28 products were found matching "K08525"!

Description: LG100268 is an effective and selective rexinoid and retinoid-X receptor agonist. LG100268 binds to the alpha, beta, and gamma RXR receptors (IC50 = 3-4 nM). Target: Others. Smiles: CC1=C(C2(CC2)C3=CC=C(C(O)=O)C=N3)C=C4C(=C1)C(C)(C)CCC4(C)C. References: Cao M, Royce DB, Risingsong R, Williams CR, Sporn...

HX 531 is an antagonist of the retinoid X receptor (RXR) with an IC50 value of 18 nM that inhibits 9-cis retinoic acid (Cay-14587)-induced transactivation of RXR. It has been shown to reduce triglyceride content in white adipose tissue, skeletal muscle, and the liver of mice on a high fat diet.Formal Name:...

This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the human retinoid X receptor beta (NR2B2), a ligand-dependent transcription factor commonly referred to as RXRB or RXRbeta. INDIGO's reporter cells include the luciferase reporter...

UVI3003 is a full antagonist of RXR that demonstrates potent, nanomolar binding affinity. At 1 µM, UVI3003 does not affect the corepressor interaction capacity of the RARalpha subunit in the RAR-RXR heterodimer configuration. This compound can be used to isolate the contribution of RXR to the function of RXR...

LG 100754 is a ligand of retinoid X receptor (RXR) that modulates the activity of RXR dimers. It acts as an antagonist towards RXR homodimers but as an agonist of heterodimers consisting of RXR and retinoic acid receptor (RAR) or PPARs. LG 100754, at 1 µM, is a weak agonist of RXR-PPARgamma but strongly enhances...

LG 100268 is an agonist of retinoid X receptors (RXRs, Kd = 3 nM). It is selective for RXRs over retinoic acid receptors (RARs, Kd = >10,000 nM). In vitro, LG 100268 (1 µM) induces apoptosis in HL-60 human leukemia cells when used in combination with TTNPB (Cay-16144). LG 100268 (100, 300, and 1,000 nM)...

A vitamin A analog that inhibits cell proliferation and induces cell differentiation.

Tazarotene is a retinoid prodrug of tazarotenic acid (Cay-21367). It is metabolized by esterases in vivo to its active free acid form. Tazarotene (1 µM) inhibits proliferation of and collagen synthesis by human dermal fibroblasts in vitro. It also downregulates markers of keratinocyte differentiation, keratinocyte...

Protein function: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response...

This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the human retinoid X receptor beta (NR2B2), a ligand-dependent transcription factor commonly referred to as RXRB or RXRbeta. INDIGO's reporter cells include the luciferase reporter...