422 products were found matching "K08550"!
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Tamoxifen
Item number: Cay13258-1
Tamoxifen is an estrogen receptor antagonist (IC50 = 45 nM for the rabbit receptor). It reduces the proliferation of MCF-7 breast cancer cells when used at a concentration of 10 µM. Tamoxifen is active against S. cerevisiae, C. neoformans, and five Candida species (MICs = 12, 64, and 8-64 µg/ml, respectively). It...
| Keywords: | 2-[4-[(1Z)-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethyl-ethanamine |
| Application: | Estrogen receptor modulator |
| CAS | 10540-29-1 |
| MW: | 371.5 D |
From 77.00€
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Zearalanone
Item number: TGM-T13391-1mg
Description: Zearalenone is a nonsteroidal estrogenic mycotoxin produced by Fusarium species that colonizes various grains. Target: Others. Smiles: C[C@H]1CCCC(=O)CCCCCc2cc(O)cc(O)c2C(=O)O1. References: Zöllner P, et al. Triacsin Concentration levels of zearalenone and its metabolites in urine, muscle tissue, and...
| Application: | Estrogen receptor agonist, androgen receptor antagonist |
| CAS | 5975-78-0 |
| MW: | 320.38 D |
From 120.00€
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Tamoxifen-d5
Item number: TGM-T13076-10mg
Description: Tamoxifen-d5 is a deuterium labeled Tamoxifen. Tamoxifen is a selective modulator of estrogen receptor (SERM). Tamoxifen is a potent activator of Hsp90 and enhances the Hsp90 molecular chaperone ATPase activity. Smiles: [2H]C([2H])([2H])C([2H])([2H])C(=C(/c1ccccc1)c1ccc(OCCN(C)C)cc1)\c1ccccc1....
| Keywords: | trans-Tamoxifen-d5, (Z)-Tamoxifen-d5, ICI 47699-d5 |
| Application: | MS, internal control, estrogen receptor 1/2 agonist/antagonist |
| CAS | 157698-32-3 |
| MW: | 376.55 D |
From 257.00€
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(R)-Equol
Item number: TGM-T13443-100mg
Description: (R)-Equol ((+)-Equol) is an ERalpha and ERbeta agonist with Kis of 27.4 and 15.4 nM, respectively. Target: Estrogen/progestogen Receptor. Smiles: OC1=CC=C(C=C1)[C@@H]1COC2=C(C1)C=CC(O)=C2. References: Setchell KD, et al. S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric...
| Keywords: | (+)-Equol |
| Application: | ERalpha agonist |
| CAS | 221054-79-1 |
| MW: | 242.27 D |
From 35.00€
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alpha-Zearalenol
Item number: TGM-T13542-1mg
Description: alpha-Zearalenol is one of the major metabolites of Zearalenone. alpha-Zearalenol has structural analogy to estrogen, thus alpha-Zearalenol can bind to estrogen receptors (ERs). Target: Estrogen Receptor/ERR. Smiles: C[C@H]1CCC[C@H](O)CCC\C=C\c2cc(O)cc(O)c2C(=O)O1. References: .Tatay E, et al....
| Application: | Estrogen receptor agonist, mycotoxin |
| CAS | 36455-72-8 |
| MW: | 320.38 D |
From 106.00€
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Elacestrant
Item number: TGM-T13674-100mg
Description: Elacestrant (RAD1901) with IC50s of 48 and 870 nM for ERalpha and ERbeta, respectively.Elacestrant is an orally available selective estrogen receptor degrader . Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor. Smiles: CCNCCc1ccc(CN(CC)c2cc(OC)ccc2[C@@H]2CCc3cc(O)ccc3C2)cc1. References:...
| Keywords: | RAD1901 |
| Application: | Targets estrogen receptor alpha (ESR1, NR3A1) |
| CAS | 722533-56-4 |
| MW: | 458.63 D |
From 144.00€
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Elacestrant dihydrochloride
Item number: TGM-T13675-100mg
Description: Elacestrant dihydrochloride (DA-DKRAD1901 dihydrochloride) is an orally available selective estrogen receptor degrader with IC50s of 48 for ERalpha and 870 nM for ERbeta, respectively. Target: Estrogen/progestogen Receptor. Smiles: Cl.Cl.CCNCCc1ccc(CN(CC)c2cc(OC)ccc2[C@@H]2CCc3cc(O)ccc3C2)cc1....
| Keywords: | RAD1901 dihydrochloride |
| Application: | Targets estrogen receptor alpha (ESR1, NR3A1) |
| CAS | 1349723-93-8 |
| MW: | 531.56 D |
From 119.00€
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ERD-308
Item number: TGM-T13685-100mg
Description: ERD-308 induces >95% of ER degradation at concentrations as low as 5 nM in both cell lines (DC50 (concentration causing 50% of protein degradation) of 0.17 nM and 0.43 nM in MCF-7 and T47D ER+ cells, respectively).ERD-308 is a highly potent PROTAC degrader of estrogen receptor (ER) for ER positive...
| Application: | Estrogen receptor degradation driving PROTAC |
| CAS | 2320561-35-9 |
| MW: | 1004.26 D |
From 895.00€
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CMP8
Item number: TGM-T14987-100mg
Description: CMP8 is a selective ligand for estrogen receptor. CMP8 binds to the mutant estrogen receptor ligand binding domain (ERLBD). CMP8 has IC50 values of 29 nM , 41 nM, 1100 nM and 2200 nM for MGERalpha, MGRERalpha, hERalpha and hERbeta, respectively. Target: Estrogen/progestogen Receptor, Estrogen...
| Application: | Mutant ERalpha antagonist, bump and hole ligand |
| CAS | 851107-28-3 |
| MW: | 528.08 D |
From 247.00€
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Ethynyl estradiol
Item number: TGM-T1424-100mg
Description: Ethynyl estradiol is a semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPT IVES. Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Endogenous...
| Keywords: | 17alpha-Ethynylestradiol, Ethinyl Estradiol |
| Application: | Targets estrogen receptor alpha (ESR1, NR3A1) |
| CAS | 57-63-6 |
| MW: | 296.4 D |
From 33.00€
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BHPI
Item number: TGM-T14553-100mg
Description: BHPI is a potent ERalpha inhibitor that blocks nuclear estrogen-ERalpha-regulated gene expression effectively. It triggers sustained ERalpha-dependent activation of the endoplasmic reticulum (EnR) stress sensor, notably the unfolded protein response (UPR), and consistently inhibits protein synthesis....
| Application: | ERalpha antagonist |
| CAS | 56632-39-4 |
| MW: | 331.36 D |
From 87.00€
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Propyl pyrazole triol
Item number: TGM-T16566-100mg
Description: Propyl pyrazole triol (PPT) is a selective agonist of estrogen receptor alpha (ERalpha), exhibiting a relative binding affinity of 49% for ERalpha, which is approximately 410 times higher than its affinity for estrogen receptor beta (ERbeta: 0.12%). Target: Estrogen/progestogen Receptor, Estrogen...
| Keywords: | PPT |
| Application: | ERalpha agonist |
| CAS | 263717-53-9 |
| MW: | 386.44 D |
From 38.00€
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