49 products were found matching "K08529"!

Description: CD437 (AHPN) is a specifc Retinoic Acid Receptor gamma (RARgamma) agonist. Target: Autophagy, Retinoid Receptor. Smiles: OC(=O)c1ccc2cc(ccc2c1)-c1ccc(O)c(c1)C12CC3CC(CC(C3)C1)C2. References: Li Y, et al. Molecular determinants of AHPN (CD437)-induced growth arrest and apoptosis in human lung cancer...

Description: Trifarotene (CD5789) is a potent and selective RARgamma agonist, exhibiting 65-fold and 16-fold selectivity for RARgamma (EC50=7.7 nM) over RARalpha (EC50=500 nM) and RARbeta (EC50=125 nM). Target: Retinoid Receptor, Autophagy. Smiles: CC(C)(C)c1cc(ccc1N1CCCC1)-c1cc(ccc1OCCO)-c1ccc(cc1)C(O)=O....

Description: CD 1530 is a selective and potent RARgamma agonist (Kd:150 nM) with potential anticancer activity, shows insecticidal activity against Cryptobacterium hidradii nematodes, and can be used to study oral carcinogenesis. Target: Retinoid Receptor. Smiles:...

Description: BMS270394 is a RARgamma agonist used in the study of breast cancer and dermatologic diseases. Target: Retinoid Receptor. Smiles: CC1(C)C=2C(=CC=C([C@H](C(NC3=C(F)C=C(C(O)=O)C=C3)=O)O)C2)C(C)(C)CC1. References: Klaholz BP, et al. Enantiomer discrimination illustrated by high-resolution crystal structures...

This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the human retinoic acid receptor gamma (NR1B3), a ligand-dependent transcription factor commonly referred to as RARG or RARgamma. INDIGO's reporter cells include the luciferase...

CD437 is the prototypical adamantyl arotinoid of the retinoid-related molecule family that acts as a selective agonist of retinoic acid receptor (RAR)gamma (Kds = 6.5 µM, 2.5 µM, and 77 nM for RARalpha, beta, and gamma, respectively). CD437 is cytotoxic to the acute myeloid leukemia cell line NB4 (EC50 = 0.17 µM),...

The RAR gamma Reporter (Luc)-HEK293 cell line is designed for monitoring the activity of RARgamma. The RAR gamma Reporter (Luc)-HEK293 cell line contains a firefly luciferase gene under the control of retinoic acid response elements stably integrated into HEK293 cells along with full length human RARgamma (accession...

Fenretinide is a synthetic derivative of retinoic acid (Cay-11017) and an inhibitor of dihydroceramide desaturase (IC50 = 2.32 µM). It promotes the generation of reactive oxygen species (ROS), the degradation of anti-apoptotic MCL-1, and the cleavage of pro-apoptotic PKCdelta. At 5-20 µM, fenretinide selectively...

CD2665 is a selective retinoic acid receptor (RAR)beta and RARgamma antagonist (Kds = 110, 306, and > 2,250 nM for RARgamma, RARbeta, and RARalpha, respectively, with no binding at RXRalpha). At 10-7 M, it has been used to abrogate retinoic acid (Cay-11017)-induced antiproliferative and antidifferentiative effects...

Etretinate is a second-generation retinoid previously used systemically to manage psoriasis but withdrawn due to teratogenicity. Etretinate alters cAMP signaling, which may be defective in psoriasis.Formal Name: (2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid, ethyl ester....

CD1530 is a selective retinoic acid receptor (RARgamma) agonist (Kds = 150, 1,500, and 2,750 nM for RARgamma, RARbeta, and RARalpha receptors, respectively). It demonstrates transcriptional activity at RARgamma with an AC50 value of 1.8 nM. It has been used in combination with bexarotene (Cay-11571), a retinoid X...

MM-11253 is a synthetic, conformationally restricted retinoid that acts as a selective antagonist of retinoic acid receptor gamma (RARgamma). It dose-dependently blocks the ability of RARgamma-selective agonists, but not retinoic acid (all-trans retinoic acid, Cay-11017), to inhibit the growth of oral squamous cell...