97 products were found matching "K08822"!
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SB 216763
Item number: TGM-T3077-100mg
Description: SB 216763 (SB216763) is an effective and specific GSK-3alpha/beta inhibitor (IC50: 34.3 nM). Target: GSK-3, Autophagy. Smiles: O=C1C(C=2C=3C(N(C)C2)=CC=CC3)=C(C(=O)N1)C4=C(Cl)C=C(Cl)C=C4. References: Coghlan MP, et al. Chem Biol, 2000, 7(10), 793-803.
| Keywords: | SB216763 |
| Application: | Potent selective cell permeable ATP-competitive inhibitor of GSK3 inhibitor |
| CAS | 280744-09-4 |
| MW: | 371.22 D |
From 34.00€
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CHIR 98024
Item number: TGM-T3074-100mg
Description: CHIR 98024 is a potent GSK-3alpha/beta inhibitor with IC50 of 0.65 nM/0.58 nM in cell-free assays, with the ability to distinguish GSK-3 from its closest homologs Cdc2 and ERK2. Target: S6 Kinase, GSK-3. Smiles: Nc1nc(NCCNc2ncc(-c3ncc[nH]3)c(n2)-c2ccc(Cl)cc2Cl)ccc1[N+]([O-])=O. References: Ring DB,et...
| Keywords: | CHIR98014 |
| Application: | GSK3 inhibitor |
| CAS | 556813-39-9 |
| MW: | 486.31 D |
From 38.00€
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GSK-3 inhibitor 4
Item number: TGM-T77341-100mg
Description: GSK-3 inhibitor 4 is an orally active and brain-permeable compound that acts as a triple inhibitor of GSK-3, CDK2, and CDK5, with IC50 values of 0.56 nM (GSK-3beta), 0.45 nM (GSK-3alpha), 0.47 µM (CDK2), and 0.68 µM (CDK5). It effectively reduces Tau protein levels and can be used in the study of...
| Application: | GSK-3 inhibitor |
| CAS | 2227279-83-4 |
| MW: | 403.38 D |
From 348.00€
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GSK-3 Inhibitor XIII
Item number: TGM-T78578-100mg
Description: GSK-3 Inhibitor XIII, an ATP-competitive GSK-3 inhibitor (Ki: 24 nM), can be used to study diabetes and obesity. Target: GSK-3. Smiles: N=1NC(=CC1NC=2N=C(N=C3C=CC=CC32)C=4C=CC=CC4)C. References: Eduardo Cruz Moraes, et al. Kinase inhibitor profile for human nek1, nek6, and nek7 and analysis of the...
| Application: | GSK-3 inhibitor |
| CAS | 404828-14-4 |
| MW: | 301.35 D |
From 122.00€
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AZD1080
Item number: TGM-T1741-100mg
Description: AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor. Target: GSK-3. Smiles: Oc1[nH]c2ccc(cc2c1-c1ccc(CN2CCOCC2)cn1)C#N. References: Georgievska B, et al. J Neurochem, 2013, 125(3), 446-456.
| Application: | Brain permeable GSK3alpha/beta inhibitor |
| CAS | 612487-72-6 |
| MW: | 334.37 D |
From 37.00€
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LY2090314
Item number: TGM-T1755-100mg
Description: LY2090314, an effective GSK-3alpha/beta inhibitor (IC50: 1.5 nM/0.9 nM), may improve the efficacy of platinum-based chemotherapy regimens. LY2090314 has been used in trials studying the treatment of Leukemia, Advanced Cancer, and Pancreatic Cancer. Target: GSK-3. Smiles:...
| Application: | GSK-3alpha / GSK-3beta inhibitor |
| CAS | 603288-22-8 |
| MW: | 512.53 D |
From 42.00€
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CHIR-98014
Item number: TGM-T2608-100mg
Description: CHIR-98014 (CT98014) is a selective GSK3 inhibitor, potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Target: Src, GSK-3, FGFR, S6 Kinase. Smiles: ClC1=C(C=2C(=CN=C(NCCNC=3N=C(N)C(N(=O)=O)=CC3)N2)N4C=CN=C4)C=CC(Cl)=C1. References: Ring DB,et al. Diabetes. 2003,...
| Keywords: | CHIR98014, CHIR 98014, CT98014 |
| Application: | GSK3alpha / GSK3beta inhibitor |
| CAS | 252935-94-7 |
| MW: | 486.31 D |
From 67.00€
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SB 415286
Item number: TGM-T6659-100mg
Description: SB 415286 is a potent GSK3alpha inhibitor with IC50/Ki of 78 nM/31 nM with equally effective inhibition of GSK-3beta. Target: GSK-3, Apoptosis. Smiles: Oc1ccc(NC2=C(C(=O)NC2=O)c2ccccc2[N+]([O-])=O)cc1Cl. References: Coghlan MP, et al. Chem Biol, 2000, 7(10), 793-803.
| Keywords: | SB415286 |
| Application: | Potent selective cell permeable ATP-competitive inhibitor of GSK3 inhibitor |
| CAS | 264218-23-7 |
| MW: | 359.72 D |
From 42.00€
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(E/Z)-BIO-acetoxime
Item number: TGM-T61890-10mg
Description: (E/Z) - BIO-acetoxime is effective and selective GSK-3 alpha/beta Inhibitors. For GSK-3 alpha/beta, CDK5/p25, CDK2/cyclin A and CDK1/cyclin B, IC50 are 10nM, 2.4 µM, 4.3 µ M, 63 µ M, respectively?. Target: Others. Smiles: N(OC(C)=O)=C1C(NC=2C1=CC=CC2)=C3C=4C(NC3=O)=CC(Br)=CC4
| Application: | GSK3alpha/beta inhibitor |
| CAS | 740841-15-0 |
| MW: | 398.21 D |
From 77.00€
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Indirubin
Item number: TGM-T6169-100mg
Description: Indirubin (Couroupitine B) is a potent inhibitor of cyclin-dependent kinases and GSK-3beta, with IC50 values of approximately 5 µM and 0.6 µM, respectively. Target: Raf, GSK-3, CDK, Apoptosis. Smiles: O=C1Nc2ccccc2C1=C1Nc2ccccc2C1=O. References: Hoessel R, et al. Nat Cell Biol, 1999, 1(1), 60-67.
| Keywords: | Couroupitine B, NSC 105327, Indigopurpurin, Indigo red |
| Application: | GSK-3 inhibitor, CDK1/5 inhibitor |
| CAS | 479-41-4 |
| MW: | 262.26 D |
From 45.00€
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BIO
Item number: Cay13123-5
BIO is a cell-permeable bis-indolo (indirubin) compound that acts as a highly potent, selective, reversible, and ATP-competitive inhibitor of GSK3alpha/beta (IC50 = 5 nM). Its specificity has been tested against various cyclin-dependent kinases (CDKs) (IC50s = 83, 300, 320, and 10,000 nM for Cdk5/p25, Cdk2/A,...
| Keywords: | GSK3 Inhibitor IX, 6-Bromoindirubin-3'-oxime, MLS 2052,... |
| Application: | GSK-3 inhibitor |
| CAS | 667463-62-9 |
| MW: | 356.2 D |
From 44.00€
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Anti-GSK3A
Item number: CSB-PA002836.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Keywords: | Anti-GSK3A, Anti-GSK-3 alpha, EC=2.7.11.26, Anti-Glycogen synthase kinase-3 alpha, Anti-Serine/threonine-protein kinase... |
| Application: | ELISA, WB, IHC, IP |
| Host: | Rabbit |
| Species reactivity: | human, mouse, rat |
From 126.00€
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