41 products were found matching "K08524"!

BMS 649 is a synthetic retinoid and retinoid X receptor (RXR) agonist. It binds to RXRalpha homodimers and selectively induces transactivation in CV-1 cells expressing RXRalpha over CV-1 cells expressing retinoic acid receptor alpha (RARalpha), RARbeta, or RARalpha and RXRalpha when used at a concentration of 0.1...

Description: V-125 is an agonist of retinoid X receptors. Target: Others. Smiles: CC1(C)C=2C(=CC(C)=C(N(CC)C3=CC=C(C(O)=O)C=N3)C2)C(C)(C)CC1

Description: UVI 3003 is a highly selective antagonist of the retinoid X receptor, inhibiting Xenopus and human RXRalpha in Cos7 cells with IC50 values of 0.22 µM and 0.24 µM, respectively. Target: Retinoid Receptor, Autophagy. Smiles: CCCCCOc1cc2c(cc1-c1cc(\C=C\C(O)=O)ccc1O)C(C)(C)CCC2(C)C. References: Zhu J, et...

Description: CD3254 is a selective and potent retinoid X receptor-like (RXR) agonist that inhibits neuronal cell death with OGD/reoxygenation. Target: Retinoid Receptor. Smiles: Cc1cc2c(cc1-c1cc(\C=C/C(O)=O)ccc1O)C(C)(C)CCC2(C)C. References: Nahoum V, et al. Modulators of the structural dynamics of the retinoid X...

CD3254 is a selective agonist of the retinoid X receptors (RXRs, EC50 = ~10 nM for human RXRbeta) that is without effect on retinoic acid receptors (RARs). It stimulates the recruitment of the nuclear receptor interaction domain of the TRAP220 coactivator to RXRalpha/RARbeta heterodimers in vitro. CD3254 also...

This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the human retinoid X receptor alpha (NR2B1), a ligand-dependent transcription factor commonly referred to as RXRA or RXRalpha. INDIGO's reporter cells include the luciferase reporter...

HX 531 is an antagonist of the retinoid X receptor (RXR) with an IC50 value of 18 nM that inhibits 9-cis retinoic acid (Cay-14587)-induced transactivation of RXR. It has been shown to reduce triglyceride content in white adipose tissue, skeletal muscle, and the liver of mice on a high fat diet.Formal Name:...

A vitamin A analog that inhibits cell proliferation and induces cell differentiation.

all-trans Retinoic acid is a metabolite of vitamin A and a ligand for retinoic acid receptors (RARs) with IC50 values of 9, 3, and 10 nM for RARalpha, RARbeta, and RARgamma, respectively, in radioligand binding assays. It induces expression of a luciferase reporter in COS-7 cells expressing RARalpha, RARbeta, or...

Protein function: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response...

This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the human retinoid X receptor alpha (NR2B1), a ligand-dependent transcription factor commonly referred to as RXRA or RXRalpha. INDIGO's reporter cells include the luciferase reporter...