- Search results for K08726
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51 products were found matching "K08726"!
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Item number: Cay10009134-10
EpETrE metabolites of arachidonic acid such as 11(12-EpETrE and 14(15)-EpETrE have been identified as endothelium derived hyperpolarizing factors with vasodilator activity. Soluble epoxide hydrolase (sEH) catalyzes the conversion of EpETrEs to the corresponding DiHETrEs thereby diminishing their activity. Inhibitors...
Keywords: | 3-phenyl-cyano(6-methoxy-2-naphthalenyl)methyl ester-2-oxiraneacetic acid |
Application: | sEH inhibitor screening |
CAS | 1028430-42-3 |
MW: | 373.4 D |
From 54.00€
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Item number: Cay11120-1
Soluble epoxide hydrolase (sEH) converts epoxides to their corresponding diols. Inhibitors of sEH have anti-inflammatory, anti-hypertensive, neuroprotective, and cardioprotective effects. TPPU is a potent inhibitor of both human and mouse sEH (IC50 = 3.7 and 2.8 nM, respectively). The pharmacokinetics of this...
Keywords: | N-[1-(1-oxopropyl)-4-piperidinyl]-N'-[4-(trifluoromethoxy)phenyl)-urea |
Application: | sEH inhibitor |
CAS | 1222780-33-7 |
MW: | 359.3 D |
From 44.00€
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Item number: TGM-T17158-5mg
Description: trans-AUCB (t-AUCB) is an effective and selective soluble epoxide hydrolase inhibitor, with IC50 values of 1.3 nM for hsEH, 8 nM for mouse sEH, and 8 nM for rat sEH. Target: Epoxide Hydrolase. Smiles: OC(=O)c1ccc(OC2CCC(CC2)NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1. References: Li J, et al. t-AUCB, an improved...
Keywords: | t-AUCB |
Application: | Soluble epoxide hydrolase inhibitor |
CAS | 885012-33-9 |
MW: | 412.52 D |
From 45.00€
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Item number: TGM-T12974-100mg
Description: Soluble epoxide hydrolase inhibitor is a soluble epoxide hydrolase inhibitor (human soluble epoxide hydrolase (h-sEH) with pIC50 of 8.4). Target: Others. Smiles: O=C1N2C(=NN1CC(F)F)C=CC(C(NCC3=C(OC(F)(F)F)C=C(C#N)C=C3)=O)=C2. References: 3-OXO-2, 3-DIHYDRO- [1,2, 4] TRIAZOLO [4, 3-A]PYRIDINES AS SOLUBLE...
Application: | Soluble epoxide hydrolase inhibitor |
CAS | 1241826-88-9 |
MW: | 441.31 D |
From 1,520.00€
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Item number: TGM-T12580-100mg
Description: PTUPB is a potent dual inhibitor of sEH and COX-2 enzymes with IC50 values of 0.9 nM and 1.26 µM, respectively. Target: COX, Epoxide Hydrolase. Smiles: NS(=O)(=O)c1ccc(cc1)-n1nc(CCCNC(=O)Nc2ccc(cc2)C(F)(F)F)cc1-c1ccccc1. References: Sun CC, et al. PTUPB ameliorates high-fat diet-induced non-alcoholic...
Application: | SEH / COX-2 dual inhibitor |
CAS | 1287761-01-6 |
MW: | 543.56 D |
From 74.00€
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Item number: TGM-T17196-100mg
Description: UC-1728 (t-TUCB) is an effective rabbit soluble epoxide hydrolase inhibitor (IC50: 2 nM on rabbit liver). Target: Epoxide Hydrolase. Smiles: O([C@H]1CC[C@H](NC(NC2=CC=C(OC(F)(F)F)C=C2)=O)CC1)C3=CC=C(C(O)=O)C=C3
Keywords: | t-TUCB |
Application: | sEH (soluble epoxide hydrolase) inhibitor |
CAS | 948304-40-3 |
MW: | 438.4 D |
From 37.00€
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Item number: TGM-T38367-100mg
Description: CAY10640 (sEH inhibitor-1) is a potent, orally active, water-soluble epoxide hydrolase (sEH) inhibitor that inhibits sEH in humans and mice with IC50s of 0.4 and 5.3 nM, respectively. Target: Epoxide Hydrolase. Smiles: C(=O)(C1CC1)N2CCC(NC(NC3=CC=C(OC(F)(F)F)C=C3)=O)CC2. References: Rose TE,et al....
Keywords: | sEH inhibitor-1 |
Application: | Soluble epoxide hydrolase (sEH) inhibitor |
CAS | 1208549-68-1 |
MW: | 371.35 D |
From 176.00€
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Item number: TGM-T7199-100mg
Description: TPPU is a potent inhibitor of both human and mouse sEH (IC50 of 3.7 and 2.8 nM, respectively). Target: Epoxide Hydrolase. Smiles: CCC(=O)N1CCC(CC1)NC(=O)Nc1ccc(OC(F)(F)F)cc1. References: Pharmacokinetics and in vivo potency of soluble epoxide hydrolase inhibitors in cynomolgus monkeys[J]. British...
Application: | sEH inhibitor |
CAS | 1222780-33-7 |
MW: | 359.34 D |
From 31.00€
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Item number: TGM-TMPY-00410-100ug
Description: Genetic variation in EPHX2 was significantly associated with risk of incident CHD in Caucasians, implicating EPHX2 as a potential cardiovascular disease-susceptibility gene. Single nucleotide polymorphisms (SNPs) in the human EPHX2 gene had been implicated in susceptibility to cardiovascular disease,...
Keywords: | epoxide hydrolase 2, cytoplasmic, CEH, SEH |
MW: | 65 kD |
699.00€
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Item number: CSB-EP007735HU.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 1-555aa. Protein Length: Full Length. Tag Info: N-terminal 6xHis-SUMO-tagged. Target Protein Sequence: MTLRAAVFDL DGVLALPAVF GVLGRTEEAL ALPRGLLNDA FQKGGPEGAT TRLMKGEITL SQWIPLMEEN CRKCSETAKV CLPKNFSIKE IFDKAISARK INRPMLQAAL MLRKKGFTTA ILTNTWLDDR...
Keywords: | CEH, SEH, Epoxide hydratase, Soluble epoxide hydrolase, Lipid-phosphate phosphatase, Cytosolic epoxide hydrolase 2,... |
Application: | Activity not tested |
Expressed in: | E.coli |
Origin: | human |
MW: | 78.6 kD |
From 219.00€
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Item number: Cay10011669-50
Soluble epoxide hydrolase (sEH) is a member of the alpha/beta-hydrolase fold enzyme family that catalyzes the hydrolysis of bioactive fatty acid epoxides to inactive vicinal diols. It is a homodimer in which each subunit is composed of two domains, a C-terminal epoxide hydrolase domain and an N-terminal phosphatase...
Keywords: | CEH, CEH, Epoxide hydratase, Epoxide hydratase, Lipid-phosphate phosphatase, Lipid-phosphate phosphatase, Cytosolic... |
Application: | Enzyme activity |
MW: | 64 kD |
526.00€
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Item number: Cay10642-1
Soluble epoxide hydrolase (sEH) inhibitors have important therapeutic use by increasing the in vivo concentration of EETs and other fatty acid epoxides, resulting in anti-inflammatory, antihypertensive, neuroprotective, and cardioprotective effects. CAY10640 is a 1-aryl-3-(1-acylpiperidin-4-yl)urea analog that...
Keywords: | sEHi, Soluble Epoxide Hydrolase Inhibitor, N-[1-(cyclopropylcarbonyl)-4-piperidinyl]-N'-[4-(trifluoromethoxy)phenyl]-urea |
Application: | Soluble epoxide hydrolase (sEH) inhibitor |
CAS | 1208549-68-1 |
MW: | 371.4 D |
From 74.00€
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