324 products were found matching "K08557"!

This nuclear receptor assay system utilizes proprietary non-human mammalian cells engineered to provide constitutive, high-level expression of full-length, unmodified human androgen receptor (NR3C4), a ligand-dependent transcription factor commonly referred to as AR. INDIGO's reporter cells include the luciferase...

Testosterone-d3 (Cay-32986) is an analytical reference standard intended for use as an internal standard for the quantification of testosterone (Cay-15645, Cay-ISO00154, Cay-ISO60154) by GC- or LC-MS. Testosterone is categorized as an anabolic androgenic steroid. It is an endogenous metabolite of androstenedione...

The androgen receptor (AR) functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes [taken from NCBI Entrez Gene (Gene ID:...

The androgen receptor (AR) functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes [taken from NCBI Entrez Gene (Gene ID:...

Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 1-400aa. Protein Length: Partial. Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged. Target Protein Sequence: MEVQLGLGRV YPRPPSKTYR GAFQNLFQSV REVIQNPGPR HPEAASAAPP GASLLLLQQQ QQQQQQQQQQ QQQQQQQQQQ ETSPRQQQQQ QGEDGSPQAH RRGPTGYLVL...

Protein function: Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits...

Masofaniten is an androgen receptor N-terminal transactivation domain inhibitor (ARTADI). It binds to the tryptophan residues in positions 397 (W397) and W433 in the AR TAD.Formal Name: N-[4-[[4-[1-[3-chloro-4-(2-chloroethoxy)-5-cyanophenyl]-1-methylethyl]phenoxy]methyl]-2-pyrimidinyl]-methanesulfonamide. CAS...

(S)-SKBG-1 is an inactive enantiomer of (R)-SKBG-1 (Cay-42091), a degrader of mRNA encoding the androgen receptor (AR).Formal Name: (2S)-4-(2-chloroacetyl)-N-[(4-methoxyphenyl)methyl]-1-[(4-methoxyphenyl)sulfonyl]-2-piperazinecarboxamide. CAS Number: 2955618-24-1. Molecular Formula: C22H26ClN3O6S. Formula Weight:...

5alpha-dihydro-11-keto Testosterone-d3 is intended for use as an internal standard for the quantification of 5alpha-dihydro-11-keto testosterone (Cay-20200) by GC- or LC-MS. 5alpha-dihydro-11-keto Testosterone is a metabolite of 11beta-hydroxyandrostenedione and 11beta-hydroxytestosterone that has been shown to act...

Description: Darolutamide (BAY-1841788) is an androgen receptor (AR) antagonist that blocks AR nuclear translocation (Ki: 11 nM). Target: Androgen Receptor. Smiles: C[C@@H](Cn1ccc(n1)-c1ccc(C#N)c(Cl)c1)NC(=O)c1cc([nH]n1)C(C)O. References: Moilanen AM, et al. Sci Rep. 2015, 5:12007. doi: 10.1038/srep12007.

Description: MI-136 inhibits expression of androgen receptor (AR) target genes that DHT induced. Target: Epigenetic Reader Domain, Androgen Receptor, Apoptosis. Smiles: FC(F)(F)Cc1cc2c(NC3CCN(Cc4ccc5[nH]c(cc5c4)C#N)CC3)ncnc2s1. References: Malik R, et al. Nat Med. 2015, 21(4):344-352.

Description: Flutamide-d7 is intended for use as an internal standard for the quantification of flutamide by GC- or LC-MS. Flutamide is an androgen receptor antagonist and prodrug form of 2-hydroxy flutamide. Flutamide is converted to 2-hydroxy flutamide by the cytochrome P450 (CYP) isoform CYP1A2 in human liver...