398 products were found matching "K08550"!
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Tamoxifen
Item number: Cay13258-1
Tamoxifen is an estrogen receptor antagonist (IC50 = 45 nM for the rabbit receptor). It reduces the proliferation of MCF-7 breast cancer cells when used at a concentration of 10 µM. Tamoxifen is active against S. cerevisiae, C. neoformans, and five Candida species (MICs = 12, 64, and 8-64 µg/ml, respectively). It...
| Keywords: | 2-[4-[(1Z)-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethyl-ethanamine |
| Application: | Estrogen receptor modulator |
| CAS | 10540-29-1 |
| MW: | 371.5 D |
From 77.00€
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LSZ-102
Item number: Cay41834-1
LSZ-102 is an estrogen receptor alpha (ERalpha) degrader (IC50 = 0.2 nM). It reduces 17beta-estradiol-induced transcription in a reporter assay using MCF-7 breast cancer cells expressing ERalpha (IC50 = 6 nM). LSZ-102 decreases the proliferation of MCF-7 cells (IC50 = 1.7 nM). In vivo, LSZ-102 (20 mg/kg per day)...
| Keywords: | 3-[4-[[2E-[2-(1,1-difluoroethyl)-4-fluorophenyl]-6-hydroxybenzo[b]thien-3-yl]oxy]phenyl]-2-propenoic acid |
| Application: | ERalpha degrader |
| CAS | 2135600-76-7 |
| MW: | 470.5 D |
From 62.00€
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Raloxifene
Item number: Cay41845-1
Raloxifene (Cay-41845) is an analytical reference standard categorized as a selective estrogen receptor modulator (SERM). It has been detected as an adverse analytical finding (AAF) during anti-doping testing. This product is intended for analytical forensic applications. This product is also available as a general...
| Keywords: | Keoxifene, LY156758, NSC 747974,... |
| Application: | Analytical reference standard, selective estrogen receptor modulator (SERM) |
| CAS | 84449-90-1 |
| MW: | 473.6 D |
From 150.00€
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CMP8
Item number: TGM-T14987-100mg
Description: CMP8 is a selective ligand for estrogen receptor. CMP8 binds to the mutant estrogen receptor ligand binding domain (ERLBD). CMP8 has IC50 values of 29 nM , 41 nM, 1100 nM and 2200 nM for MGERalpha, MGRERalpha, hERalpha and hERbeta, respectively. Target: Estrogen/progestogen Receptor, Estrogen...
| Application: | Mutant ERalpha antagonist, bump and hole ligand |
| CAS | 851107-28-3 |
| MW: | 528.08 D |
From 247.00€
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Ethynyl estradiol
Item number: TGM-T1424-100mg
Description: Ethynyl estradiol is a semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPT IVES. Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Endogenous...
| Keywords: | 17alpha-Ethynylestradiol, Ethinyl Estradiol |
| Application: | Targets estrogen receptor alpha (ESR1, NR3A1) |
| CAS | 57-63-6 |
| MW: | 296.4 D |
From 33.00€
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BHPI
Item number: TGM-T14553-100mg
Description: BHPI is a potent ERalpha inhibitor that blocks nuclear estrogen-ERalpha-regulated gene expression effectively. It triggers sustained ERalpha-dependent activation of the endoplasmic reticulum (EnR) stress sensor, notably the unfolded protein response (UPR), and consistently inhibits protein synthesis....
| Application: | ERalpha antagonist |
| CAS | 56632-39-4 |
| MW: | 331.36 D |
From 87.00€
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Propyl pyrazole triol
Item number: TGM-T16566-100mg
Description: Propyl pyrazole triol (PPT) is a selective agonist of estrogen receptor alpha (ERalpha), exhibiting a relative binding affinity of 49% for ERalpha, which is approximately 410 times higher than its affinity for estrogen receptor beta (ERbeta: 0.12%). Target: Estrogen/progestogen Receptor, Estrogen...
| Keywords: | PPT |
| Application: | ERalpha agonist |
| CAS | 263717-53-9 |
| MW: | 386.44 D |
From 38.00€
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17-Epiestriol
Item number: TGM-T36913-5mg
Description: 17-Epiestriol is a metabolite of estrone .1It is formed from estroneviaa 16alpha-hydroxy estrone intermediate by reduction of the C-17 ketone. 17-Epiestriol binds to estrogen receptor alpha (ERalpha) and ERbeta with relative binding affinities of 29 and 80 compared with 17beta-estradiol .2. Target:...
| Application: | Estrone metabolite |
| CAS | 1228-72-4 |
| MW: | 288.38 D |
1,275.00€
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AZD9496
Item number: TGM-T3975-100mg
Description: AZD9496 is an orally available selective estrogen receptor(ERalpha) antagonist, with potential antineoplastic activity. Target: Estrogen/progestogen Receptor, Estrogen Receptor/ERR. Smiles: C(C(C)(C)F)N1[C@@H](C2=C(C=3C(N2)=CC=CC3)C[C@H]1C)C4=C(F)C=C(/C=C/C(O)=O)C=C4F. References: Weir HM, et al....
| Application: | Estrogen receptor downregulator & antagonist |
| CAS | 1639042-08-2 |
| MW: | 442.47 D |
From 51.00€
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Lasofoxifene
Item number: TGM-T62119-10mg
Description: Lasofoxifene (CP-336156) is a selective, orally active estrogen receptor modulator (SERM) that inhibits the growth and metastasis of primary tumours and is also anti-osteoporotic. Target: Others. Smiles: OC=1C=C2C([C@H]([C@H](CC2)C3=CC=CC=C3)C4=CC=C(OCCN5CCCC5)C=C4)=CC1
| Application: | SERM |
| CAS | 180916-16-9 |
| MW: | 413.55 D |
From 289.00€
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H3B-5942
Item number: TGM-T5633-100mg
Description: H3B-5942 belongs to a class of ERalpha antagonists referred to as selective estrogen receptor covalent antagonists (SERCA). Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor. Smiles: CC\C(=C(\c1ccc(OCCNC\C=C\C(=O)N(C)C)cc1)c1ccc2[nH]ncc2c1)c1ccccc1. References: Discovery of Selective...
| Application: | Selective estrogen receptor covalent antagonist (SERCA) |
| CAS | 2052128-15-9 |
| MW: | 494.63 D |
From 77.00€
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Palazestrant
Item number: TGM-T72945-10mg
Description: Palazestrant (OP-1250) is an orally available and highly potent estrogen receptor antagonist and selective ER degrader with antitumor activity.Palazestrant inhibits 17b-estradiol (E2), inhibits MCF7 and CAMA-1 cell proliferation, and can be used in breast cancer research. Target: Estrogen/progestogen...
| Keywords: | OP1250, OP 1250, OP-1250 |
| Application: | Targets estrogen receptor alpha (ESR1, NR3A1) |
| CAS | 2092925-89-6 |
| MW: | 449.6 D |
From 286.00€
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