL method Observed Molecular Mass: 37 kDa. Protein function: Protein function: Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process (PubMed:22265413, PubMed:22265414,...
| Keywords: | hMLKL, Mixed lineage kinase domain-like protein, Recombinant Human MLKL Protein(Sumo Tag) |
| Expressed in: | E.coli |
| Origin: | human |
From 248.00€
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Mixed lineage kinase domain-like protein (Mlkl), mouse,...
Item number: CSB-YP861529MO.1
Organism: Mus musculus (Mouse). Source: Yeast. Expression Region: 1-472aa. Protein Length: Full Length. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: MDKLGQIIKL GQLIYEQCEK MKYCRKQCQR LGNRVHGLLQ PLQRLQAQGK KNLPDDITAA LGRFDEVLKE ANQQIEKFSK KSHIWKFVSV GNDKILFHEV NEKLRDVWEE LLLLLQVYHW NTVSDVSQPA SWQQEDRQDA...
| Keywords: | Mixed lineage kinase domain-like protein, Recombinant Mouse Mixed lineage kinase domain-like protein (Mlkl) |
| Application: | Activity not tested |
| Expressed in: | Yeast |
| Origin: | mouse |
| MW: | 56.3 kD |
From 283.00€
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Mixed lineage kinase domain-like protein (MLKL), human,...
Item number: CSB-EP850851HU.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 1-471aa. Protein Length: Full Length. Tag Info: N-terminal 6xHis-SUMO-tagged. Target Protein Sequence: MENLKHIITL GQVIHKRCEE MKYCKKQCRR LGHRVLGLIK PLEMLQDQGK RSVPSEKLTT AMNRFKAALE EANGEIEKFS NRSNICRFLT ASQDKILFKD VNRKLSDVWK ELSLLLQVEQ RMPVSPISQG...
| Keywords: | hMLKL, Mixed lineage kinase domain-like protein, Recombinant Human Mixed lineage kinase domain-like protein (MLKL) |
| Application: | Activity not tested |
| Expressed in: | E.coli |
| Origin: | human |
| MW: | 70.5 kD |
From 213.00€
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Mixed lineage kinase domain-like protein (MLKL), human,...
Item number: CSB-EP850851HUa0.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 1-471aa. Protein Length: Full Length. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: MENLKHIITL GQVIHKRCEE MKYCKKQCRR LGHRVLGLIK PLEMLQDQGK RSVPSEKLTT AMNRFKAALE EANGEIEKFS NRSNICRFLT ASQDKILFKD VNRKLSDVWK ELSLLLQVEQ RMPVSPISQG...
| Keywords: | hMLKL, Mixed lineage kinase domain-like protein, Recombinant Human Mixed lineage kinase domain-like protein (MLKL) |
| Application: | Activity not tested |
| Expressed in: | E.coli |
| Origin: | human |
| MW: | 58.5 kD |
From 283.00€
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Mixed lineage kinase domain-like protein (MLKL), human,...
Item number: CSB-EP850851HUb2.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 1-471aa. Protein Length: Full Length. Tag Info: N-terminal 10xHis-SUMO-tagged. Target Protein Sequence: MENLKHIITL GQVIHKRCEE MKYCKKQCRR LGHRVLGLIK PLEMLQDQGK RSVPSEKLTT AMNRFKAALE EANGEIEKFS NRSNICRFLT ASQDKILFKD VNRKLSDVWK ELSLLLQVEQ RMPVSPISQG...
| Keywords: | hMLKL, Mixed lineage kinase domain-like protein, Recombinant Human Mixed lineage kinase domain-like protein (MLKL) |
| Application: | Activity not tested |
| Expressed in: | E.coli |
| Origin: | human |
| MW: | 69.1 kD |
From 213.00€
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Anti-MLKL
Item number: CSB-PA003250.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Keywords: | Anti-hMLKL, Anti-Mixed lineage kinase domain-like protein, 9130019I15Rik antibody, FLJ34389 antibody, hMLKL antibody,... |
| Application: | ELISA, WB |
| Host: | Rabbit |
| Species reactivity: | human |
From 106.00€
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Necrosulfonamide
Item number: Cay20844-5
Necrosulfonamide is a small molecule that inhibits necroptosis by blocking mixed lineage kinase domain-like protein (MLKL), a key substrate of receptor-interacting serine-threonine kinase 3 (RIPK3). Necrosulfonamide has been shown to prevent the MLKL-RIPK1-RIPK3 necrosome complex from interacting with downstream...
| Keywords: | (2E)-N-[4-[[(3-methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide |
| Application: | Necroptosis inhibitor, MLKL inhibitor |
| CAS | 1360614-48-7 |
| MW: | 461.5 D |
From 53.00€
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Necrosulfonamide
Item number: AG-CR1-3705-M005
Off-white to yellow solid. Soluble in DMSO (20mg/ml) or DMF (20mg/ml). Insoluble in water. Chemical. CAS: 1360614-48-7. Formula: C18H15N5O6S2. MW: 461.5. Inhibitor of necroptosis, by blocking mixed lineage kinase domain-like protein (MLKL), a key substrate of receptor-interacting serine-threonine kinase 3 (RIP3)....
| Keywords: | NSA, (2E)-N-[4-[[(3-methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide |
| Application: | Necroptosis inhibitor, MLKL inhibitor |
| CAS | 1360614-48-7 |
| MW: | 461,5 D |
From 55.00€
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Human MLKL (Mixed Lineage Kinase Domain Like Protein)...
Item number: ELK-ELK7715.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human MLKL. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human MLKL. Next,...
| Keywords: | hMLKL, Mixed lineage kinase domain-like protein |
| Application: | ELISA |
| Species reactivity: | human |
From 365.00€
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Phytic acid . sodium salt . hydrate
Item number: AG-CN2-0528-M025
Isolated from Oryza sativa. Direct activator of necroptosis inducer MLKL (mixed lineage kinase domain-like). Necroptosis is an inflammatory form of programmed cell death executed through plasma membrane rupture by the pseudokinase mixed lineage kinase domain-like (MLKL). Addition of IP6 promotes membrane...
| Keywords: | D-myo-Inositol-1,2,3,4,5,6-hexaphosphate sodium salt hydrate, IP6 |
| Application: | Iron (Fe) chelator, Anticancer, antiinflammatory, antidiabetic, neuroprotective antioxidant |
| MW: | 660 D |
From 44.00€
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