166 products were found matching "K08268"!
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Anti-HIF-1alpha (C-Term)
Item number: Cay10006421-1
Hypoxia-inducible factor-1alpha (HIF-1alpha) is a transcription factor that accumulates under low-oxygen conditions. Following hypoxic stimulus and cytoplasmic accumulation, HIF-1alpha migrates to the nucleus where with other transcription factors, it drives the production of stress-adaptive proteins. This response...
| Keywords: | Anti-BHLHE78, Anti-bHLHe78, Anti-bHLHe78, Anti-ARNT-interacting protein, Anti-ARNT-interacting protein, Anti-PAS... |
| Application: | IHC, WB |
| Host: | Rabbit |
| Species reactivity: | human, mouse |
431.00€
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SYP-5
Item number: TGM-T13050-100mg
Description: SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis. Target: HIF/HIF Prolyl-Hydroxylase, HIF. Smiles: CC1(C)Oc2ccc(C(=O)\C=C\c3cccs3)c(O)c2C=C1. References: Wang LH, et al. SYP-5, a novel HIF-1 inhibitor, suppresses tumor cells invasion and angiogenesis. Eur J...
| Application: | HIF-1alpha inhibitor |
| CAS | 1384268-04-5 |
| MW: | 312.38 D |
From 38.00€
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Echinomycin
Item number: TGM-T15197-1mg
Description: Echinomycin is a cell-permeable hypoxia-inducible factor-1 (HIF-1) DNA-binding activity inhibitor. Echinomycin selectively inhibits the cancer stem cells (CSCs, IC50: 29.4 pM). Target: Others. Smiles:...
| Keywords: | Quinomycin A, NSC-13502 |
| Application: | Apoptosis inducer |
| CAS | 512-64-1 |
| MW: | 1101.26 D |
From 237.00€
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GN44028
Item number: TGM-T15396-100mg
Description: GN44028 (N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine) is a hypoxia-inducible factor inhibitor of (HIF)-1 (IC50: 14 nM). GN44028 inhibits hypoxia-induced HIF-1alpha transcriptional activity. However, It can not be suppressing HIF-1alpha mRNA expression, HIF-1alpha protein...
| Keywords: | N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine |
| Application: | HIF-1alpha transcriptional activity inhibitor |
| CAS | 1421448-26-1 |
| MW: | 305.33 D |
From 105.00€
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LW6
Item number: TGM-T3494-100mg
Description: LW6 (HIF-1alpha inhibitor) is a novel HIF-1 inhibitor. Target: HIF/HIF Prolyl-Hydroxylase, HIF, Apoptosis, Dehydrogenase. Smiles: COC(=O)c1ccc(O)c(NC(=O)COc2ccc(cc2)C2C3CC4CC(C3)CC2C4)c1. References: Naik R , Won M , Ban H S , et al. Synthesis and Structure-Activity Relationship Study of Chemical...
| Keywords: | LW8, CAY10585, HIF-1alpha inhibitor |
| Application: | HIF-1alpha accumulation inhibition |
| CAS | 934593-90-5 |
| MW: | 435.51 D |
From 39.00€
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Amifostine
Item number: TGM-T3289-100mg
Description: Amifostine (Ethyol) anhydrous is a cytoprotective agent, acts as a free radical scavenging activity. Target: HIF/HIF Prolyl-Hydroxylase, Others. Smiles: NCCCNCCSP(O)(O)=O. References: Kouvaris JR. Oncologist. 12 (6): 738-47
| Keywords: | Gammaphos, WR2721, Ethyol |
| Application: | Chemopreventive agent |
| CAS | 20537-88-6 |
| MW: | 214.22 D |
From 32.00€
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HIF-1alpha inhibitor-1
Item number: TGM-T71661-100mg
Description: HIF-1alpha inhibitor-1 is a HIF-1 alpha inhibitor. Target: Others. Smiles: OC1=CC(=CN=C1C(NCC(O)=O)=O)C2=CC=C(C#N)C=C2
| Application: | HIF-1alpha inhibitor |
| CAS | 1000025-14-8 |
| MW: | 297.27 D |
From 1,491.00€
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Vitexin
Item number: TGM-T6S1369-100mg
Description: 1. Vitexin has antinociceptive and antispasmodic activities. 2. Vitexin exhibits a prominent first-pass effect. 3. Vitexin has antioxidant, antimyeloperoxidase, and alpha-glucosidase inhibitory activities. 4. Vitexin can either inhibit or induce activities of CYP2C11 and CYP3A1. 5. Vitexin induces the...
| Keywords: | Apigenin-8-C-glucoside |
| Application: | alpha-Glucosidase inhibitor, Antioxidant, HIF-1 alpha inhibitor |
| CAS | 3681-93-4 |
| MW: | 432.38 D |
From 47.00€
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PX-478
Item number: TGM-T6961-100mg
Description: PX-478 is a HIF-1alpha inhibitor with selectivity, oral activity, and blood-brain barrier permeability. PX-478 has antitumor activity and also protects pancreatic beta-cell function in diabetes mellitus and is used in type 2 diabetes mellitus research. Target: HIF, Autophagy, HIF/HIF...
| Keywords: | PX-478 2HCl |
| Application: | HIF-1 alpha inhibitor |
| CAS | 685898-44-6 |
| MW: | 394.12 D |
From 48.00€
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ML228
Item number: TGM-T7836-100mg
Description: ML228 is a potent the Hypoxia Inducible Factor (HIF) pathway activator with EC50 of 1 µM. ML228 potently activates HIF in vitro as well as its downstream target VEGF. Target: HIF. Smiles: C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)c1ccc(cc1)-c1ccccc1. References: Theriault JR, et al. Discovery of a Small Molecule...
| Application: | HIF signaling pathway activator |
| CAS | 1357171-62-0 |
| MW: | 415.49 D |
From 37.00€
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HIF-1 alpha Protein, Human, Recombinant (His)
Item number: TGM-TMPY-01709-100ug
Description: HIF-1 alpha, also known as HIF1A, contains 1 basic helix-loop-helix (bHLH) domain, 1 PAC (PAS-associated C-terminal) domain, and 2 PAS (PER-ARNT-SIM) domains. It is one of the two subunits of Hypoxia-inducible factor-1 (HIF1). HIF1 is a transcription factor found in mammalian cells cultured under...
| Keywords: | HIF1-ALPHA, HIF1-alpha, HIF1, hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor),... |
| MW: | 28.4 kD |
686.00€
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HIF-1 inhibitor-4
Item number: TGM-T67767-100mg
Description: HIF-1 inhibitor-4 (HIF-1 inhibitor-4) is a HIF-1 inhibitor with IC50 of 560 nM. HIF-1 inhibitor-4 reduces the HIF-1alpha protein level without affecting its mRNA level. Target: HIF. Smiles: IC1=CC=C(NC(=O)C2=CC=C(CN3CCOCC3)C=C2)C=C1. References: Nagao S, et al. Synthesis and structure-activity...
| Keywords: | HIF-1 inhibitor-4 |
| Application: | HIF-1 inhibitor |
| CAS | 333357-56-5 |
| MW: | 422.26 D |
From 41.00€
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