27 products were found matching "K08424"!

Description: AS1269574 (AS 1269574) is a potent, orally available GPR119 agonist with potential for type 2 diabetes research. Target: TRP/TRPV Channel, GPR. Smiles: Cc1cc(NCCO)nc(n1)-c1ccc(Br)cc1. References: Yoshida S, et al. Identification of a novel GPR119 agonist, AS1269574, with in vitro and in vivo...

Description: APD668 is a potent GPR119 agonist with EC50 of 2.7 nM and 33 nM for hGPR119 and ratGPR119, respectively. Target: GPR, Potassium Channel, P450. Smiles: CC(C)OC(=O)N1CCC(CC1)Oc1ncnc2n(ncc12)-c1ccc(cc1F)S(C)(=O)=O. References: Semple G, et al. Bioorg Med Chem Lett. 2011 May 15,21(10):3134-41.

Description: APD597 (JNJ-38431055) is a GPR119 agonist, used in the treatment of type 2 diabetes. Target: GPR. Smiles: COc1c(Nc2ccc(nc2C)S(C)(=O)=O)ncnc1OC1CCN(CC1)C(=O)OC(C)C. References: Buzard DJ, et al. Bioorg Med Chem Lett. 2014 Sep 1,24(17):4332-5.

Description: 2-Oleoylglycerol is a lipid found in palm kernel, sunflower seed and rice bran.2-Oleoylglycerol acts as a GPR119 agonist with neuroprotective effects and induces secretion of glucagon-like peptide 1 (GLP-1).2-Oleoylglycerol is used in the modelling of non-alcoholic steatohepatitis. Target: GPR. Smiles:...

Description: AR 231453 is a selective and orally available GPR119 agonist,can stimulate beta-cell replication and improve islet graft function. Target: GPR. Smiles: N(=O)(=O)C=1C(=NC=NC1NC2=C(F)C=C(S(C)(=O)=O)C=C2)N3CCC(CC3)C4=NC(C(C)C)=NO4. References: Chu ZL, et al. A role for intestinal endocrine cell-expressed g...

Description: MBX-2982 is a selective, orally available GPR119 agonist used in the treatment of diabetes. Target: GPR. Smiles: CCc1cnc(nc1)N1CCC(CC1)c1ncc(COc2ccc(cc2)-n2cnnn2)s1. References: Hothersall JD, et al. Sustained wash-resistant receptor activation responses of GPR119 agonists. Eur J Pharmacol. 2015 Sep...

2-Oleoyl glycerol (2-OG) is a natural monoacylglycerol with an 18:1 oleoyl group at the sn-2 position of glycerol. 2-OG, like 2-arachidonoyl glycerol (2-AG, Cay-62160), is metabolized by monoacylglycerol lipase, but, unlike 2-AG, it is not metabolized by cyclooxygenases or lipoxygenases. 2-OG is an agonist of GPR119...

Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...

MBX-2982 is an agonist of GPR119. It reduces nuclear and total protein levels of sterol regulatory element binding protein 1 (SREBP-1) in HepG2 cells and rat primary hepatocytes under high-glucose and -insulin conditions and increases phosphorylation of the inhibitory form, SREBP-1c. MBX-2982 (10 mg/kg) inhibits...

GPR119 (previously designated SNORF25) is an orphan G protein-coupled receptor expressed predominantly in the pancreas and gastrointestinal tract in humans and in the brain, pancreas, and gastrointestinal tract in rodents. It mediates a reduction in food intake and body weight gain in rats upon treatment with oleoyl...

Oleoyl serinol is an analog of ceramide and an agonist of the cannabinoid receptor GPR119 that has an EC50 value of 12 µM for stimulating secretion of GLP-1 in mouse endocrine GLUTag cells. It has been found in E. coli that express human microbiota N-acyl synthase (hmNAS) genes. It induces cell death of F-11 murine...

GPR119, a glucose-dependent insulinotropic receptor, is a G protein-coupled receptor that is expressed in pancreatic beta-cells and intestinal L-cells. Activation of GPR119 by the endogenous ligands lyso-phosphatidylcholine (Cay-10172) and oleoyl ethanolamide (Cay-90265) increases intracellular cAMP levels and...