49 products were found matching "K08540"!
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Desmethyl Bosentan
Item number: TGM-T37351-1mg
Description: Desmethyl bosentan, an active metabolite of the endothelin receptor antagonist bosentan, activates the pregnane X receptor (PXR) in CV-1 monkey kidney cells expressing the human receptor in a reporter assay at a concentration of 25 µM. Target: Others. Smiles:...
| Application: | Bosentan active metabolite |
| CAS | 253688-61-8 |
| MW: | 537.59 D |
From 289.00€
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Specific PXR antagonist 70
Item number: TGM-T41255-100mg
Description: Specific PXR antagonist 70 is a selective pregnane X receptor (PXR) antagonist with an IC50 of 540 nM and Ki of 390 nM for human PCR and enhances the chemosensitivity of cancer cells. Target: Others. Smiles: COC1=CC=C(OC)C(=C1)N1N=NC(=C1C)S(=O)(=O)C1=CC=C(C=C1)C(C)(C)C. References: Chai SC, Lin W, Li Y,...
| Application: | PXR antagonist |
| CAS | 931314-31-7 |
| MW: | 415.51 D |
From 48.00€
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beta-Acids colupulone
Item number: TGM-T80696-1mg
Description: Colupulone, a bitter beta-acid, can be isolated from hops [1]. Smiles: O=C(C=1C(O)=C(C(=O)C(C1O)(CC=C(C)C)CC=C(C)C)CC=C(C)C)C(C)C
| Application: | Bioactive hop beta-acid |
| CAS | 468-27-9 |
| MW: | 400.55 D |
From 330.00€
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NR1I2 Protein, Human, Recombinant (His & Myc & SUMO)
Item number: TGM-TMPH-01793-100ug
Description: NR1I2 Protein, Human, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 69.8 kDa and the accession number is O75469.
| Keywords: | Pregnane X receptor, Nuclear receptor subfamily 1 group I member 2, Orphan nuclear receptor PAR1, Steroid and xenobiotic... |
| MW: | 69.8 kD |
From 193.00€
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12-Ketodeoxycholic acid
Item number: TGM-T14002-100mg
Description: 12-Ketodeoxycholic acid, a bile acid and kidney metabolite, serves as a detectable marker for kidney injury [1]. Target: Endogenous Metabolite. Smiles: C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@H](O)CC[C@]4(C)[C@H]3CC(=O)[C@]12C. References: Chen H, et al. Metabolomics insights into activated redox...
| Application: | DCA metabolite, human pregnane X receptor agonist |
| CAS | 5130-29-0 |
| MW: | 390.56 D |
From 56.00€
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Nuclear receptor subfamily 1 group I member 2 (NR1I2),...
Item number: CSB-EP016048HU.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 1-434aa. Protein Length: Full Length. Tag Info: N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged. Target Protein Sequence: MEVRPKESWN HADFVHCEDT ESVPGKPSVN ADEEVGGPQI CRVCGDKATG YHFNVMTCEG CKGFFRRAMK RNARLRCPFR KGACEITRKT RRQCQACRLR KCLESGMKKE...
| Keywords: | PXR, SXR, NR1I2, Pregnane X receptor, Orphan nuclear receptor PXR, Orphan nuclear receptor PAR1, Steroid and xenobiotic... |
| Application: | Activity not tested |
| Expressed in: | E.coli |
| Origin: | human |
| MW: | 69.8 kD |
From 213.00€
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Anti-NR1I2 / PXR
Item number: NSJ-RQ5593
0.5mg/ml if reconstituted with 0.2ml sterile DI water. In the field of molecular biology, the pregnane X receptor (PXR), also known as the steroid and xenobiotic sensing nuclear receptor (SXR) or nuclear receptor subfamily 1, group I, member 2 (NR1I2) is a protein that in humans is encoded by the NR1I2 (nuclear...
| Keywords: | Anti-PXR, Anti-SXR, Anti-NR1I2, Anti-Pregnane X receptor, Anti-Orphan nuclear receptor PXR, Anti-Orphan nuclear receptor... |
| Application: | WB, IHC (paraffin), FC, Direct ELISA |
| Host: | Rabbit |
| Species reactivity: | human, mouse, rat |
755.00€
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Rat PXR (Pregnane X Receptor) ELISA Kit
Item number: ELK-ELK6436.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat PXR. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat PXR. Next, Avidin...
| Keywords: | Pxr, Nr1i2, Pregnane X receptor, Orphan nuclear receptor PXR, Nuclear receptor subfamily 1 group I member 2 |
| Application: | ELISA |
| Species reactivity: | rat |
From 365.00€
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Human PXR (Pregnane X Receptor) ELISA Kit
Item number: ELK-ELK3247.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human PXR. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human PXR. Next,...
| Keywords: | SXR, PXR, NR1I2, Pregnane X receptor, Orphan nuclear receptor PXR, Orphan nuclear receptor PAR1, Steroid and xenobiotic... |
| Application: | ELISA |
| Species reactivity: | human |
From 365.00€
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12-keto Lithocholic Acid
Item number: Cay29547-5
12-keto Lithocholic acid is a metabolite of the secondary bile acid deoxycholic acid (DCA, Cay-20756, Cay-18231). Fecal levels of 12-keto lithocholic acid are elevated in rats fed a diet supplemented with cholic acid (Cay-20250) or DCA compared with rats fed a control diet or a diet supplemented with cholesterol...
| Keywords: | 12-keto-LCA, 12-Oxolithocholic Acid, (3alpha,5beta)-3-hydroxy-12-oxo-cholan-24-oic acid |
| Application: | DCA metabolite, Human pregnane X receptor agonist |
| CAS | 5130-29-0 |
| MW: | 390.6 D |
From 105.00€
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Pregnenolone Carbonitrile
Item number: Cay16343-25
Pregnenolone carbonitrile (PCN) is a catatoxic steroid that acts as an agonist of the rodent pregnane X receptor (PXR) at µM concentrations. It has been shown to mediate induction of hepatic cytochrome P450 3A, organic anion transporting peptide-2, and cholesterol 7alpha-hydroxylase, regulating both xenobiotic and...
| Keywords: | PCN, Pregnenolone 16alpha-carbonitrile, SC-4674, 3beta-hydroxy-20-oxo-pregn-5-ene-16alpha-carbonitrile |
| Application: | Rodent pregnane X receptor (PXR) agonist |
| CAS | 1434-54-4 |
| MW: | 341.5 D |
From 54.00€
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PXR (human) Reporter Assay Kit
Item number: IB-IB07001-32
Protein function: Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the...
| Keywords: | SXR, PXR, NR1I2, Pregnane X receptor, Orphan nuclear receptor PXR, Orphan nuclear receptor PAR1, Steroid and xenobiotic... |
| Application: | Functional activity screening |
| Species reactivity: | human |
From 1,448.00€
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