92 products were found matching "K06642"!
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Anti-PRKDC
Item number: ABS-KC-6291.100
Protein function: Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805). Must be bound to DNA to express its catalytic...
| Keywords: | Anti-DNA-dependent protein kinase catalytic subunit, Anti-DNA-PK catalytic subunit, Anti-DNA-PKcs, Anti-DNPK1, Anti-p460,... |
| Host: | Mouse |
| Species reactivity: | human |
From 232.00€
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NEW
Anti-PRKDC
Item number: ABS-KC-6292.100
Protein function: Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805). Must be bound to DNA to express its catalytic...
| Keywords: | Anti-DNA-dependent protein kinase catalytic subunit, Anti-DNA-PK catalytic subunit, Anti-DNA-PKcs, Anti-DNPK1, Anti-p460,... |
| Host: | Mouse |
| Species reactivity: | human |
From 232.00€
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VX-984
Item number: Cay42072-1
VX-984 is an inhibitor of DNA protein kinase (DNA-PK). It inhibits radiation-induced increases in phosphorylated DNA-PK levels in U251 and NSC11 glioblastoma cells when used at concentrations of 250 or 500 nM. VX-984 (1 µM) induces mutagenic NHEJ and homologous recombination DNA repair pathways in a reporter assay...
| Keywords: | M-9831, N-methyl-8-[(1S)-1-methyl-2-[(2'-methyl[4,5'-bipyrimidin]-6-yl-4',6'-d2)amino]ethyl]-4-quinolinecarboxamide |
| Application: | DNA-PK inhibitor |
| CAS | 1476074-39-1 |
| MW: | 415.5 D |
From 108.00€
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CC-115
Item number: TGM-T3541-100mg
Description: CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM). Target: DNA-PK, PI3K, mTOR. Smiles: CCN1C(=O)CNc2ncc(nc12)-c1ccc(nc1C)-c1ncn[nH]1. References: Thijssen R, et al. Blood. 2016, 128(4):574-83.
| Keywords: | CC 115 |
| Application: | DNA-PK / mTOR inhibitor |
| CAS | 1228013-15-7 |
| MW: | 336.35 D |
From 40.00€
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KU-57788
Item number: TGM-T6276-100mg
Description: NU7441 (KU-57788 (NU7441)) is a highly effective and specific DNA-PK inhibitor (IC50: 14 nM). Target: CRISPR/Cas9, DNA-PK. Smiles: O=c1cc(oc2c(cccc12)-c1cccc2c3ccccc3sc12)N1CCOCC1. References: Sunada S, et al. Nontoxic concentration of DNA-PK inhibitor NU7441 radio-sensitizes lung tumor cells with...
| Keywords: | NU7441 |
| Application: | DNA-PK inhibitor |
| CAS | 503468-95-9 |
| MW: | 413.49 D |
From 34.00€
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AZD-7648
Item number: TGM-T7122-100mg
Description: AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity. Target: DNA-PK. Smiles: Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n(C3CCOCC3)c2n1. References: Maurice Raymond Verschoyle Finlay, et al. Amino-triazolopyridine compounds and their...
| Application: | DNA-PK inhibitor |
| CAS | 2230820-11-6 |
| MW: | 380.4 D |
From 34.00€
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DNA-PKcs Protein, Dictyostelium discoideum, Recombinant...
Item number: TGM-TMPH-00476-100ug
Description: DNA-PKcs Protein, Dictyostelium discoideum, Recombinant (His & Myc) is expressed in E. coli.
| Keywords: | DNA-PKcs, DNA-dependent protein kinase catalytic subunit, dnapkcs, DNA-PK catalytic subunit |
| MW: | 46.1 kD |
From 359.00€
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KU-0060648
Item number: TGM-T6557-100mg
Description: KU-0060648 is a dual inhibitor of DNA-PK and PI3Kalpha, PI3Kbeta, PI3Kdelta with IC50 values of 8.6 nM, 4 nM, 0.5 nM, and 0.1 nM respectively, and demonstrates less inhibition of PI3Kgamma with an IC50 of 0.59 µM. Target: mTOR, PI3K, DNA-PK. Smiles:...
| Keywords: | KU0060648 |
| Application: | Dual PI3K & DNA-PK inhibitor |
| CAS | 881375-00-4 |
| MW: | 582.71 D |
From 55.00€
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LTURM34
Item number: TGM-T15789-100mg
Description: LTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM. LTURM34 displays effective antiproliferative activity in a wide range of tumor cell lines. LTURM34 shows 170-fold selectivity for DNA-PK over PI3K . Target: PI4K, PI3K, DNA-PK. Smiles: O=c1nc(oc2c(cccc12)-c1cccc2c3ccccc3sc12)N1CCOCC1. References:...
| Application: | DNA-PK inhibitor |
| CAS | 1879887-96-3 |
| MW: | 414.48 D |
From 40.00€
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NU 7026
Item number: Cay13308-5
DNA-dependent protein kinase (DNA-PK) binds to strand breaks produced during normal cellular processes or in response to genotoxic stresses, such as ionizing radiation, targeting substrates that facilitate DNA repair. NU 7026 is a cell-permeable, potent, specific, and ATP-competitive inhibitor of DNA-PK (IC50 = 230...
| Keywords: | DNA-PK Inhibitor II, LY293646, 2-(4-morpholinyl)-4H-naphtho[1,2-b]pyran-4-one |
| Application: | DNA-PK inhibitor |
| CAS | 154447-35-5 |
| MW: | 281.3 D |
From 111.00€
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DNA-dependent protein kinase catalytic subunit (Prkdc),...
Item number: CSB-EP018714MO.1
Organism: Mus musculus (Mouse). Source: E.coli. Expression Region: 3747-4015aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: EYPFLVKGGE DLRQDQRIEQ IFEVMNAILS QDAACSQRNM QLRTYRVVPM TSRLGLIEWI ENTMTLKDLL LSNMSQEEKV ANNSDPKAPI RDYKDWLMKV SGKSDAGAYV LMYSRANRTE TVVAFRRRES...
| Keywords: | p460, Xrcc7, Prkdc, DNA-PKcs, DNA-PK catalytic subunit, DNA-dependent protein kinase catalytic subunit, Recombinant Mouse... |
| Application: | Activity not tested |
| Expressed in: | E.coli |
| Origin: | mouse |
| MW: | 34.6 kD |
From 292.00€
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DNA-dependent protein kinase catalytic subunit (dnapkcs),...
Item number: CSB-EP703860DKK.1
Organism: Dictyostelium discoideum (Slime mold). Source: E.coli. Expression Region: 3910-4250aa. Protein Length: Partial. Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged. Target Protein Sequence: ELDYPFLIKG GEDLRLDQRI QQLFGIMNEI LKRDTACNKR SLNVTTYQVV PMTSKVGIIE WLNDTKPLRE ILEEQLAHQL KTPRSNVSIS...
| Keywords: | dnapkcs, DNA-PKcs, EC=2.7.11.1, DDB_G0281167, DNA-PK catalytic subunit, DNA-dependent protein kinase catalytic subunit,... |
| Application: | Activity not tested |
| Expressed in: | E.coli |
| Origin: | Dictyostelium discoideum (Slime mold) |
| MW: | 46.1 kD |
From 364.00€
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