241 products were found matching "K07827"!
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GDC-6036
Item number: Cay41852-1
GDC-6036 is a covalent inhibitor of K-Ras containing a glycine-to-cysteine substitution at position 12 (K-RasG12C). It decreases tumor volume in a PaCa-2 pancreatic cancer mouse xenograft model when administered at doses ranging from 1 to 100 mg/kg per day.Formal Name:...
| Keywords: | Divarasib, RG-6330,... |
| Application: | Covalent K-RasG12C inhibitor |
| CAS | 2417987-45-0 |
| MW: | 622.1 D |
From 136.00€
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RMC-6236
Item number: Cay41982-1
RMC-6236 is a non-covalent inhibitor of GTP-bound RAS. It binds to peptidyl-prolyl cis-trans isomerase A (PPIase A), also known as cyclophilin A (CypA, Kd = 55.3 nM) to form a binary complex that then binds to wild-type K-Ras, K-Ras(G12V), and K-Ras(G12D) (Kds = 131, 364, and 154 nM, respectively). RMC-6236 forms a...
| Keywords: | (1S,2S)-N-[(2R,14S,18S)-1-ethyl-18,19,20,21-tetrahydro-2-[2-[(1S)-1-methoxyethyl]-5-(4-methyl-1-piperazinyl)-3-pyridinyl]-... |
| Application: | Non-covalent GTP-bound Ras inhibitor |
| CAS | 2765081-21-6 |
| MW: | 811.1 D |
From 108.00€
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KRAS G12C inhibitor 13
Item number: TGM-T11767-100mg
Description: KRAS G12C Inhibitor 13 is a specific inhibitor targeting the KRAS G12C mutation. Target: Ras. Smiles: C(C=C)(=O)N1CC2(C1)CCN(CC2)C=3C4=C(C(OCC(F)(F)F)=C(C(C=C)=C4)C5=C6C(=CC=C5C)NN=C6)N=C(OC7CCN(CC7)C8CCOCC8)N3. References: KURAMOTO, Kazuyuki, et al. Quinazoline compound. WO2018143315A1.
| Application: | KRAS G12C inhibitor |
| CAS | 2241719-75-3 |
| MW: | 745.83 D |
From 2,080.00€
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KRAS G12C inhibitor 14
Item number: TGM-T11768-10mg
Description: KRAS G12C inhibitor 14 is a potent compound with an IC50 of 18 nM [1]. Target: Ras. Smiles: CN1C(=O)[C@H]2CN(CCN2c2c1cnc1c(F)c(c(Cl)cc21)-c1c(O)cccc1F)C(=O)C=C. References: Jason Grant Kettle, et al. Tetracyclic compounds as inhibitors of g12c mutant ras protein, for use as anti-cancer agents....
| Application: | KRAS G12C inhibitor |
| CAS | 2349393-95-7 |
| MW: | 484.88 D |
From 936.00€
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KRAS G12C inhibitor 15
Item number: TGM-T11769-100mg
Description: KRAS G12C inhibitor 15 is a potent inhibitor of the KRAS G12C protein. Target: Ras. Smiles: C[C@@H]1CN2[C@H](CN1C(=O)C=C)C(=O)N(C)c1cnc3c(F)c(c(Cl)cc3c21)-c1c(O)cccc1F. References: Jason Grant Kettle, et al. Tetracyclic compounds as inhibitors of g12c mutant ras protein, for use as anti-cancer agents....
| Application: | KRAS G12C inhibitor |
| CAS | 2349393-21-9 |
| MW: | 498.91 D |
From 3,121.00€
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KRAS G12C inhibitor 16
Item number: TGM-T11770-10mg
Description: KRAS G12C inhibitor 16 is a potent inhibitor of KRAS G12C. Target: Ras. Smiles: CC1=C2C(C=3N4[C@](CN(C(C=C)=O)CC4)(COC3C=N2)[H])=CC(Cl)=C1C5=C(F)C=CC=C5O. References: Jason Grant Kettle, et al. Tetracyclic compounds as inhibitors of g12c mutant ras protein, for use as anti-cancer agents. WO2019110751A1.
| Application: | KRAS G12C inhibitor |
| CAS | 2349392-79-4 |
| MW: | 453.89 D |
From 447.00€
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KRAS G12C inhibitor 17
Item number: TGM-T11771-100mg
Description: KRAS G12C inhibitor 17 is a potent inhibitor of the KRAS G12C protein. Target: Ras. Smiles: FC1=C2C(C=3N4[C@](CN(C(C=C)=O)[C@H](C)C4)(COC3C=N2)[H])=CC(Cl)=C1C5=C(F)C=CC=C5O. References: Jason Grant Kettle, et al. Tetracyclic compounds as inhibitors of g12c mutant ras protein, for use as anti-cancer...
| Application: | KRAS G12C inhibitor |
| CAS | 2349393-04-8 |
| MW: | 471.88 D |
From 1,933.00€
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KRAS inhibitor-4
Item number: TGM-T11772-25mg
Description: KRAS inhibitor-4 developed as anticancer agents, is a potent KRAS inhibitor. Target: Others. Smiles: ClC=1C(=C2C(=CC1C)NN=C2)[C@@H]3CC=4C(C[C@H]3C)=C(N=C(N4)N5CC(N(C)C)C5)N6C[C@@H](C)N(C(C=C)=O)CC6. References: CHEN, Ping, et al. TETRAHYDROQUINAZOLINE DERIVATIVES USEFUL AS ANTICANCER AGENTS. WO2019155399.
| Application: | KRAS inhibitor |
| CAS | 2374152-69-7 |
| MW: | 563.14 D |
1,943.00€
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KRAS inhibitor-6
Item number: TGM-T11773-100mg
Description: KRAS inhibitor-6 is a potent inhibitor of the KRAS G12C variant. Target: Ras. Smiles: FC=1C2=C(C(=NC(OCCN(CC)CC)=N2)N3CCN(C(C=C)=O)CC3)C=C(Cl)C1C4=C(F)C=CC=C4O. References: Liansheng Li, et al. 2-substituted quinazoline compounds comprising a substituted heterocyclic group and methods of use thereof....
| Application: | KRAS inhibitor |
| CAS | 2022986-61-2 |
| MW: | 546.01 D |
From 1,638.00€
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KRAS inhibitor-7
Item number: TGM-T11774-100mg
Description: KRAS inhibitor-7 is a potent inhibitor of KRAS G12C. (KRAS inhibitor-7 specifically targets the G12C mutation in KRAS, a protein involved in cell signaling and cancer development.) [KRAS inhibitor-7 exhibits high binding affinity and selectivity for the mutant KRAS protein.]. Target: Ras. Smiles:...
| Application: | KRAS inhibitor |
| CAS | 2022986-68-9 |
| MW: | 528.98 D |
From 1,491.00€
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KRAS inhibitor-8
Item number: TGM-T11775-100mg
Description: KRAS inhibitor-8 is a potent inhibitor of the mutated KRAS G12C protein. Target: Ras. Smiles: FC=1C2=C(C(=NC(OCCN3CC(F)(F)C3)=N2)N4CCN(C(C=C)=O)CC4)C=C(Cl)C1C5=C(F)C=CC=C5O. References: Liansheng Li, et al. 2-substituted quinazoline compounds comprising a substituted heterocyclic group and methods of...
| Application: | KRAS inhibitor |
| CAS | 2022986-70-3 |
| MW: | 565.95 D |
From 2,227.00€
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KRas G12C inhibitor 1
Item number: TGM-T11776-100mg
Description: KRas G12C inhibitor 1 is a compound that selectively inhibits the KRas G12C protein. Target: Ras. Smiles: C[C@@H]1N(C2=C3C(CN(CC3)C=4C5=C(C=C(O)C4)C=CC=C5)=NC(OC[C@H]6N(C)CCC6)=N2)CCN(C(C=C)=O)C1. References: Blake J, et al. Kras g12c inhibitors. US 20180072723 A1.
| Application: | KRas G12C inhibitor |
| CAS | 2158297-28-8 |
| MW: | 542.67 D |
From 1,638.00€
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