41 products were found matching "K08400"!
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3-Oxo-5beta-cholanoic acid
Item number: TGM-T13502-10mg
Description: 3-Oxo-5beta-cholanoic acid (Dehydrolithocholic acid) is a bile acid metabolite that inhibits TH17 cell differentiation by directly binding to the transcription factor RORgammat with a Kd of 1.13 µM. Target: ROR. Smiles: C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C....
| Keywords: | Dehydrolithocholic acid |
| Application: | Major lithocholic acid metabolite, TGR5 / VDR / FXR agonist |
| CAS | 1553-56-6 |
| MW: | 374.56 D |
From 41.00€
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SB756050
Item number: TGM-T4352-100mg
Description: SB756050 is a specific TGR5 agonist. Target: GPCR19. Smiles: COc1ccc(cc1OC)S(=O)(=O)N1CCCN(CC1)S(=O)(=O)c1ccc(OC)c(OC)c1. References: Hodge RJ, et al. Safety, Pharmacokinetics, and Pharmacodynamic Effects of a Selective TGR5 Agonist, SB-756050, in Type 2 Diabetes. Clin Pharmacol Drug Dev. 2013...
| Keywords: | SB-756050, SB 756050 |
| Application: | TGR5 agonist |
| CAS | 447410-57-3 |
| MW: | 500.59 D |
From 35.00€
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BAR501
Item number: TGM-T4083-100mg
Description: BAR501 is an effective and specific GPBAR1 agonist (EC50: 1 µM). Target: GPCR19. Smiles: CC[C@@H]1[C@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)CCCO)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12. References: Renga B, et al. Reversal of Endothelial Dysfunction by GPBAR1 Agonism in Portal Hypertension Involves a...
| Keywords: | BAR 501 |
| Application: | Selective GPBAR1 agonist |
| CAS | 1632118-69-4 |
| MW: | 406.64 D |
From 56.00€
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SBI-115
Item number: TGM-T7428-100mg
Description: SBI-115 is an antagonist of TGR5. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5. Target: GPCR19. Smiles: CCS(=O)(=O)c1ncc(Cl)c(n1)C(=O)Oc1cccc(C)c1. References: Masyuk TV, Masyuk AI, Lorenzo Pisarello M,et al.TGR5 contributes to hepatic cystogenesis in rodents...
| Application: | GPBAR1 antagonist |
| CAS | 882366-16-7 |
| MW: | 340.78 D |
From 48.00€
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BAR 501 impurity
Item number: TGM-T8752-10mg
Description: BAR501 impurity is an impurity found in the preparation of BAR501 that acts as an agonist of the G protein-coupled bile acid-activated receptor (GP-BAR1). BAR501 impurity (10 µM) induces a 150% increase in luciferase activity in a GP-BAR1 reporter gene assay. Target: GPCR19. Smiles:...
| Application: | Control |
| CAS | 1632118-70-7 |
| MW: | 406.64 D |
From 130.00€
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BAR502
Item number: TGM-TQ0252-100mg
Description: BAR502 is a dual GPBAR1 and FXR agonist (IC50s: 0.4 µM and 2 µM). Target: Autophagy, FXR, GPCR19. Smiles: CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)CCO)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12. References: Festa C, et al. Exploitation of cholane scaffold for the discovery of potent and...
| Application: | GPBAR1 /FXR dual agonist |
| CAS | 1612191-86-2 |
| MW: | 392.62 D |
From 105.00€
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TGR5 Receptor Agonist
Item number: TGM-T1824-100mg
Description: TGR5 is a potent TGR5(GPCR19) agonist. Target: GPCR19. Smiles: CN(C(=O)c1c(C)onc1-c1ccccc1Cl)c1ccc(Cl)cc1. References: Evans KA, et al. J Med Chem. 2009 Dec 24,52(24): 7962-5.
| Application: | GPBAR1 agonist |
| CAS | 1197300-24-5 |
| MW: | 361.22 D |
From 34.00€
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G-protein coupled bile acid receptor 1 (GPBAR1), human,...
Item number: CSB-CF819471HU.100
Organism: Homo sapiens (Human). Source: in vitro E.coli expression system. Expression Region: 1-330aa. Protein Length: Full Length. Tag Info: N-terminal 10xHis-tagged. Target Protein Sequence: MTPNSTGEVP SPIPKGALGL SLALASLIIT ANLLLALGIA WDRRLRSPPA GCFFLSLLLA GLLTGLALPT LPGLWNQSRR GYWSCLLVYL APNFSFLSLL ANLLLVHGER...
| Keywords: | BG37, TGR5, M-BAR, hBG37, GPBAR1, hGPCR19, G-protein coupled receptor GPCR19, Membrane-type receptor for bile acids,... |
| Application: | Activity not tested |
| Expressed in: | E.coli in vitro |
| Origin: | human |
| MW: | 36.8 kD |
From 1,413.00€
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G-protein coupled bile acid receptor 1 (GPBAR1), partial,...
Item number: CSB-EP819471HU1.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 283-330aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-KSI-tagged. Target Protein Sequence: GDQRYTAPWR AAAQRCLQGL WGRASRDSPG PSIAYHPSSQ SSVDLDLN. Purity: Greater than 85% as determined by SDS-PAGE. Endotoxin: Not test. Biological Activity:...
| Keywords: | BG37, TGR5, M-BAR, hBG37, GPBAR1, hGPCR19, G-protein coupled receptor GPCR19, Membrane-type receptor for bile acids,... |
| Application: | Activity not tested |
| Expressed in: | E.coli |
| Origin: | human |
| MW: | 20.6 kD |
From 283.00€
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Human GPBAR1 Protein, hFc Tag
Item number: DIM-PME101519.10
Recombinant human GPBAR1 Protein with C-terminal human Fc tag. GPBAR1(Met1-Gly19) hFc(Glu99-Ala330), Protein function: Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of...
| Keywords: | BG37, TGR5, M-BAR, GPCR19, GPR131 |
| Expressed in: | Human cells |
| Origin: | human |
| CAS | 12 |
| MW: | 28.0 kD |
From 126.00€
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INT-777
Item number: Cay17678-500
TGR5 is a transmembrane G protein-coupled receptor that is activated by bile acid. INT-777 is a semisynthetic bile acid that acts as an agonist of TGR5 (EC50 = 0.82 µM). It is active in vivo, stimulating the secretion of glucagon-like peptide 1 (GLP-1) in mice when given orally (30 mg/kg) after a glucose challenge,...
| Keywords: | HY-15677, 6-EMCA, S-EMCA, (3alpha,5beta,6alpha,7alpha,12alpha,23S)-6-ethyl-3,7,12-trihydroxy-cholane-23-carboxylic acid |
| Application: | TGR5 agonist |
| CAS | 1199796-29-6 |
| MW: | 450.7 D |
From 163.00€
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SBI-115
Item number: Cay39168-10
SBI-115 is an antagonist of G protein-coupled bile acid receptor 1 (GPBAR1), also known as TGR5. It inhibits taurolithocholic acid-induced increases in cAMP levels in, and proliferation of, cholangiocytes isolated from patients with autosomal dominant polycystic kidney disease when used at concentrations of 100 and...
| Keywords: | 5-chloro-2-(ethylsulfonyl)-4-pyrimidinecarboxylic acid 3-methylphenyl ester |
| Application: | GPBAR1 antagonist |
| CAS | 882366-16-7 |
| MW: | 340.8 D |
From 74.00€
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