212 products were found matching "K07203"!
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Rapamycin
Item number: Cay13346-1
Rapamycin is an allosteric inhibitor of the mammalian target of rapamycin (mTOR) complex 1 (mTORC1) originally isolated from S. hygroscopicus. It interacts with FKBP prolyl isomerase 1A (FKBP12) to form a complex that binds to and inhibits the kinase activity of mTORC1. Rapamycin inhibits growth of Rh1 and Rh30...
| Keywords: | AY 22989, NSC 226080, Wy 090217,... |
| Application: | mTORC1 blocking |
| CAS | 53123-88-9 |
| MW: | 914.2 D |
From 50.00€
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Torin 1
Item number: Cay10997-10
Torin 1 is a potent and selective inhibitor of mTOR (IC50 = 2 and 10 nM for mTORC1 and mTORC2, respectively). It shows over 100-fold selectivity for mTOR over PI3Kalpha and other PI3K-like kinases, including ATM, DNA-PK, and hVps34, as well as 450 other protein kinases. Torin 1, is efficacious at a dose of 20 mg/kg...
| Keywords: | 1-[4-[4-(1-oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one |
| Application: | mTor inhibitor |
| CAS | 1222998-36-8 |
| MW: | 607.6 D |
From 196.00€
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PQR620
Item number: Cay26656-1
PQR620 is an inhibitor of mTOR (Ki = 10.8 nM). It is selective for mTOR over PI3K p110alpha (Ki = 4.2 µM) and a panel of 456 other kinases at 10 µM. PQR620 has antiproliferative activity against a panel of 66 cancer cell lines (mean IC50 = 919 nM). It induces cell cycle arrest at the G1 phase in A2058 melanoma and...
| Keywords: | 5-[4,6-bis(3-oxa-8-azabicyclo[3.2.1]oct-8-yl)-1,3,5-triazin-2-yl]-4-(difluoromethyl)-2-pyridinamine |
| Application: | mTOR inhibitor |
| CAS | 1927857-56-4 |
| MW: | 445.5 D |
From 48.00€
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Everolimus
Item number: TGM-T1784-10mg
Description: Everolimus (SDZ-RAD) is a potent mTOR inhibitor that binds to FKBP-12. It is used alone or in combination with calcineurin inhibitors. Target: Others, Autophagy, mTOR, Apoptosis. Smiles:...
| Keywords: | SDZ-RAD, RAD001 |
| Application: | Targets serine/threonine-protein kinase mTOR [EC:2.7.11.1] (MTOR, FRAP, TOR) |
| CAS | 159351-69-6 |
| MW: | 958.22 D |
From 37.00€
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mTOR inhibitor-3
Item number: TGM-T12123-100mg
Description: mTOR inhibitor-3 is a selective mTOR inhibitor (Ki= 1.5 nM). mTOR inhibitor-3 inhibits mTORC1 and mTORC2 in cellular and in vivo experiments. Target: mTOR. Smiles: CCNC(=O)Nc1ccc(cc1)-c1nc2CN(CCc2c(n1)N1CCOC[C@@H]1C)c1ncccn1. References: Pei Z, et al. Discovery and Biological Profiling of Potent and...
| Application: | mTOR inhibitor |
| CAS | 1207358-59-5 |
| MW: | 474.56 D |
From 54.00€
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mTOR inhibitor-2
Item number: TGM-T12124-100mg
Description: mTOR inhibitor-2 is an inhibitor of selective and oral mTOR (IC50 of 7 nM). Target: mTOR. Smiles: O=C1N(C2=C3C(=NC=C2N=C1)C=CC(=C3)C=4C=CC(N)=NC4)C5CCN(CC#N)CC5. References: Guo Q, et al. Highly Selective, Potent, and Oral mTOR Inhibitor for Treatment of Cancer as Autophagy Inducer. J Med Chem. 2018 Feb...
| Application: | mTOR inhibitor |
| CAS | 2219323-96-1 |
| MW: | 411.46 D |
From 1,638.00€
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Rapamycin-d3
Item number: TGM-T12691-100mg
Description: Rapamycin-d3 is the deuterium labeled Rapamycin. Rapamycin is a potent and specific inhibitor of mTOR(IC50 of 0.1 nM in HEK293 cells). Smiles:...
| Keywords: | Sirolimus-d3, AY-22989-d3 |
| Application: | Immunosuppressant, LC/MS internal standard |
| CAS | 392711-19-2 |
| MW: | 917.19 D |
From 7,078.00€
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PQR530
Item number: TGM-T16567-100mg
Description: PQR530 is a highly potent dual pan-PI3K/mTORC1/2 inhibitor. PQR530 inhibited protein kinase B (PKB, pSer473) and ribosomal protein S6 (pS6, pSer235/236) phosphorylation with IC50 values of 0.07 µM. It also showing antitumor activity. Target: mTOR, PI3K. Smiles:...
| Keywords: | PQR-530 |
| Application: | PI3Kalpha / mTOR dual inhibitor |
| CAS | 1927857-61-1 |
| MW: | 407.42 D |
From 48.00€
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Temsirolimus
Item number: TGM-T2145-2mg
Description: Temsirolimus (CCI-779) is a specific mTOR inhibitor ( IC50: 1.76 µM), used in the treatment of advanced renal cell cancer. Target: Apoptosis, mTOR, Autophagy. Smiles:...
| Keywords: | NSC 683864, CCI-779 |
| Application: | Targets serine/threonine-protein kinase mTOR [EC:2.7.11.1] (MTOR, FRAP, TOR) |
| CAS | 162635-04-3 |
| MW: | 1030.29 D |
From 38.00€
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CZ415
Item number: TGM-T3514-100mg
Description: CZ415 is a potent and highly selective mTOR inhibitor. This compound has a molecular weight of 432.51 g/mol and demonstrates an inhibition constant (IC50) of 5.8 nM against mTOR. Additionally, CZ415 has shown to be efficacious in preclinical models of cancer, indicating its potential therapeutic...
| Application: | mTOR inhibitor |
| CAS | 1429639-50-8 |
| MW: | 459.56 D |
From 58.00€
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Palomid 529
Item number: TGM-T2706-100mg
Description: Palomid 529 (SG 00529) has been used in trials studying the treatment of Age-Related Macular Degeneration. Target: mTOR, Apoptosis. Smiles: COc1ccc(COc2cc3oc(=O)c4cc(ccc4c3cc2OC)C(C)O)cc1. References: Xue Q, et al. Cancer Res, 2008, 68(22), 9551-9557.
| Keywords: | SG 00529, P529 |
| Application: | mTORC1/2 inhibitor |
| CAS | 914913-88-5 |
| MW: | 406.43 D |
From 40.00€
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Compound 28
Item number: TGM-T36307-1mg
Description: Compound 28 (mTOR inhibitor WYE-28) is a selective inhibitor of mTOR (IC50=0.08 nM). Also inhibits PI3Kalpha (IC50 6 nM). Target: Others. Smiles: COC(=O)N1CCC(CC1)n1ncc2c(nc(nc12)-c1ccc(NC(=O)Nc2ccc(CO)cc2)cc1)N1CCOCC1
| Application: | mTOR Inhibitor |
| CAS | 1062172-60-4 |
| MW: | 586.653 D |
From 108.00€
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