23 products were found matching "K08208"!

Description: Verinurad (RDEA3170) (RDEA3170) is an organic anion transporter URAT1 (SLC22A12) inhibitor for the treatment of gout and hyperuricemia. Target: OAT. Smiles: CC(C)(Sc1ccncc1-c1ccc(C#N)c2ccccc12)C(O)=O. References: Diaz-Torné C, Perez-Herrero N, Perez-Ruiz F. New medications in development for the...

Description: URAT1 Inhibitor 4, derived from Lesinurad, is a potent, orally active inhibitor of URAT1 with an IC50 value of 7.56 µM, demonstrating greater in vivo urate-lowering efficacy than Lesinurad [1]. Target: Others. Smiles: S(CC(NS(=O)(=O)C1=CC=C(Br)C=C1)=O)C=2N(C(=O)C3=C(N2)SC=C3)C=4C5=C(C(=CC4)C6CC6)C=CC=C5

Description: URAT1 inhibitor 7 is a novel and potent inhibitor of the human uric acid transporter protein URAT1 (IC50:12 nM).URAT1 inhibitor 7 inhibits CYP2C9 with an IC50 of 4.2 µM.URAT1 inhibitor 7 can be used to study hyperuricemia and gout. Target: OAT. Smiles:...

Description: URAT1 Inhibitor 8 (example 247) serves as a highly potent inhibitor of URAT1, demonstrating an IC50 value of 0.001 µM. It is applicable in the study of gout [1]. Target: Others. Smiles: N#CC1=CC(=CC=C1OC2=CC=C(C(Cl)=C2)CO)S(=O)(=O)NC3=NC=C(F)C=C3

Dotinurad is a urate transporter 1 (URAT1) antagonist (IC50 = 0.0372 µM). It is selective for URAT1 over ATP-binding cassette subfamily G member 2 (ABCG2), organic anion transporter 1 (OAT1), and OAT3 (IC50s = 4.16, 4.08, and 1.32 µM, respectively). In vivo, dotinurad (30 mg/kg) decreases plasma levels of urate and...

Description: URAT1 inhibitor 1 (1g) is a potent inhibitor of uric acid transporter 1 (URAT1) with an IC50 of 32 nM, and has potential therapeutic applications for treating hyperuricemia associated with gout. Target: OAT. Smiles: Brc1nnc(SCS(=O)(=O)Nc2cccnc2)n1Cc1ccc(Br)c2ccccc12. References: Wu JW, et al. Synthesis,...

Description: Benzbromarone (Desuric) is a CYP2C9 inhibitor with Ki value of 19.3 nM. Target: Xanthine Oxidase, Apoptosis, P450. Smiles: C(=O)(C=1C=2C(OC1CC)=CC=CC2)C3=CC(Br)=C(O)C(Br)=C3. References: Locuson CW 2nd, et al. Drug Metab Dispos, 2003, 31(7), 967-971.

Description: Benzarone (Benzarona) is a potent inhibitor of human uric acid transporter 1 (URAT1, IC50 = 2.8 µM in oocyte). Benzarone lowers the level of uric acid serum. Target: OAT. Smiles: CCc1oc2ccccc2c1C(=O)c1ccc(O)cc1. References: Kaufmann P, Török M, Hänni A, Roberts P, Gasser R, Krähenbühl S. Mechanisms of...

Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: SLC22A12. Antigen Species: Human

Lesinurad is an inhibitor of urate anion transporter 1 (URAT1, IC50s = 3.5 and 81 µM for human and rat transporters, respectively), a transporter that prevents renal urate resorption. It decreases uptake of urate by MDCK cells transfected with human URAT1. Lesinurad (80 mg/kg) also decreases serum levels of uric...

Protein function: Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions. [The UniProt Consortium]

Verinurad is an inhibitor of urate anion transporter 1 (URAT1, IC50 = 0.025 µM for the human transporter). It is selective for human URAT1 over rat URAT1 (IC50 = 41 µM), as well as human organic anion transporter 1 (OAT1) and OAT4 (IC50s = 4.6 and 5.9 µM, respectively).Formal Name:...