139 products were found matching "K07294"!
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Saroglitazar Magnesium
Item number: Cay41694-1
Saroglitazar magnesium is a dual agonist of PPARalpha and PPARgamma (EC50s = 0.65 and 3,000 pM, respectively, in a transactivation assay in HepG2 cells). It decreases serum triglyceride, free fatty acid, and glucose levels in a db/db mouse model of diabetes when administered at doses ranging from 0.01 to 3 mg/kg per...
| Keywords: | (T-4)-bis[(alphaS)-alpha-(ethoxy-kappaO)-4-[2-[2-methyl-5-[4-(methylthio)phenyl]-1H-pyrrol-1-yl]ethoxy]benzenepropanoato-k... |
| Application: | PPARalpha / PPARgamma dual agonist |
| CAS | 1639792-20-3 |
| MW: | 901.4 D |
From 48.00€
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Fenofibric acid
Item number: TGM-T1402-1g
Description: Fenofibric acid (FNF acid) is the active form of fenofibrate, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity. Target: MMP, COX, PPAR. Smiles: C(=O)(C1=CC=C(OC(C(O)=O)(C)C)C=C1)C2=CC=C(Cl)C=C2. References: Arakawa R, et al. Arterioscler Thromb Vasc Biol. 2005,...
| Keywords: | NSC 281318, Trilipix, FNF acid |
| Application: | Targets peroxisome proliferator-activated receptor alpha (NR1C1, PPARA) |
| CAS | 42017-89-0 |
| MW: | 318.75 D |
From 31.00€
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Saroglitazar
Item number: TGM-T12835-10mg
Description: Saroglitazar (Lipaglyn) is an agonist of PPAR with EC50 values of 0.65 pM and 3 nM for PPARalpha and PPARgamma. Target: PPAR. Smiles: CCO[C@@H](Cc1ccc(OCCn2c(C)ccc2-c2ccc(SC)cc2)cc1)C(O)=O. References: Jain MR, et al. Saroglitazar, a novel PPARalpha/gamma agonist with predominant PPARalpha activity,...
| Keywords: | Lipaglyn |
| Application: | PPARalpha agonist, PPARgamma agonist |
| CAS | 495399-09-2 |
| MW: | 439.57 D |
From 149.00€
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LG100754
Item number: TGM-T15748-100mg
Description: LG100754 (UVI 2112) is an insulin sensitizer that functions through RXR. LG100754 is an RXR dimer modulator. LG100754 acts as an RXR: RXR homodimer antagonist, but functions as an agonist towards RXR: PPARalpha and RXR: PPARgamma heterodimers. Target: PPAR. Smiles:...
| Keywords: | UVI 2112 |
| Application: | RXR homodimer antagonist, RXR:PPAR alpha/gamma heterodimer agonist |
| CAS | 180713-37-5 |
| MW: | 396.56 D |
From 973.00€
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Gemfibrozil
Item number: TGM-T1415-100mg
Description: Gemfibrozil (CI-719) interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. Gemfibrozil is a fibric acid derivative with hypolipidemic effects. This enhances...
| Keywords: | CI-719, Lopid, Decrelip, Jezil |
| Application: | Targets peroxisome proliferator-activated receptor alpha (NR1C1, PPARA) |
| CAS | 25812-30-0 |
| MW: | 250.33 D |
From 31.00€
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Aleglitazar
Item number: TGM-T14176-100mg
Description: Aleglitazar (R1439) (R1439) is a potent dual PPARalpha/gamma agonist, with IC50s of 38 nM and 19 nM for human PPARa and PPARgamma, respectively. Aleglitazar can be used for the research of type II diabetes. Target: PPAR. Smiles: C([C@@H](C(O)=O)OC)C1=C2C(=C(OCCC=3N=C(OC3C)C4=CC=CC=C4)C=C1)C=CS2....
| Keywords: | R1439, RO0728804 |
| Application: | Targets peroxisome proliferator-activated receptor alpha (NR1C1, PPARA) |
| CAS | 475479-34-6 |
| MW: | 437.51 D |
From 252.00€
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Aluminium clofibrate
Item number: TGM-T21243-25mg
Description: Aluminium clofibrate, a salt of clofibric acid, is a peroxisome proliferator. Target: Others. Smiles: [OH-][Al+3]12(O(C(C)(C)C(=O)[O-]1)C3=CC=C(Cl)C=C3)O(C(C)(C)C(=O)[O-]2)C4=CC=C(Cl)C=C4. References: Takagi A, Sai K, Umemura T, Hasegawa R, Kurokawa Y. Relationship between hepatic peroxisome...
| Keywords: | Alufibrate, Atherolip, Alfibrate |
| Application: | Targets peroxisome proliferator-activated receptor alpha (NR1C1, PPARA) |
| CAS | 24818-79-9 |
| MW: | 471.26 D |
1,491.00€
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LT175
Item number: TGM-T21812-1mg
Description: LT175, a dual PPARalpha/gamma ligand, demonstrates potent insulin-sensitizing effects with reduced adipogenic properties. This orally active partial agonist targets PPARgamma with EC50 values of 0.22 µm for hPPARalpha, 0.26 µm for mPPARalpha, and 0.48 µm for hPPARgamma. LT175 specifically interacts with...
| Application: | PPAR gamma / alpha partial agonist |
| CAS | 862901-87-9 |
| MW: | 318.37 D |
77.00€
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KRP-297
Item number: TGM-T27749-10mg
Description: KRP297 is a PPAR agonist potentially for the treatment of type 2 diabetes and dyslipidemia. Target: Others. Smiles: C(NCC1=CC=C(C(F)(F)F)C=C1)(=O)C2=C(OC)C=CC(CC3SC(=O)NC3=O)=C2. References: Xu XS, Yan KX, Song H, Lo MW. Quantitative determination of a novel dual PPAR alpha/gamma agonist using on-line...
| Keywords: | L 410198, L410198, MK-0767, KRP297 |
| Application: | PPARalpha / PPARgamma dual agonist |
| CAS | 213252-19-8 |
| MW: | 438.42 D |
From 179.00€
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Peliglitazar
Item number: TGM-T28354-100mg
Description: Peliglitazar is a activator of alpha/gamma peroxisome proliferator-activated receptor. Target: Others. Smiles: C(COC1=CC=C([C@@H](N(C(OC2=CC=C(OC)C=C2)=O)CC(O)=O)C)C=C1)C=3N=C(OC3C)C4=CC=CC=C4. References: Wang L, Munsick C, Chen S, Bonacorsi S, Cheng PT, Humphreys WG, Zhang D. Metabolism and...
| Keywords: | BMS 42670701, BMS 426707-01, BMS-426707-1 |
| Application: | Targets peroxisome proliferator-activated receptor alpha (NR1C1, PPARA) |
| CAS | 331744-64-0 |
| MW: | 530.57 D |
From 1,786.00€
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GW 9578
Item number: TGM-T27519-10mg
Description: GW 9578 is a selective and potent PPARalpha agonist with potent lipid-lowering activity for the study of psoriasis, arthritis, alopecia, asthma and type I diabetes. Target: PPAR. Smiles: S(C(C(O)=O)(C)C)C1=CC=C(CCN(C(NC2=C(F)C=C(F)C=C2)=O)CCCCCCC)C=C1. References: P J Brown, et al. A...
| Keywords: | GW9578, GW-9578 |
| Application: | PPARalpha agonist |
| CAS | 247923-29-1 |
| MW: | 492.62 D |
From 74.00€
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MD001
Item number: TGM-T35800-10mg
Description: MD001 is a dual agonist of peroxisome proliferator-activated receptor alpha (PPARalpha) and PPARgamma.1 It binds to PPARalpha and PPARgamma (Kds = 9.55 and 0.14 µM, respectively) but does not bind to PPARbeta/delta at concentrations up to 500 µM. It increases transcriptional activity of PPARalpha and...
| Application: | Peroxisome proliferator-activated receptor (PPARalpha / PPARgamma) agonist |
| CAS | 2254605-76-8 |
| MW: | 398.41 D |
1,059.00€
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