49 products were found matching "K08540"!
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Desmethyl Bosentan
Item number: TGM-T37351-1mg
Description: Desmethyl bosentan, an active metabolite of the endothelin receptor antagonist bosentan, activates the pregnane X receptor (PXR) in CV-1 monkey kidney cells expressing the human receptor in a reporter assay at a concentration of 25 µM. Target: Others. Smiles:...
| Application: | Bosentan active metabolite |
| CAS | 253688-61-8 |
| MW: | 537.59 D |
From 295.00€
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Specific PXR antagonist 70
Item number: TGM-T41255-100mg
Description: Specific PXR antagonist 70 is a selective pregnane X receptor (PXR) antagonist with an IC50 of 540 nM and Ki of 390 nM for human PCR and enhances the chemosensitivity of cancer cells. Target: Others. Smiles: COC1=CC=C(OC)C(=C1)N1N=NC(=C1C)S(=O)(=O)C1=CC=C(C=C1)C(C)(C)C. References: Chai SC, Lin W, Li Y,...
| Application: | PXR antagonist |
| CAS | 931314-31-7 |
| MW: | 415.51 D |
From 48.00€
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beta-Acids colupulone
Item number: TGM-T80696-1mg
Description: Colupulone, a bitter beta-acid, can be isolated from hops [1]. Smiles: O=C(C=1C(O)=C(C(=O)C(C1O)(CC=C(C)C)CC=C(C)C)CC=C(C)C)C(C)C
| Application: | Bioactive hop beta-acid |
| CAS | 468-27-9 |
| MW: | 400.55 D |
From 337.00€
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NR1I2 Protein, Human, Recombinant (His & Myc & SUMO)
Item number: TGM-TMPH-01793-100ug
Description: NR1I2 Protein, Human, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 69.8 kDa and the accession number is O75469.
| Keywords: | Pregnane X receptor, Nuclear receptor subfamily 1 group I member 2, Orphan nuclear receptor PAR1, Steroid and xenobiotic... |
| MW: | 69.8 kD |
From 198.00€
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12-Ketodeoxycholic acid
Item number: TGM-T14002-100mg
Description: 12-Ketodeoxycholic acid, a bile acid and kidney metabolite, serves as a detectable marker for kidney injury [1]. Target: Endogenous Metabolite. Smiles: C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@H](O)CC[C@]4(C)[C@H]3CC(=O)[C@]12C. References: Chen H, et al. Metabolomics insights into activated redox...
| Application: | DCA metabolite, human pregnane X receptor agonist |
| CAS | 5130-29-0 |
| MW: | 390.56 D |
From 57.00€
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Nuclear receptor subfamily 1 group I member 2 (NR1I2),...
Item number: CSB-EP016048HU.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 1-434aa. Protein Length: Full Length. Tag Info: N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged. Target Protein Sequence: MEVRPKESWN HADFVHCEDT ESVPGKPSVN ADEEVGGPQI CRVCGDKATG YHFNVMTCEG CKGFFRRAMK RNARLRCPFR KGACEITRKT RRQCQACRLR KCLESGMKKE...
| Keywords: | PXR, SXR, NR1I2, Pregnane X receptor, Orphan nuclear receptor PXR, Orphan nuclear receptor PAR1, Steroid and xenobiotic... |
| Application: | Activity not tested |
| Expressed in: | E.coli |
| Origin: | human |
| MW: | 69.8 kD |
From 219.00€
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12-keto Lithocholic Acid
Item number: Cay29547-5
12-keto Lithocholic acid is a metabolite of the secondary bile acid deoxycholic acid (DCA, Cay-20756, Cay-18231). Fecal levels of 12-keto lithocholic acid are elevated in rats fed a diet supplemented with cholic acid (Cay-20250) or DCA compared with rats fed a control diet or a diet supplemented with cholesterol...
| Keywords: | 12-keto-LCA, 12-Oxolithocholic Acid, (3alpha,5beta)-3-hydroxy-12-oxo-cholan-24-oic acid |
| Application: | DCA metabolite, human pregnane X receptor agonist |
| CAS | 5130-29-0 |
| MW: | 390.6 D |
From 107.00€
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Pregnenolone Carbonitrile
Item number: Cay16343-25
Pregnenolone carbonitrile (PCN) is a catatoxic steroid that acts as an agonist of the rodent pregnane X receptor (PXR) at µM concentrations. It has been shown to mediate induction of hepatic cytochrome P450 3A, organic anion transporting peptide-2, and cholesterol 7alpha-hydroxylase, regulating both xenobiotic and...
| Keywords: | PCN, Pregnenolone 16alpha-carbonitrile, SC-4674, 3beta-hydroxy-20-oxo-pregn-5-ene-16alpha-carbonitrile |
| Application: | Rodent pregnane X receptor (PXR) agonist |
| CAS | 1434-54-4 |
| MW: | 341.5 D |
From 55.00€
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PXR (human) Reporter Assay Kit
Item number: IB-IB07001-32
Protein function: Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the...
| Keywords: | SXR, PXR, NR1I2, Pregnane X receptor, Orphan nuclear receptor PXR, Orphan nuclear receptor PAR1, Steroid and xenobiotic... |
| Application: | Functional activity screening |
| Species reactivity: | human |
From 1,507.00€
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Trabectedin
Item number: Cay34662-1
Trabectedin is an alkaloid that has been found in E. turbinata and has anticancer activity. It is a guanine-specific DNA alkylating agent and an antagonist of the pregnane X receptor (PXR, IC50 = ~3 nM in a reporter assay). Trabectedin reduces viability of DU145 and PC3 human prostate cancer stem cells in a...
| Keywords: | Ecteinascidin 743, ET-743, NSC 648766,... |
| Application: | Alkaloid, anticancer agent, PXT antagonist, guanine-specific DNA alkylating agent |
| CAS | 114899-77-3 |
| MW: | 761.8 D |
From 264.00€
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Anti-PXR, Internal
Item number: ARG64848.100
Protein function: Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the...
| Keywords: | Anti-PXR, Anti-SXR, Anti-NR1I2, Anti-Pregnane X receptor, Anti-Orphan nuclear receptor PXR, Anti-Orphan nuclear receptor... |
| Application: | ELISA, WB |
| Host: | Goat |
| Species reactivity: | human |
822.00€
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Human PXR / NR1I2 ELISA Kit
Item number: G-HUFI00939.96
| Application: | ELISA |
| Species reactivity: | human |
641.00€
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