31 products were found matching "K08041"!

Description: Wnt pathway inhibitor 3 is a potent AC1 inhibitor (IC50: 45 nM) with antiproliferative activity, suitable for studies to ameliorate osteoarthritis in a mouse model of experimental osteoarthritis. Target: Adenylyl cyclase, Wnt/beta-catenin. Smiles:...

Description: ST034307 is an effective and selective inhibitor of adenylyl cyclase 1 (IC50: 2.3 µM). Target: Adenylyl cyclase. Smiles: Clc1ccc2oc(cc(=O)c2c1)C(Cl)(Cl)Cl. References: Brust TF, et al. Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties....

Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...

Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: ADCY1. Antigen Species: Human

Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: ADCY1. Antigen Species: Human

Isolated from Coleus forskohlii. Potent, cell permeable adenylyl cyclase activator. Increases intracellular cAMP levels. Widely used tool to investigate cAMP as a second messenger. Inotropic and antihypertensive. Smooth muscle relaxant/vasodilator. Glucose transporter inhibitor. Platelet aggregation inhibitor....

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Protein function: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca(2+)/calmodulin levels (PubMed:9662407, PubMed:7816821). May be involved in regulatory processes in the central nervous system (PubMed:9662407). May play a role in...

Forskolin is a cell permeable adenylate cyclase activator which causes an increase in the intracellular concentration of cAMP. This makes it an important hypotensive and vasodilatory agent. Forskolin also affects calcium currents and inhibits PKC (Protein Kinase C)-stimulated MAPK and RAF-1.

ST034307 is an inhibitor of adenylyl cyclase 1 (AC1), a membrane-bound AC, with an IC50 value of 2.3 µM for A23187-stimulated cAMP accumulation in HEK293 cells transfected with AC1. It also inhibits AC1 activation induced by forskolin (Cay-11018) or isoproterenol (Cay-15592) in vitro. It is selective for AC1 over...

This gene encodes a form of adenylate cyclase expressed in brain. A similar protein in mouse is involved in pattern formation of the brain. Protein function: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca(2+)/calmodulin levels....