51 products were found matching "K08726"!

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PHOME
PHOME

Item number: Cay10009134-10

EpETrE metabolites of arachidonic acid such as 11(12-EpETrE and 14(15)-EpETrE have been identified as endothelium derived hyperpolarizing factors with vasodilator activity. Soluble epoxide hydrolase (sEH) catalyzes the conversion of EpETrEs to the corresponding DiHETrEs thereby diminishing their activity. Inhibitors...
Keywords: 3-phenyl-cyano(6-methoxy-2-naphthalenyl)methyl ester-2-oxiraneacetic acid
Application: sEH inhibitor screening
CAS 1028430-42-3
MW: 373.4 D
From 54.00€ *
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TPPU
TPPU

Item number: Cay11120-1

Soluble epoxide hydrolase (sEH) converts epoxides to their corresponding diols. Inhibitors of sEH have anti-inflammatory, anti-hypertensive, neuroprotective, and cardioprotective effects. TPPU is a potent inhibitor of both human and mouse sEH (IC50 = 3.7 and 2.8 nM, respectively). The pharmacokinetics of this...
Keywords: N-[1-(1-oxopropyl)-4-piperidinyl]-N'-[4-(trifluoromethoxy)phenyl)-urea
Application: sEH inhibitor
CAS 1222780-33-7
MW: 359.3 D
From 44.00€ *
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trans-AUCB
trans-AUCB

Item number: TGM-T17158-5mg

Description: trans-AUCB (t-AUCB) is an effective and selective soluble epoxide hydrolase inhibitor, with IC50 values of 1.3 nM for hsEH, 8 nM for mouse sEH, and 8 nM for rat sEH. Target: Epoxide Hydrolase. Smiles: OC(=O)c1ccc(OC2CCC(CC2)NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1. References: Li J, et al. t-AUCB, an improved...
Keywords: t-AUCB
Application: Soluble epoxide hydrolase inhibitor
CAS 885012-33-9
MW: 412.52 D
From 45.00€ *
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Soluble epoxide hydrolase inhibitor
Soluble epoxide hydrolase inhibitor

Item number: TGM-T12974-100mg

Description: Soluble epoxide hydrolase inhibitor is a soluble epoxide hydrolase inhibitor (human soluble epoxide hydrolase (h-sEH) with pIC50 of 8.4). Target: Others. Smiles: O=C1N2C(=NN1CC(F)F)C=CC(C(NCC3=C(OC(F)(F)F)C=C(C#N)C=C3)=O)=C2. References: 3-OXO-2, 3-DIHYDRO- [1,2, 4] TRIAZOLO [4, 3-A]PYRIDINES AS SOLUBLE...
Application: Soluble epoxide hydrolase inhibitor
CAS 1241826-88-9
MW: 441.31 D
From 1,520.00€ *
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PTUPB
PTUPB

Item number: TGM-T12580-100mg

Description: PTUPB is a potent dual inhibitor of sEH and COX-2 enzymes with IC50 values of 0.9 nM and 1.26 µM, respectively. Target: COX, Epoxide Hydrolase. Smiles: NS(=O)(=O)c1ccc(cc1)-n1nc(CCCNC(=O)Nc2ccc(cc2)C(F)(F)F)cc1-c1ccccc1. References: Sun CC, et al. PTUPB ameliorates high-fat diet-induced non-alcoholic...
Application: SEH / COX-2 dual inhibitor
CAS 1287761-01-6
MW: 543.56 D
From 74.00€ *
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UC-1728
UC-1728

Item number: TGM-T17196-100mg

Description: UC-1728 (t-TUCB) is an effective rabbit soluble epoxide hydrolase inhibitor (IC50: 2 nM on rabbit liver). Target: Epoxide Hydrolase. Smiles: O([C@H]1CC[C@H](NC(NC2=CC=C(OC(F)(F)F)C=C2)=O)CC1)C3=CC=C(C(O)=O)C=C3
Keywords: t-TUCB
Application: sEH (soluble epoxide hydrolase) inhibitor
CAS 948304-40-3
MW: 438.4 D
From 37.00€ *
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CAY10640
CAY10640

Item number: TGM-T38367-100mg

Description: CAY10640 (sEH inhibitor-1) is a potent, orally active, water-soluble epoxide hydrolase (sEH) inhibitor that inhibits sEH in humans and mice with IC50s of 0.4 and 5.3 nM, respectively. Target: Epoxide Hydrolase. Smiles: C(=O)(C1CC1)N2CCC(NC(NC3=CC=C(OC(F)(F)F)C=C3)=O)CC2. References: Rose TE,et al....
Keywords: sEH inhibitor-1
Application: Soluble epoxide hydrolase (sEH) inhibitor
CAS 1208549-68-1
MW: 371.35 D
From 176.00€ *
Review
TPPU
TPPU

Item number: TGM-T7199-100mg

Description: TPPU is a potent inhibitor of both human and mouse sEH (IC50 of 3.7 and 2.8 nM, respectively). Target: Epoxide Hydrolase. Smiles: CCC(=O)N1CCC(CC1)NC(=O)Nc1ccc(OC(F)(F)F)cc1. References: Pharmacokinetics and in vivo potency of soluble epoxide hydrolase inhibitors in cynomolgus monkeys[J]. British...
Application: sEH inhibitor
CAS 1222780-33-7
MW: 359.34 D
From 31.00€ *
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EPHX2 Protein, Human, Recombinant (His)
EPHX2 Protein, Human, Recombinant (His)

Item number: TGM-TMPY-00410-100ug

Description: Genetic variation in EPHX2 was significantly associated with risk of incident CHD in Caucasians, implicating EPHX2 as a potential cardiovascular disease-susceptibility gene. Single nucleotide polymorphisms (SNPs) in the human EPHX2 gene had been implicated in susceptibility to cardiovascular disease,...
Keywords: epoxide hydrolase 2, cytoplasmic, CEH, SEH
MW: 65 kD
699.00€ *
Review
Epoxide hydrolase 2 (EPHX2), human, recombinant
Epoxide hydrolase 2 (EPHX2), human, recombinant

Item number: CSB-EP007735HU.1

Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 1-555aa. Protein Length: Full Length. Tag Info: N-terminal 6xHis-SUMO-tagged. Target Protein Sequence: MTLRAAVFDL DGVLALPAVF GVLGRTEEAL ALPRGLLNDA FQKGGPEGAT TRLMKGEITL SQWIPLMEEN CRKCSETAKV CLPKNFSIKE IFDKAISARK INRPMLQAAL MLRKKGFTTA ILTNTWLDDR...
Keywords: CEH, SEH, Epoxide hydratase, Soluble epoxide hydrolase, Lipid-phosphate phosphatase, Cytosolic epoxide hydrolase 2,...
Application: Activity not tested
Expressed in: E.coli
Origin: human
MW: 78.6 kD
From 219.00€ *
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Soluble Epoxide Hydrolase (human, recombinant)
Soluble Epoxide Hydrolase (human, recombinant)

Item number: Cay10011669-50

Soluble epoxide hydrolase (sEH) is a member of the alpha/beta-hydrolase fold enzyme family that catalyzes the hydrolysis of bioactive fatty acid epoxides to inactive vicinal diols. It is a homodimer in which each subunit is composed of two domains, a C-terminal epoxide hydrolase domain and an N-terminal phosphatase...
Keywords: CEH, CEH, Epoxide hydratase, Epoxide hydratase, Lipid-phosphate phosphatase, Lipid-phosphate phosphatase, Cytosolic...
Application: Enzyme activity
MW: 64 kD
526.00€ *
Review
CAY10640
CAY10640

Item number: Cay10642-1

Soluble epoxide hydrolase (sEH) inhibitors have important therapeutic use by increasing the in vivo concentration of EETs and other fatty acid epoxides, resulting in anti-inflammatory, antihypertensive, neuroprotective, and cardioprotective effects. CAY10640 is a 1-aryl-3-(1-acylpiperidin-4-yl)urea analog that...
Keywords: sEHi, Soluble Epoxide Hydrolase Inhibitor, N-[1-(cyclopropylcarbonyl)-4-piperidinyl]-N'-[4-(trifluoromethoxy)phenyl]-urea
Application: Soluble epoxide hydrolase (sEH) inhibitor
CAS 1208549-68-1
MW: 371.4 D
From 74.00€ *
Review
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