174 products were found matching "K08551"!

Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 2-323aa. Protein Length: Partial of Isoform 3. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: DIKNSPSSLN SPSSYNCSQS ILPLEHGSIY IPSSYVDSHH EYPAMTFYSP AVMNYSIPSN VTNLEGGPGR QTTSPNVLWP TPGHLSPLVV HRQLSHLYAE PQKSPWCEAR SLEHTLPVNR ETLKRKVSGN...

Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 2-323aa. Protein Length: Partial of Isoform 3. Tag Info: N-terminal 6xHis-SUMO-tagged. Target Protein Sequence: DIKNSPSSLN SPSSYNCSQS ILPLEHGSIY IPSSYVDSHH EYPAMTFYSP AVMNYSIPSN VTNLEGGPGR QTTSPNVLWP TPGHLSPLVV HRQLSHLYAE PQKSPWCEAR SLEHTLPVNR...

Tamoxifen is an estrogen receptor antagonist (IC50 = 45 nM for the rabbit receptor). It reduces the proliferation of MCF-7 breast cancer cells when used at a concentration of 10 µM. Tamoxifen is active against S. cerevisiae, C. neoformans, and five Candida species (MICs = 12, 64, and 8-64 µg/ml, respectively). It...

Dienestrol is a synthetic non-steroidal estrogen receptor (ER) agonist and an active metabolite of diethylstilbestrol (Cay-10006876). Dienestrol binds to ERalpha and ERbeta (Kis = 0.05 and 0.03 nM, respectively) and activates ERalpha in a reporter assay (EC50 = 3.23 nM). It also inhibits porcine microtubule assembly...

(E/Z)-4-hydroxy Tamoxifen is an active metabolite of tamoxifen (Cay-13258). It is formed from tamoxifen by the cytochrome P450 (CYP) isoform CYP2D6. (E/Z)-4-hydroxy Tamoxifen is cytotoxic to MCF-7 and MDA-MB-231 breast cancer cells (IC50s = 27 and 18 µM, respectively). It also stimulates LC3 lipidation and the...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat ERb. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat ERb. Next, Avidin...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human ERb. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human ERb. Next,...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse ERb. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse ERb. Next,...

Tamoxifen is an estrogen receptor antagonist (IC50 = 45 nM for the rabbit receptor). It reduces the proliferation of MCF-7 breast cancer cells when used at a concentration of 10 µM. Tamoxifen is active against S. cerevisiae, C. neoformans, and five Candida species (MICs = 12, 64, and 8-64 µg/ml, respectively). It...

Erteberel is an estrogen receptor beta (ERbeta) agonist. It is selective for ERbeta over ERalpha in reporter assays using PC3 cells expressing the human receptors (EC50s = 0.66 and 19.4 nM, respectively). Ertebrel (5 µM) induces apoptosis and cell cycle arrest at the G2/M phase in U87MG and U251 glioblastoma cells....

Synthetic. Chemical. CAS: 10540-29-1. Formula: C26H29NO. MW: 371.51. Synthetic. Selective estrogen receptor modulator (SERM) used as adjuvant therapy for estrogen-dependent breast cancer. Antagonist of ER action in breast tissue and breast cancer cells and ER agonist in bone, uterus, and the cardiovasculature...

Bazedoxifene (acetate) is a third generation selective estrogen receptor modulator (SERM). It is an indole-based ER ligand that binds to both ERalpha (IC50 = 26 nM) and ERbeta (IC50 = 99 nM). Bazedoxifene (actetate) antagonizes 17beta-estradiol-dependent MCF-7 and T47D breast cancer cell proliferation in vitro as...