51 products were found matching "K08726"!
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PHOME
Item number: Cay10009134-10
EpETrE metabolites of arachidonic acid such as 11(12-EpETrE and 14(15)-EpETrE have been identified as endothelium derived hyperpolarizing factors with vasodilator activity. Soluble epoxide hydrolase (sEH) catalyzes the conversion of EpETrEs to the corresponding DiHETrEs thereby diminishing their activity. Inhibitors...
| Keywords: | 3-phenyl-cyano(6-methoxy-2-naphthalenyl)methyl ester-2-oxiraneacetic acid |
| Application: | sEH inhibitor screening |
| CAS | 1028430-42-3 |
| MW: | 373.4 D |
From 54.00€
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TPPU
Item number: Cay11120-1
Soluble epoxide hydrolase (sEH) converts epoxides to their corresponding diols. Inhibitors of sEH have anti-inflammatory, anti-hypertensive, neuroprotective, and cardioprotective effects. TPPU is a potent inhibitor of both human and mouse sEH (IC50 = 3.7 and 2.8 nM, respectively). The pharmacokinetics of this...
| Keywords: | N-[1-(1-oxopropyl)-4-piperidinyl]-N'-[4-(trifluoromethoxy)phenyl)-urea |
| Application: | sEH inhibitor |
| CAS | 1222780-33-7 |
| MW: | 359.3 D |
From 44.00€
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trans-AUCB
Item number: TGM-T17158-5mg
Description: trans-AUCB (t-AUCB) is an effective and selective soluble epoxide hydrolase inhibitor, with IC50 values of 1.3 nM for hsEH, 8 nM for mouse sEH, and 8 nM for rat sEH. Target: Epoxide Hydrolase. Smiles: OC(=O)c1ccc(OC2CCC(CC2)NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1. References: Li J, et al. t-AUCB, an improved...
| Keywords: | t-AUCB |
| Application: | Soluble epoxide hydrolase inhibitor |
| CAS | 885012-33-9 |
| MW: | 412.52 D |
From 45.00€
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Soluble epoxide hydrolase inhibitor
Item number: TGM-T12974-100mg
Description: Soluble epoxide hydrolase inhibitor is a soluble epoxide hydrolase inhibitor (human soluble epoxide hydrolase (h-sEH) with pIC50 of 8.4). Target: Others. Smiles: O=C1N2C(=NN1CC(F)F)C=CC(C(NCC3=C(OC(F)(F)F)C=C(C#N)C=C3)=O)=C2. References: 3-OXO-2, 3-DIHYDRO- [1,2, 4] TRIAZOLO [4, 3-A]PYRIDINES AS SOLUBLE...
| Application: | Soluble epoxide hydrolase inhibitor |
| CAS | 1241826-88-9 |
| MW: | 441.31 D |
From 1,520.00€
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PTUPB
Item number: TGM-T12580-100mg
Description: PTUPB is a potent dual inhibitor of sEH and COX-2 enzymes with IC50 values of 0.9 nM and 1.26 µM, respectively. Target: COX, Epoxide Hydrolase. Smiles: NS(=O)(=O)c1ccc(cc1)-n1nc(CCCNC(=O)Nc2ccc(cc2)C(F)(F)F)cc1-c1ccccc1. References: Sun CC, et al. PTUPB ameliorates high-fat diet-induced non-alcoholic...
| Application: | SEH / COX-2 dual inhibitor |
| CAS | 1287761-01-6 |
| MW: | 543.56 D |
From 74.00€
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UC-1728
Item number: TGM-T17196-100mg
Description: UC-1728 (t-TUCB) is an effective rabbit soluble epoxide hydrolase inhibitor (IC50: 2 nM on rabbit liver). Target: Epoxide Hydrolase. Smiles: O([C@H]1CC[C@H](NC(NC2=CC=C(OC(F)(F)F)C=C2)=O)CC1)C3=CC=C(C(O)=O)C=C3
| Keywords: | t-TUCB |
| Application: | sEH (soluble epoxide hydrolase) inhibitor |
| CAS | 948304-40-3 |
| MW: | 438.4 D |
From 37.00€
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CAY10640
Item number: TGM-T38367-100mg
Description: CAY10640 (sEH inhibitor-1) is a potent, orally active, water-soluble epoxide hydrolase (sEH) inhibitor that inhibits sEH in humans and mice with IC50s of 0.4 and 5.3 nM, respectively. Target: Epoxide Hydrolase. Smiles: C(=O)(C1CC1)N2CCC(NC(NC3=CC=C(OC(F)(F)F)C=C3)=O)CC2. References: Rose TE,et al....
| Keywords: | sEH inhibitor-1 |
| Application: | Soluble epoxide hydrolase (sEH) inhibitor |
| CAS | 1208549-68-1 |
| MW: | 371.35 D |
From 176.00€
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TPPU
Item number: TGM-T7199-100mg
Description: TPPU is a potent inhibitor of both human and mouse sEH (IC50 of 3.7 and 2.8 nM, respectively). Target: Epoxide Hydrolase. Smiles: CCC(=O)N1CCC(CC1)NC(=O)Nc1ccc(OC(F)(F)F)cc1. References: Pharmacokinetics and in vivo potency of soluble epoxide hydrolase inhibitors in cynomolgus monkeys[J]. British...
| Application: | sEH inhibitor |
| CAS | 1222780-33-7 |
| MW: | 359.34 D |
From 31.00€
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EPHX2 Protein, Human, Recombinant (His)
Item number: TGM-TMPY-00410-100ug
Description: Genetic variation in EPHX2 was significantly associated with risk of incident CHD in Caucasians, implicating EPHX2 as a potential cardiovascular disease-susceptibility gene. Single nucleotide polymorphisms (SNPs) in the human EPHX2 gene had been implicated in susceptibility to cardiovascular disease,...
| Keywords: | epoxide hydrolase 2, cytoplasmic, CEH, SEH |
| MW: | 65 kD |
699.00€
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Epoxide hydrolase 2 (EPHX2), human, recombinant
Item number: CSB-EP007735HU.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 1-555aa. Protein Length: Full Length. Tag Info: N-terminal 6xHis-SUMO-tagged. Target Protein Sequence: MTLRAAVFDL DGVLALPAVF GVLGRTEEAL ALPRGLLNDA FQKGGPEGAT TRLMKGEITL SQWIPLMEEN CRKCSETAKV CLPKNFSIKE IFDKAISARK INRPMLQAAL MLRKKGFTTA ILTNTWLDDR...
| Keywords: | CEH, SEH, Epoxide hydratase, Soluble epoxide hydrolase, Lipid-phosphate phosphatase, Cytosolic epoxide hydrolase 2,... |
| Application: | Activity not tested |
| Expressed in: | E.coli |
| Origin: | human |
| MW: | 78.6 kD |
From 219.00€
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Soluble Epoxide Hydrolase (human, recombinant)
Item number: Cay10011669-50
Soluble epoxide hydrolase (sEH) is a member of the alpha/beta-hydrolase fold enzyme family that catalyzes the hydrolysis of bioactive fatty acid epoxides to inactive vicinal diols. It is a homodimer in which each subunit is composed of two domains, a C-terminal epoxide hydrolase domain and an N-terminal phosphatase...
| Keywords: | CEH, CEH, Epoxide hydratase, Epoxide hydratase, Lipid-phosphate phosphatase, Lipid-phosphate phosphatase, Cytosolic... |
| Application: | Enzyme activity |
| MW: | 64 kD |
526.00€
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CAY10640
Item number: Cay10642-1
Soluble epoxide hydrolase (sEH) inhibitors have important therapeutic use by increasing the in vivo concentration of EETs and other fatty acid epoxides, resulting in anti-inflammatory, antihypertensive, neuroprotective, and cardioprotective effects. CAY10640 is a 1-aryl-3-(1-acylpiperidin-4-yl)urea analog that...
| Keywords: | sEHi, Soluble Epoxide Hydrolase Inhibitor, N-[1-(cyclopropylcarbonyl)-4-piperidinyl]-N'-[4-(trifluoromethoxy)phenyl]-urea |
| Application: | Soluble epoxide hydrolase (sEH) inhibitor |
| CAS | 1208549-68-1 |
| MW: | 371.4 D |
From 74.00€
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